DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and Adam39

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001020551.3	Gene:	Adam39 / 546055	MGIID:	3045694	Length:	756	Species:	Mus musculus

Alignment Length:	695	Identity:	209/695 - (30%)
Similarity:	325/695 - (46%)	Gaps:	116/695 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 VTTFTK----------TEVDLCHYQGHIRGKPESVVALSTCDGALDGIV-IDGRQTYFIHPHIDG 178
            |.|:||          .:.| |:|.||:.|.|||:||::||.|...||: |:|  |.:
Mouse   104 VFTYTKQGALHKDQPYVQND-CYYHGHMDGDPESMVAITTCYGGFQGILQING--TVY------- 158

  Fly   179 RGRLQDDHYLLKQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTL 243
                          ::.|.|.:..::       |...|.|.:.     ....|:|.   ..:..:
Mouse   159 --------------EIKPKNLSSTFE-------HLVHKMDSEE-----TELYPMRC---ALTEEI 194

  Fly   244 LRKRR-QADDSSQLIRGPYNA-NKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALY 306
            .::.: |.:::..|::..|.. ..:.|:::|.:|||.:.......||..|......|.||||.:|
Mouse   195 AKQMKLQQNENPTLMQSHYEGWWTHRSFLDLALVVDCERVHYHNNNTSHVLVEVFTIVNIINNIY 259

  Fly   307 VPLNIFVALVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVG 371
            ..|::.:.|:||.:|||.|.::..:..:. |..|.::::..|....|||.|.:....:|. ..:|
Mouse   260 ETLDVELVLLGVEMWNEKNHVQGRNINEF-LVEFCDWKARSLNFRIPNDIAHIFVNLDFQ-IYLG 322

  Fly   372 KALKGPICTYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSDCHCRDEKCVMAASSTSFI 436
            .|..|.:|...|:.||......|.......:|||:|||.|||||:|.|.|....|:||.:....
Mouse   323 VAYVGGVCLPSYNCGVDCLLGGNLFYFGHIIAHEIGHNLGMEHDSSSCTCGRNVCLMAPADNGI- 386

  Fly   437 PVNWSSCSIDQLTIAFSRGMNYCLRNKPERLFESPTCGNGFVEPGEQCDCGLPEHCENACCNAQT 501
             ..:|:||.......:..........|...:.....||:|.|:.|||||||..::|.:..|..::
Mouse   387 -SKFSNCSYSYFWTKYPTAKCMHKEKKSIGILRGKLCGDGVVDDGEQCDCGSAKNCADDPCCKRS 450

  Fly   502 CMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPC-DG 565
            |.| ...|.||.|.||..  |:...||:.||:.:|||||||:|.|.|..||.||:..|..|| ||
Mouse   451 CTL-KDGAACAFGLCCKY--CQIMEAGTVCRKRDNECDLPEWCNGHSHKCPNDVYLLDGSPCRDG 512

  Fly   566 GQAYCFHGTCRSHSNQCRTLWGPTGDNSEH-CYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNC 628
            |  ||:...|.:...||:.::|....:::| ||.: ||:|.|.||||  .:...:|||.:..:.|
Mouse   513 G--YCYEKRCNNRDKQCKQIFGKEARSADHSCYRELNTQGDRFGNCG--MIRDAYLRCHDPDILC 573

  Fly   629 GMLHCIHLNERLEFGMESAAVLSHSYISHDRKI--VACRTALVDLGLQTTDPGLTPNGAKCGVDK 691
            |.:.|.::. |:.|      :..||.: |...:  |.|.......|:...|.|:..:|..||.:.
Mouse   574 GRVQCENVT-RIPF------LRDHSTV-HWTHLNGVTCWGTDYHFGMTIPDIGIVKDGTDCGPEH 630

  Fly   692 MCVDQRCLPVDAVRQKGMGKP-----C-PEDCNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPD 750
            :|::::|          :.||     | |..|:..|:||:..||||:.|:....|.|:|.|||.|
Mouse   631 VCINKKC----------VSKPIWTSQCSPTTCSMKGVCNNLHHCHCNRGWDPPHCLKSGLGGSID 685

  Fly   751 SGPATDPN-------GSVGFKRFLYVLFFFVLPVVALFWFLYHCY 788
            |||   ||       .|:|              :|:|||.|:.|:
Mouse   686 SGP---PNYNEKKHKKSIG--------------LVSLFWILFACF 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	23/59 (39%)
		Reprolysin	269..464	CDD:279729	57/194 (29%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	57/192 (30%)
		Disintegrin	479..555	CDD:278623	34/75 (45%)
		ACR	558..701	CDD:214743	44/147 (30%)
Adam39	NP_001020551.3	Pep_M12B_propep	69..173	CDD:279848	26/99 (26%)
		Reprolysin	222..409	CDD:279729	57/190 (30%)
		ZnMc_adamalysin_II_like	222..408	CDD:239797	57/189 (30%)
		Disintegrin	428..501	CDD:278623	34/75 (45%)
		ACR	504..640	CDD:214743	44/157 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0000154
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920