DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and Adam34l

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001020411.1	Gene:	Adam34l / 384813	MGIID:	3647273	Length:	736	Species:	Mus musculus

Alignment Length:	798	Identity:	226/798 - (28%)
Similarity:	361/798 - (45%)	Gaps:	120/798 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 FSTYTVIRPQVEHGRTKRSLL------TTLDATDGLHTPQISLSYTHE--GKRVVVDLQRNDLLL 104
            ||.|:.|      |..|.|.|      ..:..|.|.::....|||:..  |:|.::.::..:.|:
Mouse    25 FSAYSPI------GHAKYSSLPEVVTPLRVTVTRGNNSSPGWLSYSLSIGGQRHIITMKPKENLI 83

  Fly   105 PNSHFLRYQNASRG-ATPGHVVTTFTKTEVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQ 168
             :.:||.:..:.:| ....|   .|.:.:   |:|.|::...|||:|.::||.|:|.|.:.....
Mouse    84 -SRNFLLFTYSDQGDLLEEH---PFVQND---CYYHGYVDEDPESLVIVNTCFGSLQGTLEINGT 141

  Fly   169 TYFIHPHIDGRGRLQD-DH--YLLKQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSL 230
            .|.|.|    |.:... :|  |.:...:..|:...||
Mouse   142 IYEIMP----RSKTSTFEHLAYKMDSGESEPSPMRCG---------------------------- 174

  Fly   231 PLRLDGGEFSRTLLRKRRQADDSSQLIRGPY-NANKYSSYVELVIVVDNKVYKNFQENTKKVHQY 294
               |...|.::.:   ..|..::|.|::.|| |...:..:::..:|:|:..|.:...||....|.
Mouse   175 ---LSEEEIAQQM---NLQESNASTLLQIPYENWWTHHRFIDYFVVIDHNCYVHRNNNTTTCIQD 233

  Fly   295 CKGIANIINALYVPLNIFVALVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQL 359
            ...:.|.||..::.:...|.|..|.:|:::|.|....:....|..|.:::...:.....:|...|
Mouse   234 MLQVVNGINGYFLQIQTDVVLTKVEVWSQNNLINVEEEMSAALDAFCSWKKNAIGNRVRHDIIHL 298

  Fly   360 LTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSDCHCRDE 424
            ..:.|:. ..:|.|..|.:| ...:..|:...:.:.:.:|..:|||||||.||:||.|.|.|...
Mouse   299 FVRHNYV-KFLGMAKLGQVC-LTLNCAVNSFLTDSLSYLAFIVAHEMGHNLGMKHDGSACTCGLH 361

  Fly   425 KCVMAASSTSFIPVNWSSCSIDQLTIAFSRGMNYCLRNKPERLFE---SPT-CGNGFVEPGEQCD 485
            .|:|  ...::|...:|:||.:::....:|  ..||.|.|:.|..   .|| |||..||.|||||
Mouse   362 TCIM--YPYAYISPKFSNCSYEEMFSVVNR--RSCLYNIPDALKTITLVPTMCGNNLVEEGEQCD 422

  Fly   486 CGLPEHC-ENACCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESE 549
            ||..|.| ::.||::. |:| ...|.||.|.||  ..|:....|:.||:.:|||||||:|.|.|.
Mouse   423 CGNSESCLQDPCCSSD-CVL-KPGAKCAFGLCC--KDCQFLQTGTVCRQEKNECDLPEWCNGTSG 483

  Fly   550 YCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWGPTGDNS-EHCY-NKNTEGTRLGNCGYN 612
            .||.||::.|...|..| .||:...|:.|..|||.::|....:: |.|| ..|..|.|.||||.:
Mouse   484 ECPGDVYKADGIRCSRG-GYCYKMECQRHDRQCREIFGKRSRSADEICYMEMNRRGDRFGNCGND 547

  Fly   613 RLNKTFLRCEEQHVNCGMLHC---IHLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQ 674
              :..:.|||...|.||.:.|   |.|.:|     .:...:.:::.|::    .|.|.....|:.
Mouse   548 --SSMYKRCELTDVLCGRIQCENVIKLPQR-----RNHETVHYTHFSNN----TCWTMDYHFGIT 601

  Fly   675 TTDPGLTPNGAKCGVDKMCVDQRCLPVDAVRQKGMGKPC-PEDCNGNGICNSRGHCHCDVGFGGE 738
            ..|.|...:|..|..|.:|:|::|     |.:..:...| |..|:..|:||::.||||...:...
Mouse   602 IDDVGAVSDGTPCAPDHICLDRKC-----VSKSVLVSNCTPHLCHMQGVCNNKHHCHCTNTWEPP 661

  Fly   739 SCSKAGSGGSPDSGPATDP----NGSVGFKRF--LYVLFFFVLPVVALFWFLYHCYKNGMLTRGK 797
            .|...|.|||.||||...|    |.|:.|..|  :|||.|..|            |....|.:..
Mouse   662 DCQLHGHGGSIDSGPPPVPLSPSNWSMYFLAFIIMYVLGFIAL------------YGIRELRKKL 714

  Fly   798 LADNILKSSGGSKPITTR 815
            |.:::.:|..|.|.:|.:
Mouse   715 LKESVPESDSGDKNLTRK 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	30/118 (25%)
		Reprolysin	269..464	CDD:279729	50/194 (26%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	49/192 (26%)
		Disintegrin	479..555	CDD:278623	36/76 (47%)
		ACR	558..701	CDD:214743	43/147 (29%)
Adam34l	NP_001020411.1	Pep_M12B_propep	41..159	CDD:366707	30/128 (23%)
		ZnMc_adamalysin_II_like	207..395	CDD:239797	49/193 (25%)
		Disintegrin	416..488	CDD:365943	36/75 (48%)
		ACR	492..628	CDD:214743	44/152 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0000154
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920