DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and Adam1a

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_064463.1	Gene:	Adam1a / 56777	RGDID:	621467	Length:	789	Species:	Rattus norvegicus

Alignment Length:	672	Identity:	200/672 - (29%)
Similarity:	282/672 - (41%)	Gaps:	138/672 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 EVDL----CHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQA 192
            ||.|    |||:|||.|.|.|.|::|.|.| |.|::|.....|.|.|.:..   ...:|.|...|
  Rat   137 EVPLLSQACHYEGHIEGVPGSFVSVSICSG-LRGVLIKEETAYGIEPLLFS---TDFEHILYTMA 197

  Fly   193 -------DMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQA 250
                   ::.||::.                  ||:                        .:||.
  Rat   198 HQPVVLCNVTPTDSL------------------GDS------------------------SQRQG 220

  Fly   251 DDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVAL 315
            ...:..:....:...::.|||:.:||:::.::.:..:.....|....|..:.|:....:|..|.|
  Rat   221 SSKTDELLALSDLWSHAKYVEMFVVVNHQRFQMWGSDVNTTVQAVVDIIALANSFTRGINTEVVL 285

  Fly   316 VGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICT 380
            ||:.||.|.:.||...|...|||||..:|..||:....:|.|.|:.... .|...|:|.....|:
  Rat   286 VGLEIWTEGDPIEVPVDLQATLRNFNLWRQEKLMGRVRHDVAHLIVGHR-PGANEGQAFLDGACS 349

  Fly   381 YEYSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSDCHCRDEK-CVM--AASSTSFIPVNWSS 442
            ..::..|...|..:..:.|..||||:|||.|:.||...|.|..:. |:|  ..|.||    .:|:
  Rat   350 GGFAAAVEAFHHEDVLLFAALMAHELGHNLGIRHDRPGCTCGPKHLCLMHETISKTS----GFSN 410

  Fly   443 CSIDQLTIAFSRGMNYCLRNKP---ERLFESPTCGNGFVEPGEQCDCGLPEHCENAC----CNAQ 500
            ||.|............||.::|   ........||||.||..|:||||      |||    |...
  Rat   411 CSSDHFLRFLHDHRGACLLDRPWHQSHKRRDAHCGNGVVEESEECDCG------NACDSHPCCEP 469

  Fly   501 TCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDG 565
            ||.| ...|.|:.|.||  ..|..|..|:.||.||:.|||||||.|.:..|||:.:.:|...||
  Rat   470 TCTL-KVGAQCSEGLCC--YKCTFKKKGTLCRPAEDVCDLPEYCNGITGECPANSYMQDGTQCD- 530

  Fly   566 GQAYCFHGTCRSHSNQCRTLWG-PTGDNSEHCY-NKNTEGTRLGNCGY-NRLNKTFLRCEEQHVN 627
            ...||..|.|::...||..::| |.....|.|| :.||:..|.||||: ...|..:..|..:.:.
  Rat   531 RIYYCSGGLCKNPDKQCARIYGYPARSAPEECYISVNTKANRFGNCGHPTSANLKYEACSNEDIF 595

  Fly   628 CGMLHC-----------IHLNERLEFG------MESAAVLSHSYISHDRKIVACRTALVDLGLQT 675
            ||.|.|           :|...::.:|      |::..|                   .|:
  Rat   596 CGKLVCTDVRYLPQVKPLHSLLQIPYGDDWCWSMDAYNV-------------------TDI---- 637

  Fly   676 TDPGLTPNGAKCGVDKMCVDQRC-----LPVDAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGF 735
            .|.|....|..|...|:|::..|     |..|...|        |.|:|||:||:..|||||.||
  Rat   638 PDYGDVQGGTYCAPKKVCMESICTGHATLQYDCHPQ--------EMCHGNGVCNNFKHCHCDAGF 694

  Fly   736 GGESCSKAGSGGSPDSGPATDP 757
            ....||..|:|||.||||...|
  Rat   695 SPPDCSSGGNGGSVDSGPVGKP 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	21/45 (47%)
		Reprolysin	269..464	CDD:279729	60/197 (30%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	60/195 (31%)
		Disintegrin	479..555	CDD:278623	36/79 (46%)
		ACR	558..701	CDD:214743	40/167 (24%)
Adam1a	NP_064463.1	Pep_M12B_propep	79..194	CDD:396235	23/60 (38%)
		Reprolysin	238..432	CDD:396140	60/198 (30%)
		DISIN	450..522	CDD:214490	36/80 (45%)
		ACR	524..660	CDD:214743	38/159 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020