Protein Alignment Meltrin and Adam20

DIOPT Version :10

• Sequence 1: NP_001027575.1
• Gene: Meltrin / 3772109
• FlyBaseID: FBgn0265140
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: NP_001009548.1
• Gene: Adam20 / 384806
• MGIID: 2152342
• Length: 760
• Species: Mus musculus
• Alignment Length: 722
• Identity: 221/722 - (30%)
• Similarity: 345/722 - (47%)
• Gaps: 99/722 - (13%)

  Fly   125 VTTFTK----------TEVDLCHYQGHIRGKPESVVALSTCDGALDGIV-IDGRQTYFIHPHIDG 178
            |.|:||          .:.| |:|.||:.|.|||:||::||.|...||: |:|  |.:
Mouse   104 VFTYTKQGALHKDQPYVQND-CYYHGHMDGDPESMVAITTCYGGFQGILQING--TVY------- 158

  Fly   179 RGRLQDDHYLLKQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTL 243
                          ::.|.|.:..::       |...|.|.:.     ...||:|....|  ...
Mouse   159 --------------EIKPKNLSSTFE-------HLVHKMDSEE-----TELLPMRCALTE--EIA 195

  Fly   244 LRKRRQADDSSQLIRGPYNA-NKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYV 307
            .:.:||.:::..|::..|.. ..:.|:::|.:|||.:..:....|...|......|.::||.:|.
Mouse   196 KQMKRQQNENPTLMQNHYEEWWTHRSFLDLALVVDCERIRYHNNNKSHVLVEVFLIISLINKIYF 260

  Fly   308 PLNIFVALVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGK 372
            .|:|.|.|:|:.:|||.|.:.... ..:.|..|..:::..|.:..|||.|.|....:| |..:|.
Mouse   261 ALDIEVVLIGLELWNEGNLVPVDR-MQILLEEFCVWKTLSLNIRIPNDIAHLFVNHSF-GKFLGL 323

  Fly   373 ALKGPICTYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSDCHCRDEKCVMAASSTSFIP 437
            |..|.:|...::.||.....||....|..:|||:|||.|||||:|.|.|......:.:|:.||.|
Mouse   324 AYVGTVCLPSHNCGVDRLLGPNLFQFAHIIAHEIGHNLGMEHDSSSCTCGGINYCLMSSTYSFNP 388

  Fly   438 VNWSSCSIDQLTIAFSRGMNYCLRNKPERL--FESPTCGNGFVEPGEQCDCGLPEHCE-NACCNA 499
             .:|:||.......::  ...|||.:...:  .:...||||.|:.|||||||....|| :.|||:
Mouse   389 -EFSNCSYSNFWTTYA--TTNCLRKEKMSIGNLQIQFCGNGVVDDGEQCDCGDRHMCERDQCCNS 450

  Fly   500 QTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPC- 563
            : |.|:. .|.||.|.||  ..|:...||:.|||..|||||||:|.|.|..||.||:..|..||
Mouse   451 R-CALND-GAACAFGLCC--LYCQIMPAGTVCREEVNECDLPEWCNGHSHKCPNDVYLLDGSPCR 511

  Fly   564 DGGQAYCFHGTCRSHSNQCRTLWGPTGDNSEH-CYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHV 626
            |||  ||:...|.:...||:.::|....:::| ||.: ||:|.|.||||  .:...:|||.:..:
Mouse   512 DGG--YCYEKRCNNRDEQCKQIFGKEARSADHSCYRELNTQGDRFGNCG--MIRDAYLRCHDSDI 572

  Fly   627 NCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKI--VACRTALVDLGLQTTDPGLTPNGAKCGV 689
            .||.:.|.::. |:.|      :..||.: |...:  |.|.......|:...|.|:..:|..||.
Mouse   573 LCGRVQCENVT-RIPF------LRDHSTV-HWTHLNGVTCWGTDYHFGMTIPDIGIVKDGTDCGP 629

  Fly   690 DKMCVDQRCLPVDAVRQKGMGKP-----C-PEDCNGNGICNSRGHCHCDVGFGGESCSKAGSGGS 748
            :.:|::::|          :.||     | .:.|...|:||:..||||:.|:....|.::|.|||
Mouse   630 EHVCINKKC----------VSKPIWLEQCSSKTCTMKGVCNNLHHCHCNRGWDPPHCLESGFGGS 684

  Fly   749 PDSGPATDPNGSVGFKRFL-YVLFFFVLPVVALFWFLYHCYKNGMLTRGKLADNILKSSGGSKPI 812
            .||||   |.|....::.: .||...:|.:|:|.:.|.......:.|..|..:..:.:|...:..
Mouse   685 VDSGP---PPGEEESQQHMDLVLITPILSIVSLVFLLPWLLNRYIRTSSKFEEPTVSTSKEEEES 746

  Fly   813 TTRTNQN 819
            ...:|::
Mouse   747 HVASNES 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	53..174	CDD:460254	23/59 (39%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	61/192 (32%)
		Disintegrin	479..554	CDD:459709	38/75 (51%)
		ACR	558..701	CDD:214743	44/147 (30%)
		PHA03247	<823..1261	CDD:223021
		PHA03247	<1220..1392	CDD:223021
Adam20	NP_001009548.1	Pep_M12B_propep	57..173	CDD:460254	26/99 (26%)
		ZnMc_adamalysin_II_like	222..408	CDD:239797	59/190 (31%)
		Disintegrin	429..501	CDD:459709	38/75 (51%)
		ACR	505..641	CDD:214743	44/157 (28%)