DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and adam11

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_021335948.1	Gene:	adam11 / 567145	ZFINID:	ZDB-GENE-070808-3	Length:	788	Species:	Danio rerio

Alignment Length:	759	Identity:	235/759 - (30%)
Similarity:	351/759 - (46%)	Gaps:	91/759 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 STYTVIRPQVEHGRTKRSL-------------LTTLDATDG-----LHTPQISLSYTHEGKRVVV 95
            :.||     |||...:|.|             |.||..|||     :|..||:......|...|:
Zfish    37 NAYT-----VEHALPQRLLQRTDAEEELPHGHLGTLTKTDGDGTHPIHLAQITFLVKAFGIPFVL 96

  Fly    96 DLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTKTEVDLCHYQGHIRGKPESVVALSTCDGALD 160
            ||:.|..||.:::..|:.....        .:|.....:.|:|.||:||.|.|..|||||.| |.
Zfish    97 DLELNHDLLSSNYVERHFEKDG--------QSFQTLGGEHCYYHGHVRGVPRSWAALSTCHG-LQ 152

  Fly   161 GIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTNATCGY---DNHRDDHSHDYEKADGDNG 222
            |:..||..:|.|.|..:...:..|...:.:.|.:...|....|   |.....|.....:...|:.
Zfish   153 GMFSDGNFSYGIEPLHNSSDQTHDSKIIEEDASIKDANIHVVYRMADIRLMPHFSGSTRNSSDSD 217

  Fly   223 LGGGIPSLPLRLDGGEFSRTLLRKRRQADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQEN 287
            :....| :.:.....|.:..|.|.:|      |:.|||......:.||||::|.|..::...:.:
Zfish   218 INNDYP-VSMETSQLELTDGLRRAKR------QVRRGPRTVQSETKYVELLVVNDYDLFVQMRRS 275

  Fly   288 TKKVHQYCKGIANIINALY-VPLNIFVALVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLD 351
            :.:...:.|.:.|:.:|:| ..||..:.||.:..|:..|.:....|..:|||:|:.||  |..:.
Zfish   276 SPQTRNFAKAVVNMADAIYKEQLNTRIVLVAMETWSTQNMVSVGDDPLVTLRDFMKYR--KENIK 338

  Fly   352 HPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGM---- 412
            ..:|.|.||:...|.....|.|....||:....|||:...:..|  :|.|:...:|.|.||
Zfish   339 EKSDTAHLLSGRTFQSSRSGTAYIEGICSPTRGGGVNEYGNVGP--MAITLCQSLGQNLGMMWNK 401

  Fly   413 -EHDTSDCHCRDE--KCVMAASSTSFIPVNWSSCSIDQLTIAFSRGMNYCLRNKPERLFESPTCG 474
             .....||.|.|.  .|:| ..:..::|..:|.|||::......:|...||.|||.:|.:.|.||
Zfish   402 DRATAGDCRCPDPWLGCIM-EDTGYYLPRKFSRCSIEEYIQFLQQGGGSCLFNKPNKLLDPPECG 465

  Fly   475 NGFVEPGEQCDCGLPEHCE---NACCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAEN 536
            |||||.||:||||....|.   .|||  :.|.| :.:|.|:.|.||:  .|:.:..|..||:|.|
Zfish   466 NGFVEQGEECDCGSQVDCSRAGGACC--KKCTL-THDAMCSNGLCCN--RCKYEQRGVICRDAVN 525

  Fly   537 ECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWGPTGDNSEHCYNK-N 600
            :||:||.|:|:|..||.:|.:.|...||.|...|:.|.|::...||:.|||....: ..||.| |
Zfish   526 DCDVPETCSGDSSKCPHNVHKLDGYMCDAGLGRCYGGRCKTRDAQCQALWGHNAAD-RMCYEKLN 589

  Fly   601 TEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERLEFG---MESAAVLSHSYISHDRKIV 662
            .|||..||||.:..:..:::|.:|.|.||.|.|.::..:..:|   .||.::.    |.|..|.:
Zfish   590 IEGTERGNCGQDSSSHNWIQCNKQDVLCGFLLCTNITVKPRYGDLHGESTSLT----IYHQNKYL 650

  Fly   663 ACR--TALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPVDAVRQKGMGKPCPED-----CNGN 720
            .||  .|:::.|   ||.|...:|..||.:.||:|.|||||.......    ||..     |:.:
Zfish   651 DCRGGHAVLEDG---TDLGYVEDGTPCGPNMMCLDHRCLPVTTFNLSS----CPGSSFSLVCSDH 708

  Fly   721 GICNSRGHCHCDVGFGGESCSKAGSGGSPDSGPATDPNGSVGFK 764
            |.|::...|.||..:.|:.||....  .||..|   |:|...:|
Zfish   709 GTCSNEVKCICDSDYTGKDCSVYDP--IPDPQP---PDGPEKYK 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	40/127 (31%)
		Reprolysin	269..464	CDD:279729	58/202 (29%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	57/200 (29%)
		Disintegrin	479..555	CDD:278623	33/78 (42%)
		ACR	558..701	CDD:214743	52/148 (35%)
adam11	XP_021335948.1	Pep_M12B_propep	68..195	CDD:307618	39/135 (29%)
		Reprolysin	256..455	CDD:307535	58/203 (29%)
		Disintegrin	470..543	CDD:306668	33/77 (43%)
		ACR	547..688	CDD:214743	52/148 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9267
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950