Protein Alignment Meltrin and Adam33

DIOPT Version :10

• Sequence 1: NP_001027575.1
• Gene: Meltrin / 3772109
• FlyBaseID: FBgn0265140
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: NP_001382042.1
• Gene: Adam33 / 311425
• RGDID: 1305278
• Length: 780
• Species: Rattus norvegicus
• Alignment Length: 859
• Identity: 275/859 - (32%)
• Similarity: 389/859 - (45%)
• Gaps: 138/859 - (16%)

  Fly     6 LFLLPLLLLNTC-LQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRT--KRSL 67
            :.||.||||..| |....:.|..|      .||....|.||:              |:|  |.:|
  Rat    15 MLLLLLLLLPACPLLSARMFPGNA------GGELVTPHWVLD--------------GKTWLKVTL 59

  Fly    68 LTTLDATD-GLHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTK- 130
            ...:...| ||      ::...||:.::::|::|..||               .||:..|.:::
  Rat    60 KEQISKPDSGL------VALKAEGQDLLLELEKNHRLL---------------APGYTETYYSRD 103

  Fly   131 --------TEVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHY 187
                    ...|.|||||.:||..||.|.||||.|....||:..:.:|::||.:.|..:....|.
  Rat   104 GQPIVLSPNHTDHCHYQGCVRGFRESWVVLSTCSGMSGLIVLSSKVSYYLHPWMPGDTKDFPTHK 168

  Fly   188 LLKQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADD 252
            :.:...:..      :...|.|.:..::.     |: ..:|.:|.|           |.||:|.
  Rat   169 IFRVEQLFT------WRGARKDKNSQFKA-----GM-ARLPHVPHR-----------RMRREAR- 209

  Fly   253 SSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVG 317
                 |.|       .|:||.||.|:.::...::|.....|....|||.::.:...|:|.:.|.|
  Rat   210 -----RSP-------KYLELYIVADHALFLLQRQNLNHTRQRLLEIANCVDQILRTLDIQLVLTG 262

  Fly   318 VVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYE 382
            :.:|.|.:....:.|.:.||..||.:| ..|.:..|:|:.||||...|.|..||.|....:|..|
  Rat   263 LEVWTEQDHSRITQDANETLWAFLQWR-RGLWVRRPHDSTQLLTGRTFQGTTVGLAPVEGMCHAE 326

  Fly   383 YSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSDCHCRDEK-----CVMAASSTSFIPVNWSS 442
            .|||||..||..|...|.|||||:||:.|:.||...| |.:..     |||.|::....|..:|:
  Rat   327 SSGGVSTDHSELPIGTAATMAHEIGHSLGLHHDPEGC-CMEADAEQGGCVMEAATGHPFPRVFSA 390

  Fly   443 CSIDQLTIAFSRGMNYCLRN--KPERLFESPTCGNGFVEPGEQCDCGLPEHCENACCNAQTCMLH 505
            ||..||...|.:|...||.|  .|..|.....|||||||..|:||||..:...:.||.|..|.|.
  Rat   391 CSRRQLRTFFRKGGGACLSNVSAPGLLVLPSRCGNGFVEAEEECDCGSGQKRPDPCCFAHNCSLR 455

  Fly   506 SKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYC 570
            : .|.||.|:||  ..|..|.||:.||.|.|:|||||:|||.|.:|||||:..|..||..|:.||
  Rat   456 A-GAQCAQGDCC--ARCLLKPAGTPCRPAANDCDLPEFCTGTSPHCPADVYLLDGSPCAEGRGYC 517

  Fly   571 FHGTCRSHSNQCRTLWGPTGDNS-EHCYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHC 633
            ..|.|.:...||:.||||....: |.|:.: |:.|...||||.:. ..:||.|.::...||.|.|
  Rat   518 LDGWCPTLEKQCQQLWGPGSQPAPEPCFQQMNSVGNSQGNCGQDS-KGSFLPCTQRDAQCGKLLC 581

  Fly   634 IHLNERLEFGMESAAVLSHSYISHDRKI------VACRTALV--DLGLQTTDPGLTPNGAKCGVD 690
                    .|.:...::.| .::.|..|      |.||.|.|  |..|.....||...|.:||..
  Rat   582 --------QGGKPNPLVPH-VVTVDSTILLKGRQVLCRGAFVLPDTHLDQLGLGLVEPGTRCGPR 637

  Fly   691 KMCVDQRCLPVDAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSGPAT 755
            .:|.::.|  .:|..|:  .:.|...|:..|:|||..:|||..|:....|.|.|.|||.|||||.
  Rat   638 MVCQERHC--QNATSQE--LERCSSGCHNRGVCNSNRNCHCAAGWAPPFCDKPGLGGSVDSGPAQ 698

  Fly   756 DPNGSVGFKRF-LYVLFFFVLPVV---ALFWFLYH----CYKNGMLTRGKLADNILKSSGGSKPI 812
            ..|...    | |.:|..|:||::   .|.|..|.    |.:.|...|.....|..:..|...|:
  Rat   699 SANPDA----FPLAMLLSFLLPLLPGAGLAWCYYQLPTLCQQPGRCCRRDALCNRDQPLGSVHPV 759

  Fly   813 TTRTNQNGTGPPPS 826
            ...:...|...||:
  Rat   760 EFGSIITGEPSPPN 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	53..174	CDD:460254	35/132 (27%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	72/197 (37%)
		Disintegrin	479..554	CDD:459709	36/74 (49%)
		ACR	558..701	CDD:214743	47/152 (31%)
		PHA03247	<823..1261	CDD:223021	2/4 (50%)
		PHA03247	<1220..1392	CDD:223021
Adam33	NP_001382042.1	Pep_M12B_propep	41..170	CDD:460254	43/163 (26%)
		ZnMc_adamalysin_II_like	213..410	CDD:239797	72/198 (36%)
		DISIN	429..503	CDD:214490	38/76 (50%)
		ACR	505..647	CDD:214743	47/153 (31%)