DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meltrin and Adam3a

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_064698.1	Gene:	Adam3a / 57021	RGDID:	621469	Length:	740	Species:	Rattus norvegicus

Alignment Length:	826	Identity:	220/826 - (26%)
Similarity:	343/826 - (41%)	Gaps:	183/826 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLPLLLLNTCLQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRTKRSLLTTLD 72
            :|||.|:.:||.|.|                    .|.::..|     |.::....::......|
  Rat     1 MLPLFLVLSCLGQLI--------------------AVGKDIET-----PLIQITVPEKIETNIKD 40

  Fly    73 ATDGLHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTKTEVDLCH 137
            |.:.  ..|::.....|||...:.|::...|.|  ||:...:...|....:.  :..|:.   |.
  Rat    41 AKES--ETQVTYVIRIEGKAYTLQLEKQSFLHP--HFVTNLHNKLGTLQPYF--SLVKSH---CF 96

  Fly   138 YQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTNATCG 202
            ||||....|.|.|.||||.| |.|::.....||.|.| ::....|  :|.|.:
  Rat    97 YQGHAVEIPASTVTLSTCSG-LRGLLQLENVTYGIEP-LESSTTL--EHILYE------------ 145

  Fly   203 YDNHRDDHS---HDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDSSQLIRGPYNAN 264
            ..||:.|:|   .:|..:..::|      |..:.:...:.|.:.||||
  Rat   146 IQNHKIDYSPLKENYTNSQDESG------SYRILVKPLKSSNSKLRKR----------------- 187

  Fly   265 KYSSYVELVIVVDNKVYKNFQEN----TKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNESN 325
                .:.:.|::|..::.:....    |:||.|    :..:||.::..|.:.|.|..:.||:|.|
  Rat   188 ----ILTVKIIMDKGMFDHVGSEVGVATQKVVQ----MFGLINTMFSQLKMTVMLNSLEIWSEEN 244

  Fly   326 EIEFSSDGDLTLRNFLNY------RSTK------LVLDHPNDNAQLLTKENFAGGVVGKALKGPI 378
            :||.:.|.|..|:.||.:      ::||      |..|||:              .||....|..
  Rat   245 KIETNGDADEVLQRFLLWTHKEMPQTTKEITYLLLYKDHPD--------------YVGATYHGMA 295

  Fly   379 CTYEYSGGVSMQHSPNPAMV---ATTMAHEMGHNFGMEH-DTSDCHCRDEKCVM--AASSTSFIP 437
            |..:::.|:::.  |....|   |..::..:|.|.|:.: |..:|.||...|:|  :|..:..|.
  Rat   296 CNPKFTAGIALH--PKTLGVEGFAIVLSQLLGINLGLTYDDIYNCFCRGSTCIMNPSAIHSEGIK 358

  Fly   438 VNWSSCSIDQL-TIAFSRGMNYCLRNKPERLFESP----TCGNGFVEPGEQCDCGLPEHCEN-AC 496
            | :||||:|:. .:|....::..|:.:...:...|    .|||..:||.||||||..|.|.: .|
  Rat   359 V-FSSCSMDEFRQLASQPDLDCLLKTQETEVVALPQAAKVCGNYILEPPEQCDCGPAERCSHKKC 422

  Fly   497 CNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTE 561
            |.::.|.|.| :|.|.:|.|||..||:....|..||::.::||.||:|.|.||:|.||:...|.|
  Rat   423 CKSEDCTLLS-DAECGSGACCDKRTCKIAERGRLCRKSTDQCDFPEFCNGTSEFCVADIKAADLE 486

  Fly   562 PCDGGQAYCFHGTCRSHSNQCRTLWG--PTGDNSEHCYNKNTEGTRLGNC-GYNRLNKTFLRCEE 623
            ||:...||||.|.|:....||..|:|  ..|.|.......|.:..:.||| |         ||..
  Rat   487 PCNNETAYCFKGVCQDRDRQCTDLFGKYAKGPNYVCAQEVNLQNDKFGNCHG---------RCNY 542

  Fly   624 QHVNCGMLHC----IHLNERLEFGME------SAAVLSHSYISHDRKIVACRTALVDLGLQTTDP 678
            ..:.||...|    ..|.:...|.::      ...|.:|..:.:|               :|.|.
  Rat   543 SALFCGKAVCYWSFAELVKTDVFDVQYTYLGGQVCVSAHLRVRND---------------ETKDD 592

  Fly   679 GLTPNGAKCGVDKMCVDQRCLPVDAVRQKGMGKPCPED--CNGNGICNSRGHCHCDVGFGGESCS 741
            ....:|..||..::|....||.|..:|.   .:.|..|  |.|:||||::.:|.|:.||....|.
  Rat   593 TYVRDGTICGNGQVCYRGECLRVHVLRG---DRECEADDKCQGHGICNNQNNCQCEAGFAPPECD 654

  Fly   742 KAGS--GGSPDSG---------PATDPNGSVGFKRFLYVLFFFVLP 776
            ...|  |||.|.|         |.........:|:.|.:.|:..||
  Rat   655 MTPSSPGGSMDDGFWLPLDKSTPLVIKRPGTQYKKGLLISFYVFLP 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	31/109 (28%)
		Reprolysin	269..464	CDD:279729	55/217 (25%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	55/215 (26%)
		Disintegrin	479..555	CDD:278623	36/76 (47%)
		ACR	558..701	CDD:214743	39/155 (25%)
Adam3a	NP_064698.1	Pep_M12B_propep	40..141	CDD:279848	33/113 (29%)
		Reprolysin	193..382	CDD:279729	54/209 (26%)
		ZnMc_adamalysin_II_like	193..381	CDD:239797	54/208 (26%)
		Disintegrin	404..480	CDD:278623	36/76 (47%)
		ACR	483..615	CDD:214743	39/155 (25%)
		EB	601..650	CDD:279949	19/51 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920