Protein Alignment Meltrin and Adam2

DIOPT Version :10

• Sequence 1: NP_001027575.1
• Gene: Meltrin / 3772109
• FlyBaseID: FBgn0265140
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: NP_064462.2
• Gene: Adam2 / 56806
• RGDID: 69299
• Length: 737
• Species: Rattus norvegicus
• Alignment Length: 818
• Identity: 232/818 - (28%)
• Similarity: 365/818 - (44%)
• Gaps: 136/818 - (16%)

  Fly     6 LFLLPLLLLNTCLQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRTKRSLLTT 70
            ::||.|||........:.:|       |:||.:.|.|             .||......||:
  Rat     1 MWLLLLLLSGLSRLGGLSEP-------QTEGTREKLH-------------VQVTVPEKIRSV--- 42

  Fly    71 LDATDGLHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTKTEVDL 135
              .::|..| |::.|...|||..:::|.:...|.||  |..|...|.|     ::....:...::
  Rat    43 --TSEGYET-QVTYSLKIEGKTYILNLMQKAFLPPN--FRVYSYDSTG-----IMRPLEQKFQNI 97

  Fly   136 CHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTNAT 200
            |::||:|.|.|.|:|.:|||.| |.|::..|..:|.|                      .|..::
  Rat    98 CYFQGYIEGYPNSMVIVSTCTG-LRGVLQFGNVSYGI----------------------EPLESS 139

  Fly   201 CGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQAD--DSSQLIRGPYNA 263
            .|:::    ..:..|...||                     |||...:..|  |....||.....
  Rat   140 SGFEH----VIYQVEPKKGD---------------------TLLYAEKDMDLRDPQYKIRSIKPQ 179

  Fly   264 NKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNESNEIE 328
            ...|.|:|:.|||:.:::::...:|..|.|....:..:.||::.|.|:.|.|..:..|.:.|:|.
  Rat   180 RTVSHYLEIHIVVEKQMFEHIGADTAVVTQKIFQLIGLTNAIFAPFNLTVILSSLEFWMDENKIS 244

  Fly   329 FSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSP 393
            .:.|.:..|..||.::.:.||| .|:|.|.||...: ....||...:|.:|...|:|||::
  Rat   245 TTGDANKLLYRFLKWKQSYLVL-RPHDMAFLLVYRD-TTDYVGATYQGKMCDKNYAGGVAL---- 303

  Fly   394 NPAMV-----ATTMAHEMGHNFGMEH-DTSDCHCRDEKCVMAASSTSFIPV-NWSSCSIDQLTIA 451
            :|..|     |..:...:..:.|:.: |.:.|.|....|||...:.....| ::|:||::..:..
  Rat   304 HPKAVTLESLAIILVQLLSLSMGVAYDDVNTCQCGVPICVMNPEALHSSGVRSFSNCSMEDFSKF 368

  Fly   452 FSRGMNYCLRNKP--ERLFESPTCGNGFVEPGEQCDCGLPEHCEN---ACCNAQTCMLHSKNATC 511
            .:...::||:|:|  :..::...||||.:|.||.|||| .|.|::   .|||..||.| |:.:||
  Rat   369 IASQSSHCLQNQPHLQPSYKMAVCGNGELEEGEVCDCG-QEGCDDKPPPCCNPTTCQL-SEGSTC 431

  Fly   512 ATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCR 576
            :||.||| .:|..|..|..||.|..|||:.|||.|.||.|..|.|.:|..||...:..|.:|||:
  Rat   432 STGSCCD-ASCNLKAKGELCRPANQECDVTEYCNGTSEVCEEDFFVQDGHPCAEQKWICINGTCQ 495

  Fly   577 SHSNQCRTLWGPTGD-NSEHCYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNER 639
            |.:.|||.|:|...| .::.||:: |::....|:||.....  :..|......||.|.||:.:|.
  Rat   496 SGAQQCRDLFGTDADYGTKECYSELNSKSDISGSCGITPTG--YKDCAPNDRMCGKLICIYQSED 558

  Fly   640 LEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPVDAV 704
            : ..|.||.|:   |.:...:|  |.:.....|.:.:......:|..||..|:|::|.|     |
  Rat   559 I-LKMRSAIVI---YANISGQI--CISLEYPPGHKESKKMWVRDGTVCGSGKVCLNQEC-----V 612

  Fly   705 RQKGMGKPC-PEDCNGNGICNSRGHCHCDVGFGGESCSKAGS---GGSPDSG--------PATDP 757
            ....:...| ||.||.:|:||::.||||:..:....|.....   |||.|||        ||...
  Rat   613 EDTFLNYDCTPEKCNHHGVCNNKKHCHCEPTYLPPDCKNTEDTWPGGSVDSGNQQRAESIPARSY 677

  Fly   758 NGSVGFKRFLYVLFFFVLPVVALFWFLYHCYKNGMLTR 795
            ..|....:.....||.::|...:...|.     |||.:
  Rat   678 VASAYRSKSARWPFFLIIPFYVVILVLI-----GMLVK 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	53..174	CDD:460254	36/120 (30%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	53/199 (27%)
		Disintegrin	479..554	CDD:459709	39/77 (51%)
		ACR	558..701	CDD:214743	42/144 (29%)
		PHA03247	<823..1261	CDD:223021
		PHA03247	<1220..1392	CDD:223021
Adam2	NP_064462.2	Pep_M12B_propep	32..147	CDD:460254	38/154 (25%)
		Reprolysin	184..381	CDD:426256	54/202 (27%)
		DISIN	398..475	CDD:214490	40/79 (51%)
		ACR	477..613	CDD:214743	42/148 (28%)