DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meltrin and adam8a

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_956931.1	Gene:	adam8a / 368917	ZFINID:	ZDB-GENE-030616-622	Length:	843	Species:	Danio rerio

Alignment Length:	1018	Identity:	293/1018 - (28%)
Similarity:	414/1018 - (40%)	Gaps:	252/1018 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 YTVIRPQVEHGRTKRSLLTTLDATDGLHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNA 115
            |.|:|.|...|||:|| .::|..    :..|:......:|:.:.:.|.||..||...:.|.:...
Zfish    29 YDVVRLQALRGRTRRS-ASSLQK----YPEQLEYDVAIDGRNLTISLHRNRELLGKQYTLTHYGE 88

  Fly   116 SRGATPGHVVTTFTKTEVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHP---HID 177
            .      .:..|.:..:.:.|:|.|||....:|.|::..|.| ::|.:....|.|.|.|   .:|
Zfish    89 D------GISETKSSNKFNHCYYHGHIHNFEDSSVSVGLCSG-MEGFLRVNDQVYLIEPLEESLD 146

  Fly   178 GRGRLQDDHYLLKQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRT 242
            |      ||.:.||..:.......||.|   |..:|         ||
Zfish   147 G------DHAIYKQEHLRTKRGAYGYIN---DTVYD---------LG------------------ 175

  Fly   243 LLRKRRQADDSSQLIRGPYNANKY----SSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIIN 303
                    ..||.|.:|....||.    ...||:|:||||..||.| .:.||:.:....:||.::
Zfish   176 --------PKSSGLYKGKNMRNKAPRGGQQIVEMVLVVDNTEYKKF-GSFKKIEERMMLVANHVD 231

  Fly   304 ALYVPLNIFVALVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGG 368
            .||.||||.|.|||:.:|::.:.|:.||..:|||..||.:|...|:....:|||..:|..:|.|.
Zfish   232 KLYRPLNIRVMLVGLEVWSQRDLIDVSSRPNLTLERFLKWRRDSLLQRKKHDNAHFITGIDFEGS 296

  Fly   369 VVGKALKGPICTYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSDCHCRDEK-CVMAASS 432
            .||.|....:|:...||.|:..|:.||..||:|:|||||||.||.||.|.|.|...| |:|..:.
Zfish   297 TVGLATLYAMCSSSSSGAVNEDHNSNPIAVASTVAHEMGHNLGMSHDDSSCGCSSNKGCIMGDTI 361

  Fly   433 TSFIPVNWSSCSIDQLTIAFSRGMNY---CLRNKPE--RLFESPTCGNGFVEPGEQCDCGLPEHC 492
            .|..|.::|:||...|. ||..  ||   ||.:.|.  :::..|.|||.|||.||:||||..|.|
Zfish   362 GSIYPDSFSTCSQSSLK-AFLE--NYDTNCLIDVPNEGQIYGGPVCGNAFVEKGEECDCGTVEEC 423

  Fly   493 ENACCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFR 557
            .|.||||.||.| ::.|.||.||||.  .|:.|..||.||::.::|||.|||||||.:||.|.::
Zfish   424 NNPCCNATTCRL-TEGARCAHGECCH--NCQLKHTGSLCRKSAHDCDLDEYCTGESAFCPEDDYK 485

  Fly   558 RDTEPCDGGQAYCFHGTCRSHSNQCRTLWGPTGD-NSEHCYNKNTEGTRLGNCGYNRLNKTFLRC 621
            .:..||:..|.||::|.|.:|...|:.|||...| :.:.|:.            ||.:::|....
Zfish   486 MNGLPCNYNQGYCYNGQCPTHKEHCKMLWGSGADVDDDACFQ------------YNVIDRTSKSA 538

  Fly   622 EEQHVNCGMLHCI------HLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDL-GLQTTDPG 679
            |  |..||.::|.      ..|::....::|                  ||..:.| ...|.|.|
Zfish   539 E--HRKCGRIYCYGGNPFPKTNKKANVNVQS------------------RTCYMALDSSPTEDLG 583

  Fly   680 LTPNGAKCGVDKMCVDQRCLPVDAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGFGGESCSKAG 744
            :.|.|.|||.:|:|....||.:.....:.    |...||..|:||....||||.|:....|
Zfish   584 MVPTGTKCGTNKVCYKSLCLDISMYGTEN----CSNKCNNRGVCNHELKCHCDPGWAPPYC---- 640

  Fly   745 SGGSPDSGPATDPNGS----------VGFKRFLYVLFFFVLPVVALFWFLYHCYKNGMLTRGKLA 799
                       |...|          :|....|.:|...:: :.||.:           .|.|:.
Zfish   641 -----------DIQLSELHKMRKSVVIGVTTSLAILVLIII-IGALVY-----------NRNKIT 682

  Fly   800 DNILKSSGGSKPITTRTNQNGTGPPPSNGLLKSTPSSTDDMDSALLKSPSDSTPSAGLFGKFDGF 864
            :...|.                   |..|:..|:..
Zfish   683 EFRKKR-------------------PQKGIHSSSGQ----------------------------- 699

  Fly   865 TLRPLNDASSPASNYNGPNVA---FVQPTVQQDGPQRMAPPPPVVKPGTAPIHP-PSPKPEATWV 925
                .|.|..|.|..|.|.:|   ..|||..:....:...|   ::....|..| |.|...|...
Zfish   700 ----CNPAFQPGSAKNSPRIAQPRISQPTFLESSATQACKP---LRSAAMPCRPAPMPPKNAPQT 757

  Fly   926 RPAPALPPPNPGSTARPIISPPKLDSSTLTMVPLKDSTEDLSPSRSAPPVPLHADPKLNVKRDGT 990
            |....:.||.|.|.....|.||:..       ||..:.:.|.|||..||:...|..|
Zfish   758 RNEQIMKPPVPPSAISKNIYPPQAK-------PLLPAAKPLPPSRPLPPLASKAVTK-------- 807

  Fly   991 IRRFASFLKKEEKPPLKEKTYIDRERLRTLEISAPMPVPAAPQ 1033
                   .|....||:|.              |.|.||...||
Zfish   808 -------SKSPPVPPVKP--------------SGPQPVFTPPQ 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	25/109 (23%)
		Reprolysin	269..464	CDD:279729	83/198 (42%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	83/196 (42%)
		Disintegrin	479..555	CDD:278623	42/75 (56%)
		ACR	558..701	CDD:214743	39/150 (26%)
adam8a	NP_956931.1	Pep_M12B_propep	42..157	CDD:279848	32/132 (24%)
		Reprolysin	199..393	CDD:279729	83/197 (42%)
		ZnMc_adamalysin_II_like	199..389	CDD:239797	81/193 (42%)
		Disintegrin	410..482	CDD:278623	42/74 (57%)
		ACR	486..605	CDD:214743	39/150 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	153	1.000	Domainoid score	I4239
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0000154
OrthoInspector	1	1.000	-	-		otm24708
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.920