DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and Adam23

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001025070.2	Gene:	Adam23 / 301460	RGDID:	1305739	Length:	828	Species:	Rattus norvegicus

Alignment Length:	810	Identity:	223/810 - (27%)
Similarity:	359/810 - (44%)	Gaps:	147/810 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 NTCLQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRTKRSLLTTLDATDGLHT 79
            ::.:|:.|..|:. ..::.::..:|..| ||:     |..|.|.:|.:             .:|.
  Rat   100 SSAVQKEITLPSR-LVYYINQDSESPYH-VLD-----TKARHQQKHNK-------------AVHL 144

  Fly    80 PQISLSYTHEGKRVVVDLQRNDLLLPNSHF-LRYQNASRGATPGHVVTTFTKTEVDLCHYQGHIR 143
            .|.|......|.:.::||..|:.||.:.:. :.|::..:..:.|.          :.|:|.|.||
  Rat   145 AQASFQIEAFGSKFILDLILNNGLLSSDYVEIHYEDGKQMYSKGG----------EHCYYHGSIR 199

  Fly   144 GKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTNATCGYDNHRD 208
            |..:|.||||||:| |.|:..|....|.|.|.
  Rat   200 GVKDSRVALSTCNG-LHGMFEDDTFVYMIEPL--------------------------------- 230

  Fly   209 DHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTL-------------------LRKRRQADDSS 254
            :.:|| ||:.|.       |.:..:...|::|:.:                   ||:|::|.:.|
  Rat   231 ELTHD-EKSTGR-------PHIIQKTLAGQYSKQMKNLSTDGSDQWPLLPELQWLRRRKRAVNPS 287

  Fly   255 QLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALY-VPLNIFVALVGV 318
               ||.:...|   |:||:||.|:|.||..:.:....:.:.|.:.|:::::| ..||..|.||.|
  Rat   288 ---RGVFEEMK---YLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAV 346

  Fly   319 VIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENF---------AGGVVGKAL 374
            ..|.|.::|:.:.:....|..|..||  :.:..|. |...|:::..|         .|||..:.
  Rat   347 ETWTEKDQIDITINPVQMLHEFSKYR--QRIKQHA-DAVHLISRVTFHYKRSSLSYFGGVCSRV- 407

  Fly   375 KGPICTYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSD----CHCRDE--KCVMAASST 433
                      .||.:.....|..||..::..:..|.|::.:.|.    |.|.:.  .|:|..:..
  Rat   408 ----------KGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPSSRKPKCECIESWGGCIMEETGV 462

  Fly   434 SFIPVNWSSCSIDQLTIAFSRGMNYCLRNKPERLFESPTCGNGFVEPGEQCDCGLPEHCENACCN 498
            |. ...:|.|||.:......||...||.|:|.:|||...||||:||.||:||||....|...||
  Rat   463 SH-SRKFSKCSILEYRDFLQRGGGACLFNRPTKLFEPTECGNGYVEAGEECDCGFHVECYGVCC- 525

  Fly   499 AQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPC 563
             :.|.| |..|.|:.|.||:.|:|..:..|..||:|.|.||:.|||||:|..||.::.::|...|
  Rat   526 -KKCSL-SNGAHCSDGPCCNNTSCLFQSRGYECRDAVNSCDITEYCTGDSGQCPPNLHKQDGYAC 588

  Fly   564 DGGQAYCFHGTCRSHSNQCRTLWGPTGDNSE-HCYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHV 626
            :..|..|::|.|::..|||:.:||.....|: .||.| |||||..||||.:  ...:::|.:..|
  Rat   589 NQNQGRCYNGECKTRDNQCQYIWGTKASGSDKFCYEKLNTEGTEKGNCGKD--GDRWIQCSKHDV 651

  Fly   627 NCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPGLTPNGAKCGVDK 691
            .||.|.|.:|......|.....::..|:. |..:::.|..|.|.|. ..||.|...:|.......
  Rat   652 FCGFLLCTNLTRAPRIGQLQGEIIPTSFY-HQGRVIDCSGAHVVLD-DDTDVGYVEDGTPLCPSM 714

  Fly   692 MCVDQRCLPVDAVRQKGMGKPCPED-----CNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDS 751
            ||:|::||.:.|:....    ||.|     |:|:|:|::...|.||..:.|..||......:|:.
  Rat   715 MCLDRKCLQIQALNMSS----CPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIRDPVRNPNP 775

  Fly   752 GPATDPNGSVGFKRFLYVLFFFVLPVVALF 781
            .....|..::...|.:..:...||.:..:|
  Rat   776 PKDEGPKVNMATSRLIGAVLGTVLALGVIF 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	30/110 (27%)
		Reprolysin	269..464	CDD:279729	54/210 (26%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	53/208 (25%)
		Disintegrin	479..555	CDD:278623	35/75 (47%)
		ACR	558..701	CDD:214743	47/144 (33%)
Adam23	NP_001025070.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	73	1.000	Domainoid score	I9011
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920