DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and Adam32

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001164053.1	Gene:	Adam32 / 361170	RGDID:	735114	Length:	752	Species:	Rattus norvegicus

Alignment Length:	882	Identity:	231/882 - (26%)
Similarity:	366/882 - (41%)	Gaps:	189/882 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLHLHLFLLPLLLLNTCLQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRTKR 65
            |||..|.||                ||..|...| |..|::       |...:|.|:....:|..
  Rat     5 MLHTLLLLL----------------AELGALLAS-GPDSQS-------SFLEIIFPEKIEDKTNS 45

  Fly    66 SLLTTLDATDGLHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTK 130
            .             .|||.......|:..|.||:...|  .:.|:.|. .::|:      |:|..
  Rat    46 E-------------EQISYVIPINKKKYTVHLQKRYFL--TNRFMVYM-YNQGS------TSFHS 88

  Fly   131 TEVDL-CHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDH--YLLKQA 192
            :.:.. |:|||:|:|.|.||..||||.|.                    ||.||.::  |.::..
  Rat    89 SNIPAQCYYQGYIKGYPGSVATLSTCSGL--------------------RGFLQFENVSYGIEPL 133

  Fly   193 DMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTL--------LRKRRQ 249
            :...|:....|:                  ||.|...|....:    ||.|        |..::.
  Rat   134 ESAATSQHIVYE------------------LGKGEKELLFNKN----SRNLEMPTNYGILINKKP 176

  Fly   250 ADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVA 314
            ...|..|         :|.|:|:.||||..:|.....::..|......|.:::|:::....:.:.
  Rat   177 KSPSKHL---------FSLYLEMTIVVDKALYDYLGSDSMIVTNKVIEIISLVNSVFEQFKVTIV 232

  Fly   315 LVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPIC 379
            |..:.:|::.|:|....:.|..||.|..::.:.|.| .|:|.|.|.. .|.....:|....|.:|
  Rat   233 LSSLELWSDKNKIPTVGEADELLRRFSEWKQSYLTL-RPHDVAYLFI-YNEQPNYMGATYPGKMC 295

  Fly   380 TYEYSGGVSMQHSPNP------AMVATTMAHEMGHNFGMEHDTSD-CHCRDEKCVMAASSTSFIP 437
            |..||.|::|.  |..      :::.|.|   :|.:.|:.:|..: |||.::.|:|...:..:..
  Rat   296 TAPYSAGITMY--PKDMTLEAFSVILTQM---LGLSLGISYDNPEKCHCSEKVCIMNPRAMQYTG 355

  Fly   438 V-NWSSCSIDQL-TIAFSRGMNYCLRNKPERLFESP--TCGNGFVEPGEQCDCGLPEHC-ENACC 497
            | .:|:||.:.. ....:.|.. ||:|||| :..||  .||||.||..|.||||..:.| .|:||
  Rat   356 VKTFSNCSSNDFERFKLNEGAK-CLQNKPE-MQRSPRAVCGNGKVEGDEICDCGSQQQCGANSCC 418

  Fly   498 NAQTCMLHSKNATC----ATGECC-------DLTTCRPKLAGSACREAENECDLPEYCTGESEYC 551
            ...:|:|.|..| |    .:..||       |...|||        .:...||:.|.|.|.|..|
  Rat   419 EPTSCVLKSGKA-CDSMSPSATCCKDCQFLPDKHECRP--------SSNMYCDIAEVCNGSSGQC 474

  Fly   552 PADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWGPTGDNSEH-CYNK-NTEGTRLGNCGYNRL 614
            |.|:...:...|..|...|::|.|.:....|..::|....|:.. ||.: ..:..|.||||.::.
  Rat   475 PPDIILSNGIICGEGGTVCYNGNCPNLDRACEAMYGLGSTNAPFACYEEIQGQNDRFGNCGKDQQ 539

  Fly   615 NKTFLRCEEQHVNCGMLHCIHLNERLEF---GMESAAVLSHSYISHDRKIVACRTALVDLGLQT- 675
            |: ::.|..:::.||.|.|.: ..:|.|   .:.:|:|: :::: .|:..::     ||.|...
  Rat   540 NR-YIFCGWRNLICGRLVCTY-PSKLPFIPPNISTASVI-YAFV-RDKVCIS-----VDFGSSVK 595

  Fly   676 TDPGLTPNGAKCGVDKMCVDQRCLPVDAVRQKGMGKPCPE-DCNGNGICNSRGHCHCDVGFGGES 739
            .||....|||.|.:|::|::..|  |::...|.....|.| .|||:|:|.|||.|||..||...|
  Rat   596 EDPLRVLNGAVCDLDRICLNGVC--VESRFLKAQSTSCAEAKCNGHGVCTSRGDCHCSEGFQPPS 658

  Fly   740 CSKAGSG--------GSPDSGPATDPNGSVGFKRFLYVLFFFVLPVVAL--FW-FLYHC---YKN 790
            |:....|        |.|..|.:.  |....:...||::...:...|.|  .| .|..|   .:.
  Rat   659 CTPKEGGDSSWYGRQGLPMEGASR--NREKKWLLSLYIVLIILTTAVVLGTGWKGLKKCRFKEEE 721

  Fly   791 GMLTRGKLADNILKSSGGSKPITTRTNQNGTGPPPSN 827
            .|.:..|..||....:..||      ::..:|.|.|:
  Rat   722 SMSSESKSEDNTQTYNSRSK------SEASSGSPTSS 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	27/110 (25%)
		Reprolysin	269..464	CDD:279729	52/203 (26%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	51/201 (25%)
		Disintegrin	479..555	CDD:278623	29/87 (33%)
		ACR	558..701	CDD:214743	38/148 (26%)
Adam32	NP_001164053.1	Pep_M12B_propep	46..143	CDD:279848	33/138 (24%)
		Reprolysin	187..383	CDD:279729	52/203 (26%)
		ZnMc_adamalysin_II_like	187..381	CDD:239797	51/201 (25%)
		Disintegrin	399..478	CDD:278623	29/87 (33%)
		ACR	482..621	CDD:214743	39/149 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920