DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and Adam32

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_700446.2	Gene:	Adam32 / 353188	MGIID:	2653822	Length:	754	Species:	Mus musculus

Alignment Length:	869	Identity:	219/869 - (25%)
Similarity:	354/869 - (40%)	Gaps:	190/869 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLHLHLFLLPLLLLNTCLQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRTKR 65
            ||...|..|.||||           ||..|...| |.:|::       |...:|.|:....:|
Mouse     1 MLGAMLHTLLLLLL-----------AELGALLAS-GPESQS-------SFLEIIFPEKIEDKT-- 44

  Fly    66 SLLTTLDATDGLHT-PQISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFT 129
                        |: .|||.......|:..|.||:...|  .:.|:.|. .::|:|..|......
Mouse    45 ------------HSEEQISYIIPINKKQYTVHLQKRYFL--TNRFMVYM-YNQGSTSFHSPNIPA 94

  Fly   130 KTEVDLCHYQGHIRGKPESVVALSTCDGALDGIV--------IDGRQTYFIHPHIDGRGRLQDDH 186
            :     |:|||||:|.|.||..||||.| |.|.:        |:..|:.|...||..:...::..
Mouse    95 Q-----CYYQGHIKGYPNSVATLSTCSG-LRGFLQFENVSYGIEPLQSAFTSQHIVYKLGNKEKE 153

  Fly   187 YLLKQADMH---PTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRR 248
            .:..:...:   |||.                          ||               |:.|:.
Mouse   154 LIFNKNSRNIEMPTNY--------------------------GI---------------LINKKP 177

  Fly   249 QADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFV 313
                     :.|:. |.:..|:|:.||||..:|.....::..|......|.::||:::..|.:.:
Mouse   178 ---------KSPFK-NLFPLYLEMSIVVDKALYDYLGSDSNIVTNKIIEIISLINSVFAQLKVTI 232

  Fly   314 ALVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPI 378
            .|..:.:|::.|:|....:.|..|..||.::...|.| .|:|.|.|.....:. ..:|....|.:
Mouse   233 VLSSLELWSDKNKIPTVGEADELLHKFLEWKQAYLTL-RPHDVAYLFIYNEYP-NYMGATYPGKM 295

  Fly   379 CTYEYSGGVSMQHSPNP------AMVATTMAHEMGHNFGMEHDTSD-CHCRDEKCVMAASSTSFI 436
            ||..||.|::|.  |..      :::.|.|   :|.:.|:.:|..: |:|.:..|:|...:..:.
Mouse   296 CTAHYSAGITMY--PKDMTLEAFSVILTQM---LGLSLGISYDEPEKCYCSESICIMNPRAMQYG 355

  Fly   437 PV-NWSSCSIDQLTIAFSRGMNYCLRNKPE-RLFESPTCGNGFVEPGEQCDCGLPEHC-ENACCN 498
            .| ::|:||::......|.....||:|||: :...:..||||.||..|.||||....| .::||.
Mouse   356 GVKSFSNCSLNDFEHFKSNEGAKCLQNKPQMQRTAAAVCGNGKVEGDEICDCGSEAECGPDSCCE 420

  Fly   499 AQTCMLHSKNATC----ATGECC-------DLTTCRPKLAGSACREAENECDLPEYCTGESEYCP 552
            ...|:|.:..| |    .:..||       :...|||        |....||:||.|.|.|..||
Mouse   421 PNRCVLKAGRA-CDSKSPSSTCCKNCQFLPEKHQCRP--------EKHLYCDIPEVCNGSSGNCP 476

  Fly   553 ADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWGPTGDNSEH-CYNK-NTEGTRLGNCGYNRLN 615
            .||...:...|......|::|.|......|.:::|....|:.. ||.: ..:..|.||||.:..|
Mouse   477 PDVTINNGHVCKESGTICYNGDCPDLDRVCESIYGAGSVNAPFACYEEIQGQNDRFGNCGKDNRN 541

  Fly   616 KTFLRCEEQHVNCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQT-TDPG 679
            : ::.|..:::.||.|.|.: ..|:.:...:.:..|..|.....|:  |.|  ||.|... .||.
Mouse   542 R-YVFCGWRNLICGRLICTY-PTRMPYNPPNNSTASVIYAFVRDKV--CIT--VDFGSSVKEDPL 600

  Fly   680 LTPNGAKCGVDKMCVDQRCLPVDAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGFGGESCSKAG 744
            ...|||.|.:|::|::..|:....:|.:  .|.|...|:|||:|||.|.|||:.|:...:|..
Mouse   601 RVANGATCDLDRICLNGVCVESRFLRDQ--SKTCSSKCHGNGVCNSHGVCHCNAGYSPPNCQY-- 661

  Fly   745 SGGSPDSGPATDPNGSVGF---------------KRFLYVLFFFVLPVVALF-----WFLYHCYK 789
                    |.|..:.|:..               |::|..|:..::.:.::|     |
Mouse   662 --------PTTKRSASLWSGKHDLPMERASKNQEKKWLLSLYIVLIILASVFLIGTGW------- 711

  Fly   790 NGMLTRGKLADNILKSSGGSKPIT 813
            .|:...|...:..:.|...|:..|
Mouse   712 KGLKQCGSKEEESMSSESKSEDST 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	34/118 (29%)
		Reprolysin	269..464	CDD:279729	52/202 (26%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	51/200 (26%)
		Disintegrin	479..555	CDD:278623	28/87 (32%)
		ACR	558..701	CDD:214743	38/145 (26%)
Adam32	NP_700446.2	Pep_M12B_propep	40..144	CDD:279848	36/126 (29%)
		Reprolysin	188..384	CDD:279729	52/202 (26%)
		ZnMc_adamalysin_II_like	188..382	CDD:239797	51/200 (26%)
		Disintegrin	400..479	CDD:278623	28/87 (32%)
		ACR	483..622	CDD:214743	38/144 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	720..754		3/16 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920