DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and Adam33

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_038960925.1	Gene:	Adam33 / 311425	RGDID:	1305278	Length:	799	Species:	Rattus norvegicus

Alignment Length:	889	Identity:	282/889 - (31%)
Similarity:	398/889 - (44%)	Gaps:	143/889 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LFLLPLLLLNTC-LQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRT--KRSL 67
            :.||.||||..| |....:.|..|      .||....|.||:              |:|  |.:|
  Rat    15 MLLLLLLLLPACPLLSARMFPGNA------GGELVTPHWVLD--------------GKTWLKVTL 59

  Fly    68 LTTLDATD-GLHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTK- 130
            ...:...| ||      ::...||:.::::|::|..||               .||:..|.:::
  Rat    60 KEQISKPDSGL------VALKAEGQDLLLELEKNHRLL---------------APGYTETYYSRD 103

  Fly   131 --------TEVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHY 187
                    ...|.|||||.:||..||.|.||||.|....||:..:.:|::||.:.|..:....|.
  Rat   104 GQPIVLSPNHTDHCHYQGCVRGFRESWVVLSTCSGMSGLIVLSSKVSYYLHPWMPGDTKDFPTHK 168

  Fly   188 LLKQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADD 252
            :.:...:..      :...|.|.:..::.     |: ..:|.:|.|           |.||:|.
  Rat   169 IFRVEQLFT------WRGARKDKNSQFKA-----GM-ARLPHVPHR-----------RMRREAR- 209

  Fly   253 SSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVG 317
                 |.|       .|:||.||.|:.::...::|.....|....|||.::.:...|:|.:.|.|
  Rat   210 -----RSP-------KYLELYIVADHALFLLQRQNLNHTRQRLLEIANCVDQILRTLDIQLVLTG 262

  Fly   318 VVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYE 382
            :.:|.|.:....:.|.:.||..||.:| ..|.:..|:|:.||||...|.|..||.|....:|..|
  Rat   263 LEVWTEQDHSRITQDANETLWAFLQWR-RGLWVRRPHDSTQLLTGRTFQGTTVGLAPVEGMCHAE 326

  Fly   383 YSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSDCHCRDEK-----CVMAASSTSFIPVNWSS 442
            .|||||..||..|...|.|||||:||:.|:.||...| |.:..     |||.|::....|..:|:
  Rat   327 SSGGVSTDHSELPIGTAATMAHEIGHSLGLHHDPEGC-CMEADAEQGGCVMEAATGHPFPRVFSA 390

  Fly   443 CSIDQLTIAFSRGMNYCLRN--KPERLFESPTCGNGFVEPGEQCDCGLPEHCENACCNAQTCMLH 505
            ||..||...|.:|...||.|  .|..|.....|||||||..|:||||..:...:.||.|..|.|.
  Rat   391 CSRRQLRTFFRKGGGACLSNVSAPGLLVLPSRCGNGFVEAEEECDCGSGQKRPDPCCFAHNCSLR 455

  Fly   506 SKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYC 570
            : .|.||.|:||  ..|..|.||:.||.|.|:|||||:|||.|.:|||||:..|..||..|:.||
  Rat   456 A-GAQCAQGDCC--ARCLLKPAGTPCRPAANDCDLPEFCTGTSPHCPADVYLLDGSPCAEGRGYC 517

  Fly   571 FHGTCRSHSNQCRTLWGPTGDNS-EHCYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHC 633
            ..|.|.:...||:.||||....: |.|:.: |:.|...||||.:. ..:||.|.::...||.|.|
  Rat   518 LDGWCPTLEKQCQQLWGPGSQPAPEPCFQQMNSVGNSQGNCGQDS-KGSFLPCTQRDAQCGKLLC 581

  Fly   634 IHLNERLEFGMESAAVLSHSYISHDRKI------VACRTALV--DLGLQTTDPGLTPNGAKCGVD 690
                    .|.:...::.| .::.|..|      |.||.|.|  |..|.....||...|.:||..
  Rat   582 --------QGGKPNPLVPH-VVTVDSTILLKGRQVLCRGAFVLPDTHLDQLGLGLVEPGTRCGPR 637

  Fly   691 KMCVDQRCLPVDAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSGPAT 755
            .:|.::.|  .:|..|:  .:.|...|:..|:|||..:|||..|:....|.|.|.|||.|||||.
  Rat   638 MVCQERHC--QNATSQE--LERCSSGCHNRGVCNSNRNCHCAAGWAPPFCDKPGLGGSVDSGPAQ 698

  Fly   756 DPNGSVGFKRFLYVLFFFVLPVV---ALFWFLYH----CYKNGMLTRGKLADNILKSSGGSKPIT 813
            ..|.. .|.  |.:|..|:||::   .|.|..|.    |.:.|...|.....|..:..|...|:.
  Rat   699 SANPD-AFP--LAMLLSFLLPLLPGAGLAWCYYQLPTLCQQPGRCCRRDALCNRDQPLGSVHPVE 760

  Fly   814 TRTNQNGTGPPPSNGLLKSTPSSTDDMDSALLKSPSDSTPSAGL 857
            ..:...|...|||.       ..|.||:..:...|.....:.||
  Rat   761 FGSIITGEPSPPSK-------CGTSDMEREVRVGPCLLLDARGL 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	33/119 (28%)
		Reprolysin	269..464	CDD:279729	73/201 (36%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	72/197 (37%)
		Disintegrin	479..555	CDD:278623	37/75 (49%)
		ACR	558..701	CDD:214743	47/152 (31%)
Adam33	XP_038960925.1	Pep_M12B_propep	41..170	CDD:396235	43/163 (26%)
		ZnMc_adamalysin_II_like	213..410	CDD:239797	72/198 (36%)
		DISIN	429..503	CDD:214490	38/76 (50%)
		ACR	505..647	CDD:214743	47/153 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4127
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	439	1.000	Inparanoid score	I1619
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0000154
OrthoInspector	1	1.000	-	-		otm45677
orthoMCL	1	0.900	-	-		OOG6_101958
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.970