Protein Alignment Meltrin and adam17b

DIOPT Version :9

• Sequence 1: NP_001027575.1
• Gene: Meltrin / 3772109
• FlyBaseID: FBgn0265140
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: XP_021324312.1
• Gene: adam17b / 560657
• ZFINID: ZDB-GENE-041001-199
• Length: 843
• Species: Danio rerio
• Alignment Length: 1122
• Identity: 233/1122 - (20%)
• Similarity: 337/1122 - (30%)
• Gaps: 451/1122 - (40%)

  Fly     3 HLHLFLLPLLLLN-TCLQQHILQPAEATAFHQSEGEKSKAHPVLE-EFSTYTVIRPQVEHGRTKR 65
            ||...|....:|. :.||||.::..:..:  |:..|:......|: .|..|.....::
Zfish    31 HLSSLLSDFDVLQLSSLQQHSVRKRDVQS--QTHAERLLGFTALQRHFKLYLTTNTEL------- 86

  Fly    66 SLLTTLDATDGLHTPQISLSYTHEGKRVVV---------DLQRNDLLLPNSHFLRYQNASRGATP 121
                                :||:.|.|||         ::||.:.
Zfish    87 --------------------FTHDFKAVVVGEDGAQEVYEVQRENF------------------- 112

  Fly   122 GHVVTTFTKTEVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDH 186
                            :.||:.|:..|.|.....|......::.....|.|.|.........|..
Zfish   113 ----------------FTGHVIGEENSRVQAHIGDNDFTAHILTDEAEYNIEPLWRFTENTHDSR 161

  Fly   187 YL------LKQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTL-- 243
            .|      ::..........||           |..||....|...:          ..||.|
Zfish   162 LLVYRSEDIRNVSRLAATKVCG-----------YVSADASEVLPESV----------RVSRALDE 205

  Fly   244 --------LRKRRQADDSSQ-----LIRGPYNANKY----------SSYVELVIVVDNKVYKNFQ 285
                    :|:|||..|.|:     |:...|...|:          :..:||:..||: :|:
Zfish   206 DHQEEEGQVRERRQTVDHSKNTCPLLLVADYRFFKHMGRKEESTTLNYLIELIDRVDD-IYR--- 266

  Fly   286 ENTKKVHQYCKG--------IANIINALYVPLNIFVALVGV-----VIWNESNEIE-FSSDGDLT 336
             ||....:| ||        |.|:......|......:.|.     .:|:....:| ||.|
Zfish   267 -NTSWDDEY-KGYGVQIQQIIINMTPTQVEPGGAHFNMKGTPVKDKYVWDVKKLLEQFSID---- 325

  Fly   337 LRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSP-------- 393
                :...::::.|.|      |.|.::|..|.:|.|...| ....:.||:..:..|
Zfish   326 ----IADNASQVCLAH------LFTYQDFDEGTLGLAYVAP-SKPGFPGGLCSEKCPPSGNDNRA 379

  Fly   394 ---NPAMVAT--------------TMAHEMGHNFGMEHDTSD---CHCRDE---KCVMAASSTSF 435
               |..:.:|              ...||:|||||..||..|   |..|::   |.||...:.|.
Zfish   380 IYLNTGLTSTKNYGKTILTKEADLVTTHELGHNFGAVHDPDDMSYCAPREDQGGKYVMYPIAVSG 444

  Fly   436 IPVN---WSSCSIDQLTIAFSRGMNYCLRNKPERLFE---SPTCGNGFVEPGEQCDCGLPEHCEN 494
            ...|   :|:||  :::||..      ||.|....|:   |..|||..||.||:||.||.....:
Zfish   445 DHTNNKLFSNCS--KMSIAKR------LRAKASTCFKERNSNVCGNSRVEEGEECDPGLLHLNSD 501

  Fly   495 ACCNAQTCML------HSKNATCATGECCDLTTCRPKLAGSACRE-AENECDLPEYCTGESEYCP 552
            .||.| .|.|      ..:|:.|    |.|   ||.:.....|:| .|..|.....|:|....||
Zfish   502 LCCTA-NCKLKPGVQCSDRNSPC----CKD---CRFEKQNKVCQEPMEATCKGRSNCSGYGSECP 558

  Fly   553 ADVFRRDTEPC-DGGQAYCFHGTCRSHSNQCRTLWGPTGDNSEHCYNKNTEGTRLGNCGYNRLNK 616
            ......:...| |.|:  |.:|.|...   |..:             ||     |.:|.
Zfish   559 PPENLPNKTICVDNGR--CLNGECIPF---CEAV-------------KN-----LQSCA------ 594

  Fly   617 TFLRCEEQHVNCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPGLT 681
                |.|.|.:|.                                |.|:.
Zfish   595 ----CNETHNSCK--------------------------------VCCKD--------------- 608

  Fly   682 PNGAKCGVDKMCVDQRCLPVDAVRQKG------MGKPCPEDCNGNGICNSRGHC----------- 729
                |.||        |.|.  :..||      .||||..     |.|:..|.|
Zfish   609 ----KNGV--------CAPY--IGDKGSPLFLRKGKPCTV-----GFCDGAGKCMKQVQDVIERL 654

  Fly   730 -----HCDVGFGGESCSKAGSGGSPDSGPATDPNGSVGFKRFLYVLFFFVLPVVALFW----FLY 785
                 ..|:...|:..             |.:..|||       |:|..      |||    .|.
Zfish   655 WDFIEKLDINTFGKFL-------------ADNIVGSV-------VVFSL------LFWIPLSILV 693

  Fly   786 HCYKNGMLTRGKLADNILKSSGGSKPITTRTNQNGTGPPPSNGLLKSTPSSTDDMDSALLKSPSD 850
            ||....:..:.:|:         :||:..          |||..|.   ||.:.....:.|.||
Zfish   694 HCVDKKLDQQYELS---------TKPLFY----------PSNAELL---SSLESASVRIFKPPS- 735

  Fly   851 STPSAGLFGKFDGFTLRPLNDASSPASNYNGPNVAFVQPTVQQDGP-QRMAPPPPVVKPGTAPIH 914
               |||                            :.|.|.....|| |...||..:.:...|||.
Zfish   736 ---SAG----------------------------SSVVPRFHACGPLQTSTPPVSISQVAPAPIQ 769

  Fly   915 PPSPKPEATWVRPAPALPPPNPGSTARPIISPPKLDSSTLTMVPLKD---------STEDLSPSR 970
            .|:|.|          ||...|...| .|...|..||. |..|..:|         |.:||:.:|
Zfish   770 TPTPCP----------LPNIEPQRMA-TIKEDPSYDSH-LDQVLGEDFPTSGSVSRSFDDLTENR 822

  Fly   971 -SAPPVPLHADPKLNVK 986
             :|....::..|:.|.|
Zfish   823 ENAMSFRVNRHPQSNSK 839

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	16/118 (14%)
		Reprolysin	269..464	CDD:279729	57/242 (24%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	56/240 (23%)
		Disintegrin	479..555	CDD:278623	26/82 (32%)
		ACR	558..701	CDD:214743	21/143 (15%)
adam17b	XP_021324312.1	Pep_M12B_propep	46..150	CDD:307618	25/167 (15%)
		ZnMc_TACE_like	226..479	CDD:239798	63/281 (22%)
		Disintegrin	486..560	CDD:306668	26/81 (32%)
		ADAM17_MPD	583..643	CDD:318829	25/156 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920