DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and Adam34l

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_006253241.1	Gene:	Adam34l / 364599	RGDID:	1307052	Length:	792	Species:	Rattus norvegicus

Alignment Length:	736	Identity:	205/736 - (27%)
Similarity:	336/736 - (45%)	Gaps:	105/736 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 HTPQISLSYTHE--GKRVVVDLQRNDLLLPNSHFLRYQNASRG----ATPGHVVTTFTKTEVDLC 136
            ||....|||:.:  |::.::.::....|: :.:||.:..:.:|    ..|      |.:.:   |
  Rat    42 HTSTGWLSYSLQFGGEKCIITMKPKKNLI-SRNFLLFTYSEQGDLLEEQP------FVQND---C 96

  Fly   137 HYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTNATC 201
            :|..::...|||.|.::.|.|:|.||:.....||                      ::.|.::|.
  Rat    97 YYHDYVDEDPESFVIVNNCFGSLQGILEINDTTY----------------------EIMPKSSTS 139

  Fly   202 GYDNHRDDHSHDYEKADGDNGLGGGIPSLPLR--LDGGEFSRTLLRKRRQADDSSQLIRGPYNA- 263
            .:|:..      |....|.:.|      .|:|  |...|.:|.:  |||.::||:.: :.||.:
  Rat   140 TFDHLA------YRMNSGASEL------FPMRWGLSEEEIARQM--KRRVSNDSTPM-KIPYESW 189

  Fly   264 NKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNESNEIE 328
            ..:..::|..:::||..|.:...||....|....:.|.|:..|:.::..|.|..:.:|||.|.:.
  Rat   190 WTHHKFIEYFVIIDNNQYVHRSSNTTACIQDMLQMINGISGYYLQIDTDVVLKTLEVWNEKNHVN 254

  Fly   329 FSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSP 393
            ...:....|.:|..::.|.:.....:|...|..:..: |..:..|..|.:|| ..:..|:...|.
  Rat   255 VEQNIHNVLNDFCTWKQTSIGNRVRHDIIHLFVRHRY-GIYLALAHVGTVCT-PNNCSVNSIISD 317

  Fly   394 NPAMVATTMAHEMGHNFGMEHDTSDCHCRDEKCVMA---ASSTSFIPVNWSSCSIDQLTIAFSRG 455
            :.:.:|..:|||||||.||.||.|.|.|..:.|:||   ::|..|     |:||.:::....:|
  Rat   318 SMSDMAFIIAHEMGHNLGMLHDVSGCTCGRKSCIMAPYKSNSAKF-----SNCSYEEMYSVVTR- 376

  Fly   456 MNYCLRNKPERLFES--PTCGNGFVEPGEQCDCGLPEHCENACCNAQTCMLHSKNATCATGECCD 518
            .:| |.|.|:.|..:  ..|||..||.|||||||..|.|....|.::.|:| ...|.||.|.||.
  Rat   377 RSY-LYNTPDTLVTTHMTVCGNNLVEEGEQCDCGNLESCSKDPCYSEDCVL-KPGAQCAFGLCCQ 439

  Fly   519 LTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQCR 583
            .....|  .|:.||:.:||.||||:|.|.|..||.||:..|..||.|| .||:.........||:
  Rat   440 DFQFLP--TGTMCRKEKNESDLPEWCNGSSHECPGDVYLLDGSPCSGG-GYCYKMAWHEREAQCK 501

  Fly   584 TLWG-PTGDNSEHCY-NKNTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERLEFGMES 646
            .::| .:...:|.|| ..|.:|.|..|||.:  ::.::.|....|.||.:.|.:        :|.
  Rat   502 KIFGMESRSANEICYMEMNKQGDRFDNCGNH--SENYIGCNITDVFCGRIQCDN--------VEQ 556

  Fly   647 AAVLSHSYISHDRKI--VACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPVDAVRQKGM 709
            ..:..:....|..:.  ..|.|.....|..|.|.....:|..||.:.:|:|::|     |.:..:
  Rat   557 IPLRKNHETLHWTQFNNFTCWTMDYHFGSTTEDSRAVEDGTACGPNHICIDRKC-----VSKSIL 616

  Fly   710 GKPCPED-CNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSGPA----TDPNGSVGFKR---- 765
            ...|.|. |:..|:||::.||||:|.:....|...|...|.||||:    |:...:|..|.
  Rat   617 FGNCSESFCSMQGVCNNKDHCHCNVPWEPPDCQLPGFRDSIDSGPSLGTLTNQRETVKGKSLVGF 681

  Fly   766 ---FLYVLFFFVLPVVALFWF 783
               |:..|||.:|.::.|.::
  Rat   682 IIPFMISLFFLILLILQLAFY 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	25/101 (25%)
		Reprolysin	269..464	CDD:279729	55/197 (28%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	54/195 (28%)
		Disintegrin	479..555	CDD:278623	34/75 (45%)
		ACR	558..701	CDD:214743	37/146 (25%)
Adam34l	XP_006253241.1	Pep_M12B_propep	46..143	CDD:279848	25/128 (20%)
		ZnMc_adamalysin_II_like	194..377	CDD:239797	52/190 (27%)
		Reprolysin	194..376	CDD:279729	51/188 (27%)
		Disintegrin	401..474	CDD:278623	34/75 (45%)
		ACR	477..613	CDD:214743	38/151 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0000154
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020