DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Meltrin and ADAM11

DIOPT Version :9

Sequence 1:NP_001027575.1 Gene:Meltrin / 3772109 FlyBaseID:FBgn0265140 Length:1407 Species:Drosophila melanogaster
Sequence 2:XP_005257430.1 Gene:ADAM11 / 4185 HGNCID:189 Length:774 Species:Homo sapiens


Alignment Length:689 Identity:215/689 - (31%)
Similarity:325/689 - (47%) Gaps:83/689 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 LHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTKTEVDLCHYQGH 141
            :|..|:|...........:||:.|..||.:.:..|:  .||..|..|     :....|.|:|||.
Human    81 VHLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERH--FSREGTTQH-----STGAGDHCYYQGK 138

  Fly   142 IRGKPESVVALSTCDGALDGIVIDGRQTYFIHP-HIDG-----RGRLQDDHYLLKQADMHPTNAT 200
            :||.|.|..|||||.| |.|:..||..||.:.| .:.|     :|.|.   :|:.:..:.|....
Human   139 LRGNPHSFAALSTCQG-LHGVFSDGNLTYIVEPQEVAGPWGAPQGPLP---HLIYRTPLLPDPLG 199

  Fly   201 CGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDSSQLIRGPYNANK 265
            |                 .:.|....:|:     .....:|..||::|      |:.||....:.
Human   200 C-----------------REPGCLFAVPA-----QSAPPNRPRLRRKR------QVRRGHPTVHS 236

  Fly   266 YSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALY-VPLNIFVALVGVVIWNESNEIEF 329
            .:.||||:::.|:::::..:::......:.|.:.|:.:.:| ..||..:.||.:..|.:.::|:.
Human   237 ETKYVELIVINDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQV 301

  Fly   330 SSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPN 394
            ..|...||...:.||  :..|..|:|...|.:...|.....|.|..|.||:..:.|||:  ...|
Human   302 QDDLLETLARLMVYR--REGLPEPSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVN--EYGN 362

  Fly   395 PAMVATTMAHEMGHNFGM---EHDTS--DCHCRD--EKCVMAASSTSF-IPVNWSSCSIDQLTIA 451
            ...:|.|:|..:|.|.||   :|.:|  ||.|.|  ..|:|  ..|.| :|..:|.||||:....
Human   363 MGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIM--EDTGFYLPRKFSRCSIDEYNQF 425

  Fly   452 FSRGMNYCLRNKPERLFESPTCGNGFVEPGEQCDCGLPEHCENA---CCNAQTCMLHSKNATCAT 513
            ...|...||.|||.:|.:.|.|||||||.||:||||..:.|..|   ||  :.|.| :.:|.|:.
Human   426 LQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCC--KKCTL-THDAMCSD 487

  Fly   514 GECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSH 578
            |.||  ..|:.:..|.:||||.||||:.|.|||:|..||.::.:.|...||..|..|:.|.|::.
Human   488 GLCC--RRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTR 550

  Fly   579 SNQCRTLWGPTGDNSEHCYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERLEF 642
            ..||:.|||....: ..||.| |.|||..|:||  |....:::|.:|.|.||.|.|::::.....
Human   551 DRQCQVLWGHAAAD-RFCYEKLNVEGTERGSCG--RKGSGWVQCSKQDVLCGFLLCVNISGAPRL 612

  Fly   643 GMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPVDAVRQK 707
            | :....:|.....|..|.:.||...|.|. ..:|.....:|..||.:.:|:|.||||..|..  
Human   613 G-DLVGDISSVTFYHQGKELDCRGGHVQLA-DGSDLSYVEDGTACGPNMLCLDHRCLPASAFN-- 673

  Fly   708 GMGKPCPED-----CNGNGICNSRGHCHCDVGFGGESCS 741
              ...||..     |:.:|:|::.|.|.|...:.|:.||
Human   674 --FSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCS 710

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MeltrinNP_001027575.1 Pep_M12B_propep 64..174 CDD:279848 34/96 (35%)
Reprolysin 269..464 CDD:279729 60/203 (30%)
ZnMc_adamalysin_II_like 269..462 CDD:239797 59/201 (29%)
Disintegrin 479..555 CDD:278623 35/78 (45%)
ACR 558..701 CDD:214743 47/143 (33%)
ADAM11XP_005257430.1 Pep_M12B_propep 76..188 CDD:279848 38/117 (32%)
Reprolysin 239..438 CDD:279729 60/204 (29%)
ZnMc_adamalysin_II_like 239..436 CDD:239797 59/202 (29%)
Disintegrin 453..527 CDD:278623 35/78 (45%)
ACR 530..668 CDD:214743 46/142 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 72 1.000 Domainoid score I9321
eggNOG 1 0.900 - - E1_KOG3607
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D162519at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11905
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4147
SonicParanoid 1 1.000 - - X50
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.950

Return to query results.
Submit another query.