DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and si:ch1073-396h14.1

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_689465.6	Gene:	si:ch1073-396h14.1 / 560975	ZFINID:	ZDB-GENE-070705-6	Length:	683	Species:	Danio rerio

Alignment Length:	671	Identity:	163/671 - (24%)
Similarity:	244/671 - (36%)	Gaps:	201/671 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 LSYTHE-----GKRVVVDLQRN--DLLLPNSHFLR------YQNASRGATPGHVVTTFTKTE-VD 134
            |||..|     ..|:..|...|  ||.|..|.|.|      ..:.:.|.|....|.:..::: ||
Zfish    40 LSYDRELVKQHQHRIRRDANPNKQDLHLDFSAFQREFHLRLTPDVNNGFTEDFKVQSENESQMVD 104

  Fly   135 LCH-YQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTN 198
            |.| |.|.:....:|....|..:|..:|.:.....|:::.|                 .:.:.|
Zfish   105 LSHIYSGVLEDDSKSSCQGSVLEGQFEGSITTSNGTFYVEP-----------------IERYKT- 151

  Fly   199 ATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLR-----LDGGEFSRTLL----------RKRR 248
                  .|.|.||..|.:.|.|:        .|||     ..|.|..:.||          |.:|
Zfish   152 ------THSDHHSIIYHEDDVDD--------TPLRSGHAGFCGAERLQNLLQNHQEQIPVSRSKR 202

  Fly   249 QADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNF---QENTKKVHQYCKGIANIINALYVP-- 308
            :.|.|           |.|..:.|  ..|::.||.|   :....:|..|.|.:.::.:.....
Zfish   203 KVDQS-----------KTSCLLHL--HTDHRYYKRFGSIEAIVAQVASYMKAVNDVYDKANFDGI 254

  Fly   309 --LNIFVALVGVVIWNE-SNEIEFSSDGD---LTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAG 367
              :|..|..:.|:...: |:.|..:..|.   |:|.:..|:....|        :.|||..:|:
Zfish   255 ELINFKVKFLTVITEEDPSSPISVTHVGPEKLLSLFSETNWNDFCL--------SYLLTDRDFS- 310

  Fly   368 GVVGKALKGP------ICT----------YEYSGGVSMQ---HSPNPAMVATTMAHEMGHNFGME 413
            ||:|.|.:|.      ||:          ...:|.|::|   |..:...|..|.|||:||:.|..
Zfish   311 GVLGLAWEGKADNWGGICSKMILKSGRNCSHNTGLVTLQTYGHYLSTKHVHLTFAHELGHSLGAP 375

  Fly   414 HDTSDCHCRD-------EKCVMAASSTSFIPVN---WSSCSIDQLTIAFSRGMNYCLRNKPERLF 468
            || .:.:|.|       .:.:|...:.|.|..|   :|.||:        |.|::.|..|.:..|
Zfish   376 HD-ENSNCGDLEVTSGKGRFLMFPKAASRIEENSDKFSPCSL--------RHMSHLLNVKKDTCF 431

  Fly   469 ---ESPTCGNGFVEPGEQCDCGLPEHCENACCNAQ------TCMLH-SKNATCATGECCDLTTCR 523
               :.|.|||..||.||:||.|..:  .:.||::.      .|.|. .|..:.:.|.||: :.|.
Zfish   432 VDSDQPICGNRIVEEGEECDVGHDD--SDPCCHSSKEPSGIECRLKLGKQCSPSQGLCCN-SQCV 493

  Fly   524 PKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHG-----TCRSHSN-QC 582
            .|.||..| |..:||.....|.|.|..||....:.|...|..|...|..|     .|..|:. ||
Zfish   494 FKKAGLMC-EGNSECRNKSVCAGSSAVCPEPPSKPDMTICSNGTRVCSSGECGLSLCALHNMVQC 557

  Fly   583 RTLWGPTGDNSEHCY-------NKNT-------------EGTRL---------GNCGY------- 611
            ..   |....:|.|:       ..||             .|.|:         ||.||
Zfish   558 DC---PGQSKTEKCHMCCQQRDKPNTCASTTSAVLLQYFSGKRVALAPGAPCSGNQGYCDQFKVC 619

  Fly   612 ---------NRLNKTFLRCEE 623
                     .||..:||:.:|
Zfish   620 RILDADGPIARLKNSFLKLDE 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	27/104 (26%)
		Reprolysin	269..464	CDD:279729	55/234 (24%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	55/232 (24%)
		Disintegrin	479..555	CDD:278623	27/82 (33%)
		ACR	558..701	CDD:214743	25/117 (21%)
si:ch1073-396h14.1	XP_689465.6	Pep_M12B_propep	55..156	CDD:279848	25/124 (20%)
		ZnMc	209..438	CDD:294052	58/248 (23%)
		Reprolysin_2	228..424	CDD:290307	49/213 (23%)
		Disintegrin	445..523	CDD:278623	27/81 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920