DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and Adam19

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001153700.1	Gene:	Adam19 / 303068	RGDID:	1585017	Length:	920	Species:	Rattus norvegicus

Alignment Length:	998	Identity:	307/998 - (30%)
Similarity:	444/998 - (44%)	Gaps:	207/998 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SEGEKSKAHPVLEEFSTYTVIRPQVEHGRTKRSLLTTLDATDGLHTPQISLSYTHEGKRVVVDLQ 98
            :.|.|..:.|:..|     :|.||.....:.|.         |.|.....|....||:.:::||:
  Rat    32 TRGSKEDSPPLQHE-----LIIPQWRTSESPRG---------GKHPLTAELRVMAEGRELILDLE 82

  Fly    99 RNDLLLPNSHFLRYQNASRGATPGHVVTTFTKTEVDLCHYQGHIRGKPESVVALSTCDGALDGIV 163
            :|:.|...::......||     |:..||..|:| |.|.|.|.:|...||.|.||||.|....|:
  Rat    83 KNEHLFAPAYTETCYTAS-----GNPQTTTLKSE-DHCFYHGTVRKVDESSVTLSTCRGIRGLII 141

  Fly   164 IDGRQTYFIH--PHIDGRGRLQDDHYLLKQADMHPTNATCGYDNHRD-------DHSHDYEKADG 219
            :....:|.|.  |:.|.:.|:    |..:...:.|.|  ||:::.|.       ..:|..:|..
  Rat   142 VRSNLSYIIEPVPNSDNQHRI----YRSEHLKLPPGN--CGFEHSRPTSKDWTLQFTHQTKKQP- 199

  Fly   220 DNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNF 284
                                      :|.:.:|...:           .||||.:|.|   |..|
  Rat   200 --------------------------RRMKREDLHSM-----------KYVELYLVAD---YAEF 224

  Fly   285 QEN------TKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNESNEIEFSSDGDLTLRNFLNY 343
            |:|      ||  |:..: |||.::..|..|:|.:||||:.:|...::.|.|.:...||.:||::
  Rat   225 QKNRHDQDATK--HKLME-IANYVDKFYRSLSIRIALVGLEVWTHGDKCEVSENPYSTLWSFLSW 286

  Fly   344 RSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPNPAMVATTMAHEMGH 408
            | .||:....:|||||:|..:|.|..:|.|....:|:...||||||.||.|...||:|:|||:||
  Rat   287 R-RKLLTQKSHDNAQLITGRSFQGTTIGLAPLMAMCSVYQSGGVSMDHSENAIGVASTVAHEIGH 350

  Fly   409 NFGMEHDTSDC---HCRDEKCVMAASSTSFIPVNWSSCSIDQLTIAFSRGMNYCLRNKPE--RLF 468
            ||||.||::.|   ...|..|:|||::....|..:|||:..:|......|...||.|.|:  .|:
  Rat   351 NFGMSHDSAHCCSTSAADGGCIMAAATGHPFPKVFSSCNRKELDRYLQSGGGMCLSNMPDTRTLY 415

  Fly   469 ESPTCGNGFVEPGEQCDCGLPEHCENACCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACRE 533
            ....||||::|.||:||||..:.|:|.||||..|.| .:.|.||.|.||.  .|:....|:.|||
  Rat   416 GGRRCGNGYLEDGEECDCGEEDECKNPCCNASNCTL-KEGAECAHGSCCH--QCKLVAPGTQCRE 477

  Fly   534 AENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWGPTGDNS-EHCY 597
            ...:|||||:|||:|.:||.:.::.|..||:||||||::|.|.::..||:.||||....: :.|:
  Rat   478 QVRQCDLPEFCTGKSPHCPTNYYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPALDLCF 542

  Fly   598 NK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKI 661
            .: |..|...|||| ..||..:.:|..:...||.:.|.....|   .:||.||...:.|:.:.:.
  Rat   543 ERVNAAGDTYGNCG-KGLNGKYRKCSPRDAKCGKIQCQSTQAR---PLESNAVSIDTTITLNGRR 603

  Fly   662 VACRTALVDLGLQ-------TTDPGLTPNGAKCGVDKMCVDQRCLPVDAVRQKGMGKPCPEDCNG 719
            :.||...|..|.:       ..||||...|.|||.:.:|.:.:|........:|.||    .|||
  Rat   604 IHCRGTHVYRGPEEEEGEGDMLDPGLVMTGTKCGHNHICFEGQCRNTSFFETEGCGK----KCNG 664

  Fly   720 NGICNSRGHCHCDVGFGGESCSKAGSGGSPDSGPATDPNGSVGFKRFLYVLFFFVLPVVALFWFL 784
            :|:||:..:|||..|:....|:..|.|||.||||.  |..|.|   .:....|..|.|:|:...|
  Rat   665 HGVCNNNKNCHCFPGWAPPFCNTPGDGGSIDSGPL--PPKSAG---PVIAGVFSALFVLAVLVLL 724

  Fly   785 YHCYKNGMLTRGKLADNILKSSGGSKPITT------------RTNQN-GTG-------------- 822
            .|||:              :|....||...            |.:|| |||
  Rat   725 CHCYR--------------QSHKLGKPSALPFKLRQQFSCPFRVSQNGGTGHANPTFKLQTPQGK 775

  Fly   823 -------------------PPPSNGLLKSTPSSTDDMDSALLKSPSDSTPSAGLFGKFDGFTLRP 868
                               |||....::|.|:..    .|.|...:.|:|.||...:......||
  Rat   776 RKVTNTPETLRKPSHPPPRPPPDYLRVESHPAPL----PAHLNRAAGSSPEAGAQIERKESARRP 836

  Fly   869 LNDASSPASNYNGPNVAFVQPTVQQDGPQRMAPPPP------VVKP-GTAPIHPPSPKPEATWVR 926
            ......|.:    ||....|...:...||:..|..|      |.:| ||:..|||:..|:
  Rat   837 PPSRPMPPA----PNCLLSQDFSRPRPPQKALPANPVPGQRTVPRPGGTSLFHPPTTGPQ----- 892

  Fly   927 PAPALPPPNPGSTARPIISPPKL 949
                  ||.|     |.:|.|||
  Rat   893 ------PPRP-----PAVSVPKL 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	33/111 (30%)
		Reprolysin	269..464	CDD:279729	82/203 (40%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	81/201 (40%)
		Disintegrin	479..555	CDD:278623	37/75 (49%)
		ACR	558..701	CDD:214743	50/151 (33%)
Adam19	NP_001153700.1	Pep_M12B_propep	62..162	CDD:279848	33/105 (31%)
		Reprolysin	211..409	CDD:279729	82/204 (40%)
		ZnMc_adamalysin_II_like	211..407	CDD:239797	81/202 (40%)
		DISIN	440..500	CDD:214490	29/62 (47%)
		ACR	502..650	CDD:214743	50/151 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4127
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74925
Inparanoid	1	1.050	439	1.000	Inparanoid score	I1619
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0000154
OrthoInspector	1	1.000	-	-		otm45677
orthoMCL	1	0.900	-	-		OOG6_101958
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.870