DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and adam12b

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_021323120.1	Gene:	adam12b / 563275	ZFINID:	ZDB-GENE-070809-1	Length:	941	Species:	Danio rerio

Alignment Length:	1037	Identity:	324/1037 - (31%)
Similarity:	464/1037 - (44%)	Gaps:	192/1037 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LHLHLFLLPLLLLNTCLQQHILQPAEATA---FHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRT 63
            :.:|..:....|:|. |:..:|.....||   .|.|..|: :...||.:...|..:.|.:..|..
Zfish     1 MRIHRRMESWYLMNG-LRAFVLLVVGLTADISTHHSPDER-QLRSVLTKLEHYHTMVPLLLEGTE 63

  Fly    64 KR--SLLTTLDATDGLHTPQISLSYTH-----EGKRVVVDLQRNDLLLPNSHFLRYQNASRGATP 121
            :|  |.|.:       .||..||   |     ||:::::.:::|..|.. ||:........|.|
Zfish    64 QRPISWLRS-------RTPPASL---HILIQTEGQQLILSVEKNHGLFA-SHYTETHYREDGQT- 116

  Fly   122 GHVVTTFTKTEVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDH 186
                .|.|......|:|.|.::|...|.|.||||.| :.|.|:...:|..:.|..:   ...|.|
Zfish   117 ----VTSTHNSTMNCYYHGEVQGYVHSEVTLSTCSG-IRGFVLLENKTLMVEPAFE---PANDTH 173

  Fly   187 YLLKQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQAD 251
            .:.....:|..:.|||       |.|:.......|                  :|.||:..|
Zfish   174 VIYDGHHLHFPSGTCG-------HGHNISTVSNTN------------------TRGLLQSFR--- 210

  Fly   252 DSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALV 316
                 .|...:..|.:.||||:||.||:.::...::.:||.|....|||.::..|..|||.||||
Zfish   211 -----TRHKRDVQKTTKYVELIIVADNREFQKQGKDVEKVKQRLAEIANYVDKFYRVLNIRVALV 270

  Fly   317 GVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTY 381
            |:.:|::.::...:.|...||..||::|..||:...|:|||||::...|.|..:|.|....:||.
Zfish   271 GLEVWSDVDKCSVTQDPFTTLHEFLDWRKLKLLPQRPHDNAQLISGVYFQGTTIGMAPIMSMCTA 335

  Fly   382 EYSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSD--CHCR---DE-KCVMAASSTSFIPVNW 440
            |.|||:.|.||.|....|.|:|||:||||||.|||.:  |.||   |. .|:|..|:....|..:
Zfish   336 EQSGGIVMDHSDNALGAAVTLAHELGHNFGMNHDTPERGCGCRMTVDRGGCIMTPSTGYPFPTVF 400

  Fly   441 SSCSIDQLTIAFSRGMNYCLRNKPE--RLFESPTCGNGFVEPGEQCDCGLPEHCENACCNAQTCM 503
            |:||...|..:..:|:..||.|.||  .|:....||||::|.||:||||.||.|.|.||||.||.
Zfish   401 STCSKKDLVASLEKGVGMCLYNMPEVKMLYGGQKCGNGYIEEGEECDCGEPEECLNPCCNATTCT 465

  Fly   504 LHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQA 568
            |.. :|.||.|:||:  .|:.|.||:.|||:.|.|||||:|||.:.:|||:|:..|...|.....
Zfish   466 LKG-DAVCAHGQCCE--NCQLKPAGTPCRESSNSCDLPEFCTGTNPHCPANVYLHDGHACHNMDG 527

  Fly   569 YCFHGTCRSHSNQCRTLWGPTGDNSEH-CYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNCGML 631
            ||::|.|::|..||.|||||....:.. |:.: |:.|...||||.: ...:|.:||.:...||.:
Zfish   528 YCYNGICQTHEQQCITLWGPGAKPAPGICFERVNSAGDPYGNCGKD-AKGSFAKCEARDARCGKI 591

  Fly   632 HCIHLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQ 696
            .|.....|...|..:.::.::..:....::: ||...|.||....||||...|.||...|||:::
Zfish   592 QCQGGANRPVIGTNAVSIETNIPLQEGGRLL-CRGTHVYLGDDMPDPGLVLAGTKCAEGKMCLNR 655

  Fly   697 RCLPVDAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSGP---ATDPN 758
            :|..|...   |:.| |...|||.|.||::.:|||:..:....|.:||.|||.||||   |.|..
Zfish   656 QCQNVSVF---GVHK-CSAKCNGRGECNNKKNCHCEAHWAPPFCDRAGFGGSVDSGPMRQAADVR 716

  Fly   759 GSVGFKRFLYVLFFF---------VLPVVALFWF----LYHCYKNGMLTR-----GKLADNILKS 805
            ..|    .:.||.:.         |..:|.|...    |..|.|...|.:     .|.|...|:|
Zfish   717 VCV----LMCVLSYVTTADSSAVAVGSLVTLLCLLSAGLMLCLKRKALVQFLCANKKNAIQKLRS 777

  Fly   806 SGGSKPITTRTNQNGTGPPPSNGLLKSTPSSTDDMDSALLKSPSDSTPSAGLFGKFDGFTLRPLN 870
            .|                      .|.|| |.....|....||....||..|..:.|..: .|.:
Zfish   778 VG----------------------RKQTP-SPPQTQSVFRVSPQHKPPSLPLHSRADKMS-HPSS 818

  Fly   871 DASSPASNYNG------------------PNVAFVQP------TVQQDGPQRMA---------PP 902
            :...||.::..                  |....:||      ||....|:.:|         |.
Zfish   819 EPLLPAHSFQSLRRMPECPSRCQPVHISHPMPITLQPHRTLRATVVHTLPRHIAYTHTQDHDMPS 883

  Fly   903 PPVVKPGTAPIHP-------------PSPK--PEATWVRPAPALPPPNPGSTARPIISPPKL 949
            || .||  .|.||             |:|.  |..|..||.|::|.||     ||:   |:|
Zfish   884 PP-QKP--LPAHPLIRSHGMGRNVRIPAPLAIPIPTVPRPPPSIPLPN-----RPL---PRL 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	32/116 (28%)
		Reprolysin	269..464	CDD:279729	82/200 (41%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	81/198 (41%)
		Disintegrin	479..555	CDD:278623	43/75 (57%)
		ACR	558..701	CDD:214743	45/144 (31%)
adam12b	XP_021323120.1	Pep_M12B_propep	72..176	CDD:307618	32/123 (26%)
		ZnMc_adamalysin_II_like	222..422	CDD:239797	81/199 (41%)
		DISIN	447..515	CDD:214490	39/70 (56%)
		ACR	518..660	CDD:214743	45/143 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	153	1.000	Domainoid score	I4239
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	449	1.000	Inparanoid score	I1595
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0000154
OrthoInspector	1	1.000	-	-		otm24708
orthoMCL	1	0.900	-	-		OOG6_101958
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.970