DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and Adam20

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001009548.1	Gene:	Adam20 / 384806	MGIID:	2152342	Length:	760	Species:	Mus musculus

Alignment Length:	722	Identity:	221/722 - (30%)
Similarity:	345/722 - (47%)	Gaps:	99/722 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 VTTFTK----------TEVDLCHYQGHIRGKPESVVALSTCDGALDGIV-IDGRQTYFIHPHIDG 178
            |.|:||          .:.| |:|.||:.|.|||:||::||.|...||: |:|  |.:
Mouse   104 VFTYTKQGALHKDQPYVQND-CYYHGHMDGDPESMVAITTCYGGFQGILQING--TVY------- 158

  Fly   179 RGRLQDDHYLLKQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTL 243
                          ::.|.|.:..::       |...|.|.:.     ...||:|....|  ...
Mouse   159 --------------EIKPKNLSSTFE-------HLVHKMDSEE-----TELLPMRCALTE--EIA 195

  Fly   244 LRKRRQADDSSQLIRGPYNA-NKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYV 307
            .:.:||.:::..|::..|.. ..:.|:::|.:|||.:..:....|...|......|.::||.:|.
Mouse   196 KQMKRQQNENPTLMQNHYEEWWTHRSFLDLALVVDCERIRYHNNNKSHVLVEVFLIISLINKIYF 260

  Fly   308 PLNIFVALVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGK 372
            .|:|.|.|:|:.:|||.|.:.... ..:.|..|..:::..|.:..|||.|.|....:| |..:|.
Mouse   261 ALDIEVVLIGLELWNEGNLVPVDR-MQILLEEFCVWKTLSLNIRIPNDIAHLFVNHSF-GKFLGL 323

  Fly   373 ALKGPICTYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSDCHCRDEKCVMAASSTSFIP 437
            |..|.:|...::.||.....||....|..:|||:|||.|||||:|.|.|......:.:|:.||.|
Mouse   324 AYVGTVCLPSHNCGVDRLLGPNLFQFAHIIAHEIGHNLGMEHDSSSCTCGGINYCLMSSTYSFNP 388

  Fly   438 VNWSSCSIDQLTIAFSRGMNYCLRNKPERL--FESPTCGNGFVEPGEQCDCGLPEHCE-NACCNA 499
             .:|:||.......::  ...|||.:...:  .:...||||.|:.|||||||....|| :.|||:
Mouse   389 -EFSNCSYSNFWTTYA--TTNCLRKEKMSIGNLQIQFCGNGVVDDGEQCDCGDRHMCERDQCCNS 450

  Fly   500 QTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPC- 563
            : |.|:. .|.||.|.||  ..|:...||:.|||..|||||||:|.|.|..||.||:..|..||
Mouse   451 R-CALND-GAACAFGLCC--LYCQIMPAGTVCREEVNECDLPEWCNGHSHKCPNDVYLLDGSPCR 511

  Fly   564 DGGQAYCFHGTCRSHSNQCRTLWGPTGDNSEH-CYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHV 626
            |||  ||:...|.:...||:.::|....:::| ||.: ||:|.|.||||  .:...:|||.:..:
Mouse   512 DGG--YCYEKRCNNRDEQCKQIFGKEARSADHSCYRELNTQGDRFGNCG--MIRDAYLRCHDSDI 572

  Fly   627 NCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKI--VACRTALVDLGLQTTDPGLTPNGAKCGV 689
            .||.:.|.::. |:.|      :..||.: |...:  |.|.......|:...|.|:..:|..||.
Mouse   573 LCGRVQCENVT-RIPF------LRDHSTV-HWTHLNGVTCWGTDYHFGMTIPDIGIVKDGTDCGP 629

  Fly   690 DKMCVDQRCLPVDAVRQKGMGKP-----C-PEDCNGNGICNSRGHCHCDVGFGGESCSKAGSGGS 748
            :.:|::::|          :.||     | .:.|...|:||:..||||:.|:....|.::|.|||
Mouse   630 EHVCINKKC----------VSKPIWLEQCSSKTCTMKGVCNNLHHCHCNRGWDPPHCLESGFGGS 684

  Fly   749 PDSGPATDPNGSVGFKRFL-YVLFFFVLPVVALFWFLYHCYKNGMLTRGKLADNILKSSGGSKPI 812
            .||||   |.|....::.: .||...:|.:|:|.:.|.......:.|..|..:..:.:|...:..
Mouse   685 VDSGP---PPGEEESQQHMDLVLITPILSIVSLVFLLPWLLNRYIRTSSKFEEPTVSTSKEEEES 746

  Fly   813 TTRTNQN 819
            ...:|::
Mouse   747 HVASNES 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	23/59 (39%)
		Reprolysin	269..464	CDD:279729	62/194 (32%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	61/192 (32%)
		Disintegrin	479..555	CDD:278623	38/76 (50%)
		ACR	558..701	CDD:214743	44/147 (30%)
Adam20	NP_001009548.1	Pep_M12B_propep	57..173	CDD:366707	26/99 (26%)
		ZnMc_adamalysin_II_like	222..408	CDD:239797	59/190 (31%)
		Disintegrin	429..501	CDD:365943	38/75 (51%)
		ACR	505..641	CDD:214743	44/157 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0000154
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920