DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meltrin and Adam2

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_064462.2	Gene:	Adam2 / 56806	RGDID:	69299	Length:	737	Species:	Rattus norvegicus

Alignment Length:	818	Identity:	232/818 - (28%)
Similarity:	365/818 - (44%)	Gaps:	136/818 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LFLLPLLLLNTCLQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRTKRSLLTT 70
            ::||.|||........:.:|       |:||.:.|.|             .||......||:
  Rat     1 MWLLLLLLSGLSRLGGLSEP-------QTEGTREKLH-------------VQVTVPEKIRSV--- 42

  Fly    71 LDATDGLHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTKTEVDL 135
              .::|..| |::.|...|||..:::|.:...|.||  |..|...|.|     ::....:...::
  Rat    43 --TSEGYET-QVTYSLKIEGKTYILNLMQKAFLPPN--FRVYSYDSTG-----IMRPLEQKFQNI 97

  Fly   136 CHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTNAT 200
            |::||:|.|.|.|:|.:|||.| |.|::..|..:|.|                      .|..::
  Rat    98 CYFQGYIEGYPNSMVIVSTCTG-LRGVLQFGNVSYGI----------------------EPLESS 139

  Fly   201 CGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQAD--DSSQLIRGPYNA 263
            .|:::    ..:..|...||                     |||...:..|  |....||.....
  Rat   140 SGFEH----VIYQVEPKKGD---------------------TLLYAEKDMDLRDPQYKIRSIKPQ 179

  Fly   264 NKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNESNEIE 328
            ...|.|:|:.|||:.:::::...:|..|.|....:..:.||::.|.|:.|.|..:..|.:.|:|.
  Rat   180 RTVSHYLEIHIVVEKQMFEHIGADTAVVTQKIFQLIGLTNAIFAPFNLTVILSSLEFWMDENKIS 244

  Fly   329 FSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSP 393
            .:.|.:..|..||.::.:.||| .|:|.|.||...: ....||...:|.:|...|:|||::
  Rat   245 TTGDANKLLYRFLKWKQSYLVL-RPHDMAFLLVYRD-TTDYVGATYQGKMCDKNYAGGVAL---- 303

  Fly   394 NPAMV-----ATTMAHEMGHNFGMEH-DTSDCHCRDEKCVMAASSTSFIPV-NWSSCSIDQLTIA 451
            :|..|     |..:...:..:.|:.: |.:.|.|....|||...:.....| ::|:||::..:..
  Rat   304 HPKAVTLESLAIILVQLLSLSMGVAYDDVNTCQCGVPICVMNPEALHSSGVRSFSNCSMEDFSKF 368

  Fly   452 FSRGMNYCLRNKP--ERLFESPTCGNGFVEPGEQCDCGLPEHCEN---ACCNAQTCMLHSKNATC 511
            .:...::||:|:|  :..::...||||.:|.||.|||| .|.|::   .|||..||.| |:.:||
  Rat   369 IASQSSHCLQNQPHLQPSYKMAVCGNGELEEGEVCDCG-QEGCDDKPPPCCNPTTCQL-SEGSTC 431

  Fly   512 ATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCR 576
            :||.||| .:|..|..|..||.|..|||:.|||.|.||.|..|.|.:|..||...:..|.:|||:
  Rat   432 STGSCCD-ASCNLKAKGELCRPANQECDVTEYCNGTSEVCEEDFFVQDGHPCAEQKWICINGTCQ 495

  Fly   577 SHSNQCRTLWGPTGD-NSEHCYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNER 639
            |.:.|||.|:|...| .::.||:: |::....|:||.....  :..|......||.|.||:.:|.
  Rat   496 SGAQQCRDLFGTDADYGTKECYSELNSKSDISGSCGITPTG--YKDCAPNDRMCGKLICIYQSED 558

  Fly   640 LEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPVDAV 704
            : ..|.||.|:   |.:...:|  |.:.....|.:.:......:|..||..|:|::|.|     |
  Rat   559 I-LKMRSAIVI---YANISGQI--CISLEYPPGHKESKKMWVRDGTVCGSGKVCLNQEC-----V 612

  Fly   705 RQKGMGKPC-PEDCNGNGICNSRGHCHCDVGFGGESCSKAGS---GGSPDSG--------PATDP 757
            ....:...| ||.||.:|:||::.||||:..:....|.....   |||.|||        ||...
  Rat   613 EDTFLNYDCTPEKCNHHGVCNNKKHCHCEPTYLPPDCKNTEDTWPGGSVDSGNQQRAESIPARSY 677

  Fly   758 NGSVGFKRFLYVLFFFVLPVVALFWFLYHCYKNGMLTR 795
            ..|....:.....||.::|...:...|.     |||.:
  Rat   678 VASAYRSKSARWPFFLIIPFYVVILVLI-----GMLVK 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	34/109 (31%)
		Reprolysin	269..464	CDD:279729	54/201 (27%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	53/199 (27%)
		Disintegrin	479..555	CDD:278623	39/78 (50%)
		ACR	558..701	CDD:214743	42/144 (29%)
Adam2	NP_064462.2	Pep_M12B_propep	32..147	CDD:396235	38/154 (25%)
		Reprolysin	184..381	CDD:396140	54/202 (27%)
		DISIN	398..475	CDD:214490	40/79 (51%)
		ACR	477..613	CDD:214743	42/148 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920