Protein Alignment Meltrin and adam19

DIOPT Version :10

• Sequence 1: NP_001027575.1
• Gene: Meltrin / 3772109
• FlyBaseID: FBgn0265140
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: NP_001035105.1
• Gene: adam19 / 677730
• XenbaseID: XB-GENE-993485
• Length: 911
• Species: Xenopus tropicalis
• Alignment Length: 965
• Identity: 295/965 - (30%)
• Similarity: 441/965 - (45%)
• Gaps: 198/965 - (20%)

  Fly    76 GLHTPQISLSYTHEGKRVVVDLQRNDLLL-PNSHFLRYQ-NASRGATPGHVVTTFTKTEVDLCHY 138
            |.:.....|....||:.:::.|.||:..: ||.....|. |.:|      ||.|...||  .|:|
 Frog    61 GKYPEHAELLVKAEGQDLILSLHRNEQFIHPNYRETHYSLNYTR------VVRTPNMTE--HCYY 117

  Fly   139 QGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTNATCGY 203
            .|.::.:..|.|.:|.|.|....|.:....:|.:.| :.|    :|..:::.:|:....:..|
 Frog   118 HGIVQEQDNSSVVISICSGIRGMITLSNNLSYIVEP-LPG----EDGRHVIYKAEHLGLSRIC-- 175

  Fly   204 DNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDSSQLIRGPYNANKYSS 268
                ..||..:|:.         :|:|...|.|..     .|.||:..:..:.
 Frog   176 ----HGHSIHFEEK---------LPTLTSNLSGHH-----SRVRRENVEGERC------------ 210

  Fly   269 YVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNESNEIEFSSDG 333
             |||.:|.|...::....:.::..:....:.|.|:..|..|||.:||||:.:|...::...|.:.
 Frog   211 -VELYLVADYAEFQKHDSDLEETQRKMLEVMNYIDKFYRALNIRIALVGLEVWTAGDKCNVSENP 274

  Fly   334 DLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPNPAMV 398
            ..|||.||::| .||:...|:|||||:|..:|.|..:|.|....:|:...||||:|.||.|...|
 Frog   275 YSTLRAFLSWR-RKLLQHTPHDNAQLITGRSFYGTTIGLAPLQAMCSVYQSGGVNMDHSDNAIGV 338

  Fly   399 ATTMAHEMGHNFGMEHDTSDCHC----RDEKCVMAASSTSFIPVNWSSCSIDQLTIAFSRGMNYC 459
            |.|||||:||||||.||.:.| |    .:..|:||||:....|..:::|:..:|...|..|...|
 Frog   339 AATMAHELGHNFGMSHDAAGC-CTAKPEEGGCIMAASTGHPFPKVFNACNKQELDRFFRSGGGMC 402

  Fly   460 LRNKPE--RLFESPTCGNGFVEPGEQCDCGLPEHCENACCNAQTCMLHSKNATCATGECCDLTTC 522
            |.|.|:  .||..|.|||||:|.|||||||.||.|.|.||||.||.|.: .|.||.|.||  ..|
 Frog   403 LSNLPDTKTLFGGPRCGNGFLEEGEQCDCGDPEQCNNPCCNATTCTLMA-GADCAHGACC--LRC 464

  Fly   523 RPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWG 587
            :.:..|..||:....|||||:|||:|..||.:.|:.|...|.|.||:|::|.|.:|..||:.|||
 Frog   465 KLRPPGFPCRKPSRPCDLPEFCTGQSAVCPPNSFQLDGTLCQGEQAFCYNGRCLTHQQQCQQLWG 529

  Fly   588 PTGDNS-EHCYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERLEFGMESAAVL 650
            .....: :.|:.. |..|.:.||||.: ::.|:..||.:.|.||.:.|:   .:....|||.||.
 Frog   530 ARSRVAPDLCFELINVAGDQYGNCGRD-MSGTYRSCEGRDVMCGKIQCL---SQASKPMESNAVA 590

  Fly   651 SHSYISHDRKIVACRTALV-----DLGLQTTDPGLTPNGAKCGVDKMCVDQRC-----LPVDAVR 705
            ..:.|:.:.|.|.||...:     ||    .||||...|.|||::::|.|.:|     |.||
 Frog   591 IDTTITIEGKRVQCRGTHIYKEEDDL----MDPGLVLTGTKCGLNQICFDGQCRNTSFLQVD--- 648

  Fly   706 QKGMGKPCPEDCNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSGPATDPNGSVGFKRFLYVL 770
                  .|.:.|:|||:||:..:|||..|:....|::.|:|||.||||..: :||      |.::
 Frog   649 ------ECAKKCHGNGMCNNNRNCHCFAGWRPPFCNQTGNGGSIDSGPVPE-DGS------LALV 700

  Fly   771 FFFVLPV---------VALFWFLYHCYKNGMLTRGKLADNILKSSGGSKPITTRTNQNGTGPPPS 826
            .:..:|:         :|:|::::.       .||:.|..      .|.|.|...:::.:  |..
 Frog   701 LWICIPLALLAGMALSLAMFFYVFR-------IRGRQAKT------ESCPATCPLHKSDS--PTK 750

  Fly   827 NGL---------LKSTPSSTDDMDSALLKSPSDSTPS-------AGLFGKFDGFTLRPLNDASSP 875
            :|:         :...|.|...:...|....|.|..|       .|...|:           ||.
 Frog   751 HGVGSTSKQRPQVPMQPKSPPVLYPTLRVEKSQSAASQHHQEQPEGGAAKY-----------SSA 804

  Fly   876 ASNYNGPN-----------VAFVQP--------TVQQDGPQRMAPPPPVVKPGTAPIHPPSPKPE 921
            .|:::..:           |:::|.        .::...|.|.|||||.:.|     .||:|.|.
 Frog   805 ISHHSNQDLKGGAGKILHGVSYLQQGGAIKTGYAMRTPPPNRPAPPPPALAP-----TPPAPVPP 864

  Fly   922 ATWVRPAPALPPPNPGSTARPIISPPKLDSSTLTMVPLKDSTEDLSPSRSAPPVP 976
            .    ||.|.|||.|....||            ..:||            .||||
 Frog   865 P----PASAPPPPAPKRLERP------------RRLPL------------PPPVP 891

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	53..174	CDD:460254	27/99 (27%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	74/196 (38%)
		Disintegrin	479..554	CDD:459709	40/74 (54%)
		ACR	558..701	CDD:214743	52/154 (34%)
		PHA03247	<823..1261	CDD:223021	42/189 (22%)
		PHA03247	<1220..1392	CDD:223021
adam19	NP_001035105.1	Pep_M12B_propep	43..164	CDD:460254	30/115 (26%)
		Reprolysin	211..407	CDD:426256	75/197 (38%)
		DISIN	424..498	CDD:214490	40/76 (53%)
		ACR	500..642	CDD:214743	51/149 (34%)