DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and adam19

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001035105.1	Gene:	adam19 / 677730	XenbaseID:	XB-GENE-993485	Length:	911	Species:	Xenopus tropicalis

Alignment Length:	965	Identity:	295/965 - (30%)
Similarity:	441/965 - (45%)	Gaps:	198/965 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 GLHTPQISLSYTHEGKRVVVDLQRNDLLL-PNSHFLRYQ-NASRGATPGHVVTTFTKTEVDLCHY 138
            |.:.....|....||:.:::.|.||:..: ||.....|. |.:|      ||.|...||  .|:|
Frog    61 GKYPEHAELLVKAEGQDLILSLHRNEQFIHPNYRETHYSLNYTR------VVRTPNMTE--HCYY 117

  Fly   139 QGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTNATCGY 203
            .|.::.:..|.|.:|.|.|....|.:....:|.:.| :.|    :|..:::.:|:....:..|
Frog   118 HGIVQEQDNSSVVISICSGIRGMITLSNNLSYIVEP-LPG----EDGRHVIYKAEHLGLSRIC-- 175

  Fly   204 DNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDSSQLIRGPYNANKYSS 268
                ..||..:|:.         :|:|...|.|..     .|.||:..:..:.
Frog   176 ----HGHSIHFEEK---------LPTLTSNLSGHH-----SRVRRENVEGERC------------ 210

  Fly   269 YVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNESNEIEFSSDG 333
             |||.:|.|...::....:.::..:....:.|.|:..|..|||.:||||:.:|...::...|.:.
Frog   211 -VELYLVADYAEFQKHDSDLEETQRKMLEVMNYIDKFYRALNIRIALVGLEVWTAGDKCNVSENP 274

  Fly   334 DLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPNPAMV 398
            ..|||.||::| .||:...|:|||||:|..:|.|..:|.|....:|:...||||:|.||.|...|
Frog   275 YSTLRAFLSWR-RKLLQHTPHDNAQLITGRSFYGTTIGLAPLQAMCSVYQSGGVNMDHSDNAIGV 338

  Fly   399 ATTMAHEMGHNFGMEHDTSDCHC----RDEKCVMAASSTSFIPVNWSSCSIDQLTIAFSRGMNYC 459
            |.|||||:||||||.||.:.| |    .:..|:||||:....|..:::|:..:|...|..|...|
Frog   339 AATMAHELGHNFGMSHDAAGC-CTAKPEEGGCIMAASTGHPFPKVFNACNKQELDRFFRSGGGMC 402

  Fly   460 LRNKPE--RLFESPTCGNGFVEPGEQCDCGLPEHCENACCNAQTCMLHSKNATCATGECCDLTTC 522
            |.|.|:  .||..|.|||||:|.|||||||.||.|.|.||||.||.|.: .|.||.|.||  ..|
Frog   403 LSNLPDTKTLFGGPRCGNGFLEEGEQCDCGDPEQCNNPCCNATTCTLMA-GADCAHGACC--LRC 464

  Fly   523 RPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWG 587
            :.:..|..||:....|||||:|||:|..||.:.|:.|...|.|.||:|::|.|.:|..||:.|||
Frog   465 KLRPPGFPCRKPSRPCDLPEFCTGQSAVCPPNSFQLDGTLCQGEQAFCYNGRCLTHQQQCQQLWG 529

  Fly   588 PTGDNS-EHCYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERLEFGMESAAVL 650
            .....: :.|:.. |..|.:.||||.: ::.|:..||.:.|.||.:.|:   .:....|||.||.
Frog   530 ARSRVAPDLCFELINVAGDQYGNCGRD-MSGTYRSCEGRDVMCGKIQCL---SQASKPMESNAVA 590

  Fly   651 SHSYISHDRKIVACRTALV-----DLGLQTTDPGLTPNGAKCGVDKMCVDQRC-----LPVDAVR 705
            ..:.|:.:.|.|.||...:     ||    .||||...|.|||::::|.|.:|     |.||
Frog   591 IDTTITIEGKRVQCRGTHIYKEEDDL----MDPGLVLTGTKCGLNQICFDGQCRNTSFLQVD--- 648

  Fly   706 QKGMGKPCPEDCNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSGPATDPNGSVGFKRFLYVL 770
                  .|.:.|:|||:||:..:|||..|:....|::.|:|||.||||..: :||      |.::
Frog   649 ------ECAKKCHGNGMCNNNRNCHCFAGWRPPFCNQTGNGGSIDSGPVPE-DGS------LALV 700

  Fly   771 FFFVLPV---------VALFWFLYHCYKNGMLTRGKLADNILKSSGGSKPITTRTNQNGTGPPPS 826
            .:..:|:         :|:|::::.       .||:.|..      .|.|.|...:::.:  |..
Frog   701 LWICIPLALLAGMALSLAMFFYVFR-------IRGRQAKT------ESCPATCPLHKSDS--PTK 750

  Fly   827 NGL---------LKSTPSSTDDMDSALLKSPSDSTPS-------AGLFGKFDGFTLRPLNDASSP 875
            :|:         :...|.|...:...|....|.|..|       .|...|:           ||.
Frog   751 HGVGSTSKQRPQVPMQPKSPPVLYPTLRVEKSQSAASQHHQEQPEGGAAKY-----------SSA 804

  Fly   876 ASNYNGPN-----------VAFVQP--------TVQQDGPQRMAPPPPVVKPGTAPIHPPSPKPE 921
            .|:::..:           |:::|.        .::...|.|.|||||.:.|     .||:|.|.
Frog   805 ISHHSNQDLKGGAGKILHGVSYLQQGGAIKTGYAMRTPPPNRPAPPPPALAP-----TPPAPVPP 864

  Fly   922 ATWVRPAPALPPPNPGSTARPIISPPKLDSSTLTMVPLKDSTEDLSPSRSAPPVP 976
            .    ||.|.|||.|....||            ..:||            .||||
Frog   865 P----PASAPPPPAPKRLERP------------RRLPL------------PPPVP 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	27/99 (27%)
		Reprolysin	269..464	CDD:279729	75/198 (38%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	74/196 (38%)
		Disintegrin	479..555	CDD:278623	40/75 (53%)
		ACR	558..701	CDD:214743	52/154 (34%)
adam19	NP_001035105.1	Pep_M12B_propep	63..163	CDD:279848	29/112 (26%)
		Reprolysin	211..407	CDD:279729	75/197 (38%)
		ZnMc_adamalysin_II_like	211..405	CDD:239797	74/195 (38%)
		DISIN	424..498	CDD:214490	40/76 (53%)
		ACR	500..642	CDD:214743	51/149 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	160	1.000	Domainoid score	I3999
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74925
Inparanoid	1	1.050	424	1.000	Inparanoid score	I1736
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0000154
OrthoInspector	1	1.000	-	-		otm48765
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060