DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and ADAM22

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_006716091.1	Gene:	ADAM22 / 53616	HGNCID:	201	Length:	1024	Species:	Homo sapiens

Alignment Length:	1024	Identity:	272/1024 - (26%)
Similarity:	423/1024 - (41%)	Gaps:	190/1024 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 HQSEGEKSKAHPVLEEFSTYTVIR-----PQVEHGRTKRSLLTTLDATDGLHTPQISLSYTHEGK 91
            ::|.||....|..|:     |.:|     ||:                  .|..|.|......|.
Human   109 YRSGGEDESRHDALD-----TRVRGDLGGPQL------------------THVDQASFQVDAFGT 150

  Fly    92 RVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTKTEV---DLCHYQGHIRGKPESVVALS 153
            ..::|:..|..||.:.:..|           |:.......||   :.|:|||||||.|:|.||||
Human   151 SFILDVVLNHDLLSSEYIER-----------HIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALS 204

  Fly   154 TCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTNATCGYDNHRDDHSHDYEKAD 218
            ||.| |.|:..||..||.|.|  :.....|:|.:      .|....:..::...||...::::
Human   205 TCHG-LHGMFYDGNHTYLIEP--EENDTTQEDFH------FHSVYKSRLFEFSLDDLPSEFQQ-- 258

  Fly   219 GDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKN 283
                         :.:...:|    :.|.|......||.|.|.|..:.:.|:||:||.|:.::|.
Human   259 -------------VNITPSKF----ILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKK 306

  Fly   284 FQENTKKVHQYCKGIANIINALYV-PLNIFVALVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTK 347
            .:.:....:.|.|.:.|:.:.:|. .|...:.||.:..|...|:...|.:..:|||.|:.||  :
Human   307 HRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYR--R 369

  Fly   348 LVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGM 412
            ..:...:|...|.:...|.....|.|..|.||:....|||:  ......::|.|:|..:.||.|:
Human   370 DFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVN--EFGKTDLMAVTLAQSLAHNIGI 432

  Fly   413 EHD-----TSDCHCRD--EKCVMAASSTSFIPVNWSSCSIDQLTIAFSRGMNYCLRNKPERLFES 470
            ..|     :.:|.|.|  ..|:| ..:..::|..::.|:|::.....:.|...||.|||.:|.:.
Human   433 ISDKRKLASGECKCEDTWSGCIM-GDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDP 496

  Fly   471 PTCGNGFVEPGEQCDCGLPEHC--ENA-CCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACR 532
            |.|||||:|.||:||||.|..|  |.| ||  :.|.| ::::.|:.|.||  ..|:.:..|:.||
Human   497 PECGNGFIETGEECDCGTPAECVLEGAECC--KKCTL-TQDSQCSDGLCC--KKCKFQPMGTVCR 556

  Fly   533 EAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWGPTGDNSE-HC 596
            ||.|:||:.|.|:|.|..|..::.:.|...|||.|..||.|.|::...||:.:||.....|: :|
Human   557 EAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYC 621

  Fly   597 YNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERLEFGMESAAVLSHSYISHDRK 660
            |.| |.|||..||||.::  .|:::|.::.|.||.|.|.::......|.....:.|...:...|.
Human   622 YEKLNIEGTEKGNCGKDK--DTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRT 684

  Fly   661 IVACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPVDAVR-------QKGMGKPCPEDCN 718
            : .|....|.|. :..|.|...:|..||...||::.|||||.:..       ::|      ..|:
Human   685 L-NCSGGHVKLE-EDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEG------TICS 741

  Fly   719 GNGICNSRGHCHCDVGFGGESCSK-AGSGGSPDSGPATDPNGSVGFKRFLYVLFFFVLPVVALFW 782
            |||:|::...|.|:..:.|..|:. ........:|.....||..|....:.::...:|.:..:..
Human   742 GNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILG 806

  Fly   783 FLYHCYKN----GMLTRGKLADNILKSSGGSK-----PITTRTNQNGTGPPPSNGL-------LK 831
            .....|||    ..|.:|   |.:.|...|..     |....||...:....||||       :.
Human   807 ITAWGYKNYREQRQLPQG---DYVKKPGDGDSFYSDIPPGVSTNSASSSKKRSNGLSHSWSERIP 868

  Fly   832 STPSSTDDMDSALLKSPSDSTPSAGLFGKFDGFTLRPLNDASSPASNYNGPNVAFVQPTVQQDGP 896
            .|...:|..::...:|.|......|...|..|...||.::::........|..:..| ||...|
Human   869 DTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTEREPQAPEPGHSLAQ-TVPSQG- 931

  Fly   897 QRMAPPPPVVKPGTAPIHPPSPKPE-------------------ATWVRPAPALPPPNPGSTARP 942
                     :.||      .|..|:                   |.||.....       :|..|
Human   932 ---------ISPG------GSDSPQTGSLDHRYLNPWFKRDYNVAKWVEDVNK-------NTEGP 974

  Fly   943 ---IISPPKLDSSTLTMVPLKDSTEDLSPSRS----APPVPLHADPKLN 984
               .:||.|..||         ||..::.||.    .||:| ..|.|:|
Human   975 YFRTLSPAKSPSS---------STGSIASSRKYPYPMPPLP-DEDKKVN 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	36/112 (32%)
		Reprolysin	269..464	CDD:279729	53/202 (26%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	52/200 (26%)
		Disintegrin	479..555	CDD:278623	33/78 (42%)
		ACR	558..701	CDD:214743	48/144 (33%)
ADAM22	XP_006716091.1	Pep_M12B_propep	127..239	CDD:279848	43/149 (29%)
		Reprolysin	291..490	CDD:279729	53/203 (26%)
		ZnMc_adamalysin_II_like	291..488	CDD:239797	52/201 (26%)
		Disintegrin	505..579	CDD:278623	33/78 (42%)
		ACR	582..723	CDD:214743	48/144 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9321
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.950