DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Meltrin and Adam17

DIOPT Version :9

Sequence 1:NP_001027575.1 Gene:Meltrin / 3772109 FlyBaseID:FBgn0265140 Length:1407 Species:Drosophila melanogaster
Sequence 2:NP_064702.2 Gene:Adam17 / 57027 RGDID:620404 Length:827 Species:Rattus norvegicus


Alignment Length:1135 Identity:233/1135 - (20%)
Similarity:354/1135 - (31%) Gaps:408/1135 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 LLLNTCLQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRTKRSLLTTLDATDG 76
            ||..|.|...:|.|      ...|...|.:||.||:..                |||:..|....
  Rat     5 LLFLTTLVPFVLAP------RPPEEPGSGSHPRLEKLD----------------SLLSDYDILSL 47

  Fly    77 LHTPQISLSYTHEGKRVVVDLQRNDLLLPNS----HFLRYQNAS--RGATPGHVVTTFTKTEVDL 135
            .:..|.|:.     ||.:......:.||..|    ||..|..:|  |.:....||....|.|.:.
  Rat    48 SNIQQHSIR-----KRDLQSATHLETLLTFSALKRHFKLYLTSSTERFSQNLRVVVVDGKEESEY 107

  Fly   136 C-----HYQGHIRGKPESVVALSTCDGALDGIVI----DGRQTYFIHPHIDGRGRLQDDHYLL-K 190
            .     .:.||:.|:|:|.|.....|   |.:.:    ||.: |.|.|........:|...|: |
  Rat   108 SVKWQDFFSGHVVGEPDSRVLAHIGD---DDVTVRINTDGAE-YNIEPLWRFVNDTKDKRMLVYK 168

  Fly   191 QADMH-----PTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQA 250
            ..|:.     .:...|||.|           ||.:..|..|:..   |....||.|   |.:|:|
  Rat   169 SEDIKDFSRLQSPKVCGYLN-----------ADSEELLPKGLID---REPSEEFVR---RVKRRA 216

  Fly   251 DDSSQLIRGPYNANKYSSYVELVIVVDNKVYK----------------------NFQENTKKVHQ 293
            :           .|...:..:|::|.|::.||                      :...||...:.
  Rat   217 E-----------PNPLKNTCKLLVVADHRFYKYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA 270

  Fly   294 YCKGIANIINALYVPLNIFVALVGVVIWNES----NEIEFSSDGDLTLRNF---LNYRSTKLVLD 351
            ..||....|..:.:..:......|...:|.:    ||.:.:.|..:.|..|   :...::|:.|.
  Rat   271 GFKGYGVQIEQIRILKSPQEVKPGERHFNMAKSFPNEEKDAWDVKMLLEQFSLDIAEEASKVCLA 335

  Fly   352 HPNDNAQLLTKENFAGGVVGKAL--------KGPIC--TYEYSGGVSMQHSPNPAMVAT------ 400
            |      |.|.::|..|.:|.|.        .|.:|  .| |:.||......|..:.:|      
  Rat   336 H------LFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAY-YNPGVKKNIYLNSGLTSTKNYGKT 393

  Fly   401 --------TMAHEMGHNFGMEHD---TSDCHCRDE---KCVMAASSTSFIPVN---WSSCSIDQL 448
                    ...||:|||||.|||   .::|...::   |.||...:.|....|   :|:||...:
  Rat   394 ILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSI 458

  Fly   449 TIAFSRGMNYCLRNKPERLFESPTCGNGFVEPGEQCDCGLPEHCENACCNAQTCMLHSKNATCAT 513
            ..........|.:.:..::     |||..|:.||:||.|:.....:.|||:...:......:...
  Rat   459 YKTIESKAQECFQERSNKV-----CGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKPGVQCSDRN 518

  Fly   514 GECCDLTTCRPKLAGSACREAEN-ECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRS 577
            ..||  ..|:.:.|...|:||.| .|....||||.|..||                         
  Rat   519 SPCC--KNCQFETAQKKCQEAINATCKGVSYCTGNSSECP------------------------- 556

  Fly   578 HSNQCRTLWGPTGDNSEHCYNKNTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERLEF 642
                      |.||..:     :|....||.|...:                   ||        
  Rat   557 ----------PPGDAED-----DTVCLDLGKCKAGK-------------------CI-------- 579

  Fly   643 GMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPGLTPNGAKCGVDKMC---VDQRCLPVDAV 704
                      .:...::::.:|..|..|              ..|   |:|   :...|:|....
  Rat   580 ----------PFCKREQELESCACADTD--------------NSC---KVCCRNLSGPCVPYVDA 617

  Fly   705 RQKGM----GKPCPEDCNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSGPATDPNGSVGFKR 765
            .||.:    ||||..     |.|:..|.|.                                 ||
  Rat   618 EQKNLFLRKGKPCTV-----GFCDMNGKCE---------------------------------KR 644

  Fly   766 FLYVLFFFVLPVVALFW-FLYHCYKNGMLTRGK-LADNILKSSGGSKPITTRTNQNGTGPPPSNG 828
                    |..|:..|| |:.....|   |.|| |||||:    ||..:.:              
  Rat   645 --------VQDVIERFWDFIDQLSIN---TFGKFLADNIV----GSVLVFS-------------- 680

  Fly   829 LLKSTPSS--TDDMDSALLKSPSDSTPSAGLFGKFDGFTLRPLNDASSPASNYNGPNVAFVQPTV 891
            |:...|.|  ...:|..|.|    ...|..||...:...|..::.||                  
  Rat   681 LIFWIPFSILVHCVDKKLDK----QYESLSLFHHSNIEMLSSMDSAS------------------ 723

  Fly   892 QQDGPQRMAPPPPVVKPGTAPIHPPSPKPEATWVRPAPALPPPNPGSTARPIISPPKLDSSTLTM 956
                       ..::||..||..|...:.    ::||..:|         |:.:.||||...:..
  Rat   724 -----------VRIIKPFPAPQTPGRLQA----LQPAAMMP---------PVSAAPKLDHQRMDT 764

  Fly   957 VPLKDSTEDLSPSRSAPPVPLHADPKLNVKRDGTIRRFASFLKKEEKPPLKEKTYIDRERLRTLE 1021
            :....||:.            |.|.      ||.           ||.|....:    ...::.|
  Rat   765 IQEDPSTDS------------HVDD------DGF-----------EKDPFPNSS----AAAKSFE 796

  Fly  1022 ISAPMPVPAAPQAESSNSDSETTPREEETQ 1051
            .....||..:.:|.|.....::....:||:
  Rat   797 DLTDHPVTRSEKAASFKLQRQSRVDSKETE 826

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MeltrinNP_001027575.1 Pep_M12B_propep 64..174 CDD:279848 32/124 (26%)
Reprolysin 269..464 CDD:279729 54/256 (21%)
ZnMc_adamalysin_II_like 269..462 CDD:239797 54/254 (21%)
Disintegrin 479..555 CDD:278623 24/76 (32%)
ACR 558..701 CDD:214743 16/145 (11%)
Adam17NP_064702.2 Pep_M12B_propep 52..167 CDD:396235 31/123 (25%)
Cysteine switch. /evidence=ECO:0000250 182..189 4/17 (24%)
ZnMc_TACE_like 223..477 CDD:239798 54/260 (21%)
DISIN 484..559 CDD:214490 25/111 (23%)
ADAM17_MPD 581..642 CDD:406977 17/82 (21%)
Crambin-like 603..671 26/116 (22%)
SH3-binding. /evidence=ECO:0000255 731..738 3/6 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 766..827 16/94 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D162519at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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