DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meltrin and Kul

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001287589.1	Gene:	Kul / 43501	FlyBaseID:	FBgn0039688	Length:	1537	Species:	Drosophila melanogaster

Alignment Length:	1246	Identity:	272/1246 - (21%)
Similarity:	427/1246 - (34%)	Gaps:	370/1246 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 NKVYKN--FQENTK-----------KVHQYCKGIANIINALYVPLNIFVALVGVVIWNESNEIEF 329
            |.:|:|  |..:.|           |||.        :||:..|...|....||     ...:|.
  Fly   513 NTIYRNTDFNNDGKPDNITFMIKRIKVHN--------MNAMKDPSYRFPGNYGV-----EKFLEL 564

  Fly   330 SSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKA----LK--GPIC--TYEYSGG 386
            .|:.|        |.:..|        |.:.|..:|..|.:|.|    ||  |.:|  ...|.|.
  Fly   565 FSEED--------YDAFCL--------AYMFTYRDFEMGTLGLAWTGDLKNAGGVCEKNGHYRGS 613

  Fly   387 VSM------------QHSPNPAMVATTMAHEMGHNFGMEHDTSDC--HCRDEKCVMAASSTSFIP 437
            :..            :|.| ||:...|:|||:|||||..||...|  ...|...:|.|.:||...
  Fly   614 LKSLNTGIVTLLNYGKHVP-PAVSHVTLAHEIGHNFGSPHDPEQCTPGGEDGNFIMFARATSGDK 677

  Fly   438 VN---WSSC---SIDQLTIAFSRGMNYCLRNKPERLFESPTCGNGFVEPGEQCDCGLPEHCENAC 496
            .|   :|:|   ||:.:..|.:|.|..|. .:|    :|..||||.||||||||||..|.|:::|
  Fly   678 KNNNKFSTCSLKSIEPVLNAKARSMKGCF-TEP----QSSICGNGVVEPGEQCDCGWEEDCKDSC 737

  Fly   497 C---------NAQTCMLHSKNATC--ATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEY 550
            |         :...|.| :.:|.|  :.|.|| .|.|:.|. |..||: :|.|..|.:|.|....
  Fly   738 CFPMSRQPRLDETPCTL-TPHARCSPSQGPCC-TTDCKLKF-GDKCRD-DNGCRDPSFCDGRVPQ 798

  Fly   551 CPADVFRRDTEPCDGGQAYCFHGTCRSH------SNQCRTLWGPTGDNSEHC------------- 596
            ||..|.:.:...|: .:..|:.|.|...      ...|:.:.||..|..:.|
  Fly   799 CPPSVNKPNKTICN-KEFVCYMGDCTGSICLAYGLESCQCIPGPQDDRIKSCELCCKLPGEDSPC 862

  Fly   597 ----------------YNKNTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERLEFGME 645
                            |:|  .||...:  ||.....|.:|.|...: |.|..:   .:|....|
  Fly   863 RSSFEWNEAPFDVPDMYSK--PGTPCND--YNGYCDVFQKCREVDPS-GPLATL---RKLLLSEE 919

  Fly   646 SAAVLSHSYISHDRKIVACRT--ALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPVDAVRQKG 708
            |.|... .::.|:...||...  .::.|.|.|.   |....:...:..:.:.... ..:.||
  Fly   920 SIASFK-KWMQHNWYTVALAAVGVILLLALSTK---LLAKRSNLKLKSVTIIHSA-TTETVR--- 976

  Fly   709 MGKPCPEDCNGNGICNSRGHCHCDV--------GFGGESCSKAGSGGSPDSGPATDPNGSVGFKR 765
                .||  |.||:.     .|..|        ...||...|.|:|....:..|      ||
  Fly   977 ----LPE--NNNGVI-----VHTAVRTKVPFKKKVRGERTKKPGTGAGVTAAAA------VG--- 1021

  Fly   766 FLYVLFFFVLPVVALFWFLYHCYKNGMLTRGKLADNILKSSGGSKPITTRTNQNGTGPPPSNGLL 830
                                        ||     |..|||...:|                  .
  Fly  1022 ----------------------------TR-----NAAKSSANPEP------------------K 1035

