DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meltrin and Tace

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_733334.1	Gene:	Tace / 43558	FlyBaseID:	FBgn0039734	Length:	732	Species:	Drosophila melanogaster

Alignment Length:	809	Identity:	176/809 - (21%)
Similarity:	267/809 - (33%)	Gaps:	273/809 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LHLFLLPLLLLNTCLQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRTKRSLL 68
            :.:|...|.:.|....|..|:..|  .||:.:             ..:.|::...:|
  Fly    14 ISVFFACLFVENCAALQKTLRHYE--IFHKDD-------------VVHRVVKRGAKH-------- 55

  Fly    69 TTLDATDGLHTPQISLSYTHEGK--RVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTKT 131
                :|:..:|.: .:.:|..||  |:::...|:.|   :|.|..|...:.|          .:|
  Fly    56 ----STNPFNTIK-EVEFTTLGKNFRLILHPHRDVL---HSKFRAYAVDADG----------NET 102

  Fly   132 EVDLCH---YQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHP---HIDGRGRLQDDHYLLK 190
            .|.:.|   |.|.:.|:.||.|.....||.:...:....:||.|.|   |:....:.....|...
  Fly   103 VVHMDHDSFYSGRVFGELESSVRAHIEDGTMTMSIHLPEETYHIEPSWRHLPEAKKDTMVAYKAS 167

  Fly   191 QADMHPTNA-----TCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTL-----LR 245
            ...:|...|     ||||..            :|            |.|:..|...||     .|
  Fly   168 DVKVHKNEAGATPKTCGYIK------------EG------------LELEDKEHGDTLDNELHTR 208

  Fly   246 KRRQADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQE----NTKKVHQYCKGIANIINALY 306
            ::||:|.        |......:...|::|.|   |:.|||    |||....|...:.:.::.:|
  Fly   209 EKRQSDQ--------YEYTPTKTRCPLLLVAD---YRFFQEMGGGNTKTTINYLISLIDRVHKIY 262

  Fly   307 VPLNIFVALVGVVIWNESNEIE-FSSDGDLTLRNFLNYRSTKLVLDHPNDN-------------- 356
                      ...:|.:.::.| |...|.:..:..::...|:|.....:.|
  Fly   263 ----------NDTVWQDRSDQEGFKGMGFVIKKIVVHSEPTRLRGGEAHYNMIREKWDVRNLLEV 317

  Fly   357 ------------AQLLTKENFAGGVVGKALKGP--------ICTYEY---------SGGVSMQHS 392
                        |.|.|...|.||::|.|..|.        |||.||         :.|:|...:
  Fly   318 FSREYSHKDFCLAHLFTDLKFEGGILGLAYVGSPRRNSVGGICTPEYFKNGYTLYLNSGLSSSRN 382

  Fly   393 PNPAMVAT-----TMAHEMGHNFGMEHDTSDCHCRDEKCVMAASSTSFIPVNWSSCSIDQLTIAF 452
            .....|.|     ..|||.|||:|.|||.....|...    |:...||:...:|....|.....|
  Fly   383 HYGQRVITREADLVTAHEFGHNWGSEHDPDIPECSPS----ASQGGSFLMYTYSVSGYDVNNKKF 443

  Fly   453 S----RGMNYCLRNKPERLFESPT---CGNGFVEPGEQCDCGLPEHCEN-ACCNAQTCMLHSKNA 509
            |    |.:...|:.|..|.|..|.   |||..||..||||.||....:| :||:....:..::.|
  Fly   444 SPCSLRSIRKVLQAKSGRCFSEPEESFCGNLRVEGDEQCDAGLLGTEDNDSCCDKNCKLRRNQGA 508

  Fly   510 TCA--TGECCDLTTCRPKLAGSACREAE-NECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCF 571
            .|:  ...||.  .|:...:|..||||: ..|:....|||....||......|
  Fly   509 MCSDKNSPCCQ--NCQFMASGMKCREAQYATCEQEARCTGAHAECPKSPAMAD------------ 559

  Fly   572 HGTCRSHSNQCRTLWGPTGDNSEHCYNKNTEGTRLGNC-GYNRLNKTFLRCEEQHVNCGMLHCIH 635
             ||......|||.                      |.| .|         ||.|    |:..|:
  Fly   560 -GTTCQERGQCRN----------------------GKCVPY---------CETQ----GLQSCM- 587

  Fly   636 LNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLP 700
                       ..:::.          ||:                    :|  .:|.:::.|.|
  Fly   588 -----------CDIIAD----------ACK--------------------RC--CRMSINETCFP 609

  Fly   701 VDAVRQKGMGKPCPEDCNGNGICNSRGHC 729
            |:.......|.||.     .|.|| :|.|
  Fly   610 VEPPDVLPDGTPCI-----TGFCN-KGVC 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	26/114 (23%)
		Reprolysin	269..464	CDD:279729	57/251 (23%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	57/249 (23%)
		Disintegrin	479..555	CDD:278623	26/79 (33%)
		ACR	558..701	CDD:214743	19/143 (13%)
Tace	NP_733334.1	Pep_M12B_propep	50..162	CDD:279848	29/137 (21%)
		ZnMc_TACE_like	223..470	CDD:239798	61/263 (23%)
		Reprolysin_2	244..456	CDD:290307	48/225 (21%)
		Disintegrin	477..552	CDD:278623	24/76 (32%)
		ADAM17_MPD	576..633	CDD:271205	21/120 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.950