DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and Adam18

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_038950722.1	Gene:	Adam18 / 57029	RGDID:	620405	Length:	751	Species:	Rattus norvegicus

Alignment Length:	741	Identity:	201/741 - (27%)
Similarity:	322/741 - (43%)	Gaps:	125/741 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 QISLSYTHEGKRVVVDLQRNDLLLPNSHFLRY-QNASRGATPGHVVTTFTKTEVDLCHYQGHIRG 144
            ::|...|.:||...:.|:....|..|.....| :..|..:...|.:..        |||:|::..
  Rat    77 KVSYVITIDGKPYFLHLRNYSFLSRNFSVYAYNETGSLYSDSPHFLAH--------CHYRGYVGE 133

  Fly   145 KPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLK-QADMHPTNATCGYDNHRD 208
            .|:|:|.||.|.| |.|.:.....:|.|.| ::...|.:...|.:| .:.....|.:|.:...|
  Rat   134 VPDSIVTLSLCSG-LRGFLQLENTSYGIEP-LESSARFEHIVYQMKSNSSTLAANYSCIWQTSR- 195

  Fly   209 DHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDSSQLIRGPYNANKYSSYVELV 273
                                    :||.|.|       |.|..:.|||:         ...::|.
  Rat   196 ------------------------QLDKGHF-------REQDKNDSQLL---------PKSLKLH 220

  Fly   274 IVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNESNEIEFSSDGDLT-- 336
            |:|...::.....:...|.|....|..::|.::..||:.|.|..:.:|::.|:|  |:||:.:
  Rat   221 IIVGKFLFDYMGSDIMAVTQKIFQIIGLVNTMFTQLNLNVVLASLELWSDKNQI--STDGNASDI 283

  Fly   337 LRNFLNYRSTKLVLDHPNDNA---QLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPNP--- 395
            |:..|.::...|.   |..|.   .|:.:::..  .:|....|.:|...|..||...  |..
  Rat   284 LQRLLGWKRDYLT---PQSNEITHLLIYRKHLK--YIGATSPGELCNESYVAGVGTY--PEDIGL 341

  Fly   396 ---AMVATTMAHEMGHNFGMEHDTSD-CHCRDEKCVM---AASSTSFIPVNWSSCSIDQLTIAFS 453
               :||.|.:   :|.:.|:.:|..| |.|....|:|   |.||:..  ..:|:||:...|...|
  Rat   342 EGLSMVITQL---IGLHIGLTYDDVDNCSCPRAPCIMQPEALSSSGM--KTFSNCSVHDYTHYAS 401

  Fly   454 RGMNYCLRN-----KPERLFESPTCGNGFVEPGEQCDCGLPEHCE-NACCNAQTCMLHSKNATCA 512
            :....||.:     :|::    ..||||.||..|:||||....|: ..|||.:||.|.. :|.|.
  Rat   402 KLDMQCLGDLSNVLQPKQ----SVCGNGIVEGSEECDCGNETECQFKECCNHETCKLKG-SAQCG 461

  Fly   513 TGECCDLTTCRPKLAGSACREA-ENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCR 576
            :|.|| ...|....||:.||:| :.|||..|||.|.|.:|..|.|..|...|..|.|||::|.|:
  Rat   462 SGTCC-TPKCELSAAGTPCRKAVDPECDFTEYCDGSSSHCVPDTFALDGHLCRLGSAYCYNGRCQ 525

  Fly   577 SHSNQCRTLWGPTGDNSEH-CYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNER 639
            :.::||.:|:|.....:.: |:.| |::...|.||  :..|...|.|.::.|.||.|.|...|:.
  Rat   526 ALNDQCVSLFGKGSQGASYACFEKVNSQRENLANC--DSKNSYSLPCGQKDVLCGKLACFRPNKN 588

  Fly   640 LEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQT--TDPGLTPNGAKCGVDKMCVDQRCLPVD 702
            .:...:|   :.:||:...    .|.:....|.:::  .|.....:|..||....|::..|..|:
  Rat   589 YKSSTQS---VLYSYVHGS----VCLSIPPGLSMRSDGKDNAYVADGTVCGPQMYCINGSCKEVN 646

  Fly   703 AVRQKGMGKPC--PEDCNGNGICNSRGHCHCDVGFGGESCS-KAGS-GGSPDSGPATDPNGSVGF 763
            ..     |..|  .:.|.||||||:.|||.|...:....|: :.|| |||.|.|.....:.::..
  Rat   647 FT-----GNDCNAAKKCKGNGICNNFGHCQCFPDYRPPDCNLQIGSPGGSIDDGNLLRTDSALAT 706

  Fly   764 KR-------FLYVLFFFVLP-VVALF 781
            ||       ::.:.||..|| ::.||
  Rat   707 KRLSQHADSWVILGFFIFLPFIMTLF 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	25/93 (27%)
		Reprolysin	269..464	CDD:279729	51/214 (24%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	51/207 (25%)
		Disintegrin	479..555	CDD:278623	33/77 (43%)
		ACR	558..701	CDD:214743	38/146 (26%)
Adam18	XP_038950722.1	Pep_M12B_propep	59..174	CDD:396235	27/106 (25%)
		ZnMc_adamalysin_II_like	215..408	CDD:239797	49/206 (24%)
		Disintegrin	428..503	CDD:395147	33/76 (43%)
		ACR	507..645	CDD:214743	38/146 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920