DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and adam17a

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_005158775.1	Gene:	adam17a / 324142	ZFINID:	ZDB-GENE-030131-2862	Length:	848	Species:	Danio rerio

Alignment Length:	1051	Identity:	212/1051 - (20%)
Similarity:	304/1051 - (28%)	Gaps:	398/1051 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LNTCLQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRTKRSLLTTLDATDGLH 78
            ||:.|....:.||.....|......:.||..:|...::|.::      |..:..|||   ...|.
Zfish    41 LNSLLSDFEVLPASGLQLHSVRKRDADAHSHVERLVSFTALQ------RNFKLYLTT---NTQLF 96

  Fly    79 TPQISLSYTHE-GKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTKTEVDLCHYQGHI 142
            |...|..:..| ||....|:|             .||                      :::||:
Zfish    97 TENFSAVFVDENGKEDQFDVQ-------------IQN----------------------YFKGHV 126

  Fly   143 RGKPESVVALSTCDGALDGIVIDGRQTYFIHP-------HIDGR---GRLQDDHYLLKQADMHPT 197
            .|:..|.|............:|.....|.:.|       ..|||   .|.:|    :|......:
Zfish   127 VGEEHSRVQAHIDGDEFSAHIITEETEYNVEPLWRFTETPPDGRLLVYRSED----IKNISRLSS 187

  Fly   198 NATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDSSQLIRGPYN 262
            ...|||.|           ||.                    ...|..:.|.|::..::...|:|
Zfish   188 PKVCGYVN-----------ADA--------------------QELLPEEARAAEEMEEMKEEPHN 221

  Fly   263 ANKYSSYVE------LVIVVDNKVYKNF---QENTKKVHQYCKGIANIINALYVPLNIFVALVGV 318
            ..:.|::.:      |::|.|::.||:.   :|:|                   .||..:.|:..
Zfish   222 RERRSTHDQKKNTCTLLLVADHRFYKHMGRAEEST-------------------TLNYLIELIDR 267

  Fly   319 V-------IWNES----------------------NEIEFSSDGDLTLRNFLNYRSTKLVLDHPN 354
            |       .|::.                      .|..::.||..|.|....:...||:.....
Zfish   268 VDDIYRNTSWDDDFKGYGVQIQQIIINKDPTKVAPGEFHYNMDGSPTGRKDGVWDVKKLLEQFSY 332

  Fly   355 D---------NAQLLTKENFAGGVVGKALKGP-------ICTYEY--SGGVSMQHSPNPAMVAT- 400
            |         .|.|.|.::|..|.:|.|...|       :|...|  |..|......|..:.:|
Zfish   333 DIAANASRACLAHLFTYQDFDDGTLGLAYVAPSKPGLGGLCPKPYYPSQSVKKPSYLNTGLTSTM 397

  Fly   401 -------------TMAHEMGHNFGMEHD---TSDCHCRDE---KCVMAASSTSFIPVN---WSSC 443
                         ...||:|||||.|||   .:.|...|:   |.||...:.|...||   :|:|
Zfish   398 NYGKTILTKEADLVTTHELGHNFGAEHDPDNIASCAPSDDQGGKYVMYPIAVSGDHVNNKHFSTC 462

  Fly   444 SIDQLTIAFSRGMNYCLRNKPERLFESPTCGNGFVEPGEQCDCGLPEHCENACCNAQTCMLHSKN 508
            |...::......:|.|...:..:|     |||..||..|.||.||....::.||.: .|... |.
Zfish   463 SKISVSKTLRIKVNQCFVERSSKL-----CGNSRVEEDEDCDPGLLHINDDPCCTS-NCKFR-KQ 520

  Fly   509 ATCA--TGECCDLTTCRPKLAGSACREA-ENECDLPEYCTGESEYCPADVFRRDTEPC-DGGQAY 569
            |.|:  ...||  ..|..:.|...|:|. ...|.....|||.|..||......|...| |.|:
Zfish   521 AQCSDRNSPCC--KNCMFESADKVCQEVITATCKGTSQCTGNSSECPTPGNLEDNTECVDKGR-- 581

  Fly   570 CFHGTCRSHSNQCRTLWGPTGDNSEHCYNKNTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCI 634
            |.:|.||..   |..:     .|.|.|                       .|.|...:|.
Zfish   582 CQNGQCRPF---CEAV-----HNLESC-----------------------ACNETENSCK----- 610

  Fly   635 HLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCL 699
                                       |.||.                            |:.|.
Zfish   611 ---------------------------VCCRK----------------------------DELCT 620

  Fly   700 PVDAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGF--GGESCSKAGSGGSPDSGPATDPNGSVG 762
            |.               .||......|....|.|||  |...|.|.
Zfish   621 PF---------------LNGGSFLYLRKGKPCTVGFCDGAGKCMKQ------------------- 651

  Fly   763 FKRFLYVLFFFVLPVVALFWFLYHCYKNGMLTRGK-LADNILKSSGGS----------------- 809
                       |..|:...|....  |..:.|.|| |||||:    ||
Zfish   652 -----------VQDVIERLWDFID--KLNINTFGKFLADNIV----GSVVVFSLLFWIPISILVH 699

  Fly   810 ---KPITTRTNQNGTGPPPSNGLLKSTPSSTDDMDSALLKSPSDSTPSAGLFGKFDGFTLRPLND 871
               |.:..:..:|.....||..:|        ::.|..|.|....|..:|:
Zfish   700 CVDKRLDEQYEENTKMMYPSQMVL--------EVCSRALNSERRDTEQSGI-------------- 742

  Fly   872 ASSPASNYNGPNVAFVQPTVQQ-DGPQRMAPPPPVVKPGTAPIHPPSPKPEATWVRPAPALPPPN 935
            .:.|.|  .||:..|...|... :||.|     |.:..||.....|.|.......:...|....|
Zfish   743 GARPHS--QGPSCTFTSSTTSALNGPYR-----PRLHTGTGDARRPRPSQPLRRTQSGSAANGHN 800

  Fly   936 PGSTARPIISP 946
            .|...|.::||
Zfish   801 RGGPQRRLLSP 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	20/110 (18%)
		Reprolysin	269..464	CDD:279729	57/273 (21%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	57/271 (21%)
		Disintegrin	479..555	CDD:278623	25/78 (32%)
		ACR	558..701	CDD:214743	20/143 (14%)
adam17a	XP_005158775.1	Pep_M12B_propep	62..161	CDD:279848	26/142 (18%)
		ZnMc_TACE_like	233..486	CDD:239798	57/271 (21%)
		Reprolysin_2	257..471	CDD:290307	48/213 (23%)
		Disintegrin	493..567	CDD:278623	25/77 (32%)
		ADAM17_MPD	590..648	CDD:293303	21/163 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920