DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meltrin and Adam11

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_017452891.1	Gene:	Adam11 / 360638	RGDID:	1307515	Length:	833	Species:	Rattus norvegicus

Alignment Length:	957	Identity:	268/957 - (28%)
Similarity:	401/957 - (41%)	Gaps:	179/957 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LFLLPLL------LLNTCLQQHILQPAEATAFHQSEG-EKSKAHPVLEEFSTYTVIRPQVEHGRT 63
            |.|||||      .|......|....|...:....|| |.::...::.|.|...|.:||:: .|.
  Rat    12 LLLLPLLPPPGLGALGPSGALHWRSSAHMGSPESPEGPEVTEPSRLVRESSGGEVRKPQLD-TRV 75

  Fly    64 KRSLLTTLDATDG--LHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVT 126
            ::      |...|  :|..|:|...........:||:.|..||.:.:..|:  .||..|..|
  Rat    76 RQ------DPPRGTPVHLAQVSFVIPAFDSNFTLDLELNHHLLSSQYVERH--FSREGTRQH--- 129

  Fly   127 TFTKTEVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHP-HIDG-----RGRLQDD 185
              :....|.|:|.|.:|..|.|..|||||.| |.|:..||..||.:.| .:.|     :|.|.
  Rat   130 --STGAGDHCYYHGKLRDNPHSFAALSTCQG-LHGVFSDGNLTYIVEPKEMAGPWGPPQGPLP-- 189

  Fly   186 HYLLKQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQA 250
             :|:.:..:.|....|                 .:.|....:|:     .....||..||::|
  Rat   190 -HLIYRTPLLPAPFGC-----------------REPGCLFAVPA-----QSAAPSRPKLRRKR-- 229

  Fly   251 DDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALY-VPLNIFVA 314
                |:.||....:..:.||||:::.|:::::..:::......:.|.:.|:.:.:| ..||..:.
  Rat   230 ----QVRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIV 290

  Fly   315 LVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPIC 379
            ||.:..|.:.::|:...|...||...:.||  :..|..|:|...|.:...|.....|.|..|.||
  Rat   291 LVAMETWADGDKIQVQDDLLETLARLMVYR--REGLPEPSDATHLFSGRTFQSTSSGAAYVGGIC 353

  Fly   380 TYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGM---EHDTS--DCHCRD--EKCVMAASSTSF-I 436
            :....|||:  ...|...:|.|:|..:|.|.||   :|.:|  ||.|.|  ..|:|  ..|.| :
  Rat   354 SLSRGGGVN--EYGNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIM--EDTGFYL 414

  Fly   437 PVNWSSCSIDQLTIAFSRGMNYCLRNKPERLFESPTCGNGFVEPGEQCDCGLPEHCENA---CCN 498
            |..:|.||||:.......|...||.|||.:|.:.|.|||||||.||:||||..:.|..|   ||
  Rat   415 PRKFSRCSIDEYNQFLQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCC- 478

  Fly   499 AQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPC 563
             :.|.| :.:|.|:.|.||  ..|:.:..|.:||||.||||:.|.|||:|..||.::.:.|...|
  Rat   479 -KKCTL-THDAMCSDGLCC--RRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYC 539

  Fly   564 DGGQAYCFHGTCRSHSNQCRTLWGPTGDNSEHCYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVN 627
            |..|..|:.|.|::...||:.|||....: ..||.| |.|||..||||  |....:::|.:|.|.
  Rat   540 DHEQGRCYGGRCKTRDRQCQALWGHVAAD-RFCYEKLNVEGTERGNCG--RKGSGWVQCNKQDVL 601

  Fly   628 CGMLHCIHLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPGLTPNGAKCGVDKM 692
            ||.|.|::::.....|.....:.|.::. |..|.:.||...|.|. ..:|.....:|..||.:.:
  Rat   602 CGFLLCVNISGAPRLGDLGGDISSVTFY-HQGKELDCRGGHVQLA-DGSDLSYVEDGTACGPNML 664

  Fly   693 CVDQRCLPVDAVRQKGMGKPCPED-----CNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSG 752
            |:|.||||..|..    ...||..     |:.:|:|::.|.|.|...:.|:.||      ..:..
  Rat   665 CLDHRCLPASAFN----FSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCS------IHNPL 719

  Fly   753 PATDPNGSVGFKRFLYVLFFFVLPVVALFWFLYHCYKNGMLTRGKLADNILKSSGGSKPITTRTN 817
            |.:.|.|..                        ..||...:..|.           ::|...:.:
  Rat   720 PTSPPTGET------------------------ERYKETSVAEGM-----------TRPSRGQCD 749

  Fly   818 QNGTGPPPSNGLLKSTPSSTDDMDSALLKSPSDSTPSAGLFGKFDGFTLRPLNDASSPASNYNGP 882
            .....||.....:.|.|..:.|.:...::|.|    .||..||.....|||
  Rat   750 AGHVIPPAVLVSISSVPLHSVDRELGPIRSRS----PAGSLGKRIRCLLRP-------------- 796

  Fly   883 NVAFVQPTVQQDGPQRMAPPPPV-----------VKPGTAPIHPPSP 918
               |:.||      :.:.|..|.           |..||.| ..|||
  Rat   797 ---FLLPT------RLLGPGSPSSVLSAAGSHGRVGAGTVP-RNPSP 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	34/111 (31%)
		Reprolysin	269..464	CDD:279729	60/203 (30%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	59/201 (29%)
		Disintegrin	479..555	CDD:278623	35/78 (45%)
		ACR	558..701	CDD:214743	48/143 (34%)
Adam11	XP_017452891.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	73	1.000	Domainoid score	I9011
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920