DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and adam9

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001004678.1	Gene:	adam9 / 447940	ZFINID:	ZDB-GENE-040912-127	Length:	271	Species:	Danio rerio

Alignment Length:	279	Identity:	81/279 - (29%)
Similarity:	122/279 - (43%)	Gaps:	52/279 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 EFSTYTVIRPQVEHGRTKRSLLTTLDATDGLHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLR 111
            :.|:|.|..|: ...|.:|:    .|:.|     ::|.....:||..||.|:||:||||.. |..
Zfish    36 QLSSYEVTVPR-RISRQRRN----QDSAD-----KVSYIIQAQGKEHVVILERNELLLPED-FTV 89

  Fly   112 YQNASRGATPGHVVTTFTKTEVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHI 176
            |..|..|:    :||....| .|.|||.|:|.....|..|||.|.| |.|::.....::.|.|.
Zfish    90 YSYAKDGS----LVTEKLNT-TDHCHYSGYIEDVEGSSAALSLCSG-LRGVIHTEGTSFGIEPL- 147

  Fly   177 DGRGRLQDDHYLLKQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPL-----RLDG 236
              .|...|:|.:.:..|:......||     ..||::::....        |..|:     .:..
Zfish   148 --EGSPSDEHLVYRLEDVQTQPLNCG-----TPHSYNHDDQSS--------PRQPIISHTHNITF 197

  Fly   237 GEFSRTLLRKRRQADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANI 301
            |:....|.|||.....              :.||||::||||:.|.....|...|.:....|||.
Zfish   198 GQAGSHLRRKRAVLHQ--------------THYVELLMVVDNERYNYKNRNHTAVREEVVQIANY 248

  Fly   302 INALYVPLNIFVALVGVVI 320
            ::::|:||||.:.|||:.|
Zfish   249 VDSMYIPLNIRIVLVGLEI 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	37/109 (34%)
		Reprolysin	269..464	CDD:279729	23/52 (44%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	23/52 (44%)
		Disintegrin	479..555	CDD:278623
		ACR	558..701	CDD:214743
adam9	NP_001004678.1	Pep_M12B_propep	51..155	CDD:279848	40/122 (33%)
adam9	NP_001004678.1	ZnMc	216..>267	CDD:294052	22/50 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	153	1.000	Domainoid score	I4239
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	449	1.000	Inparanoid score	I1595
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24708
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	9.100