  Fly   831 KSTPSSTDDMDSALLKSPSDSTPSAGLFGKFDGFTLRPLNDASSPASNYNGPNVAFVQPTVQQDG 895
            |:|.|.......:..:.|..|:...|..       ::.:.|.|:  .|.||.:.:.:..|..
  Fly  1036 KTTRSQAMAKKKSFEEEPKKSSKKVGKH-------MKEIIDYSN--RNNNGDDASNLSTTNN--- 1088

  Fly   896 PQRMAPPPPVVKPGTAPIHPPSPKPEATWVRPAPALPPP----NPGSTARPIISPPKLDSSTLTM 956
                              |..:......|:..:|.:..|    ...|..|.:
  Fly  1089 ------------------HTNTFGKVQKWLLESPIVAQPLSHIEHSSRVRKV------------- 1122

  Fly   957 VPLKDSTEDLSPSRSAPPVPLHADPKLNVKRDGTIRRFASFLKKEEKPPLKEKTYIDRE-RLRTL 1020
                     :|.|:|.|...:...|: ..|..|.:......|:...|||.|....:.:: :::|.
  Fly  1123 ---------MSKSQSTPERLVQKTPQ-KTKSMGNLSNEKVKLQVVYKPPFKFSLRLSKKPKVKTH 1177

  Fly  1021 EISAPMPVPAAPQAESSNSDSETTPREEETQNLVKRAQSM---------RSPTKKAPLQSFGSMR 1076
            .:.|.:. |...|..|:.:..:::.:|..|:  .||:..:         :..|...|  ::.:::
  Fly  1178 VVGAGVR-PKRSQKTSNRTGGQSSSKEVSTR--AKRSALLLCNEAEDDNQILTLNEP--NYETLK 1237

  Fly  1077 SPPGLPRP-KSGQVNSNGASRPKSPPPRPPPVVVKKTNSISSSGYQRPVSTAQRSVENTYDDCEF 1140
             ||..||. :....|.:..:...|..|.....|...:.:.:|.....|| ||||
  Fly  1238 -PPTPPRSMEHCYENVDMQAEASSSKPSSSSKVAPSSQNRASLEVTPPV-TAQR----------- 1289

  Fly  1141 VENEVRASNDDIYSVIDEIPPAAQTLKRSDLVANRASNGSDMGLLNEIVNELEKINGDSIYSGKP 1205
              |..|.||    |:....|.||...:.|...:...:...:.|....::|..:.::.:...|...
  Fly  1290 --NSYRRSN----SLSTHNPFAAAPRRSSSKASGSVNLTRNFGSTQNLINLSQNLSKNKKRSSLN 1348

  Fly  1206 VAAAASAAQPTPADPP----KSPQRPAPPKPASSVLEEKAANASASTYHRPPPANAPVARVKPTV 1266
            :.|:.|.|..:..|||    .||||.:   .:::.|...::.:|:.....||..|
  Fly  1349 LKASGSGATRSGKDPPTMGVASPQRRS---SSNANLRRDSSVSSSKAVPVPPTRN---------- 1400

  Fly  1267 ADKSQAQAQAQPSMSSF----KPAAGG---NVGQSQPAPVVQLAKRSSSGSMSGVTNYARPKSFM 1324
                        |.:||    :.:.||   |...|..||....:::|||.:.:.          .
  Fly  1401 ------------SRNSFSNIPRASLGGANSNAAVSTGAPPPSFSRQSSSSTATS----------S 1443

  Fly  1325 KSTTKTLPNGTAGASTTAPSATIQKPKPLSAKPSF-----SGGGAGGVLGKRANGGAAPTPPTVK 1384
            .|.|..:.:|.|...:.:.||..:.|.....:.|.     ...|.|...||   .|||.|.....
  Fly  1444 SSITAGVTSGVALQQSASTSAMQRHPPSQPTRRSLHNFRTRSTGTGAAAGK---PGAAVTSAAAT 1505

  Fly  1385 AATLAAAPKSN 1395
            :|..::|..||
  Fly  1506 SAGASSAAASN 1516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848
		Reprolysin	269..464	CDD:279729	61/226 (27%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	61/224 (27%)
		Disintegrin	479..555	CDD:278623	33/86 (38%)
		ACR	558..701	CDD:214743	31/179 (17%)
Kul	NP_001287589.1	Pep_M12B_propep	72..174	CDD:279848
		ZnMc_TACE_like	479..713	CDD:239798	63/234 (27%)
		Reprolysin_2	502..696	CDD:290307	57/212 (27%)
		Disintegrin	720..803	CDD:278623	33/86 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.920