DRSC/TRiP Functional Genomics Resources

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Protein Alignment Meltrin and Adam10

DIOPT Version :9

Sequence 1:NP_001027575.1 Gene:Meltrin / 3772109 FlyBaseID:FBgn0265140 Length:1407 Species:Drosophila melanogaster
Sequence 2:NP_062127.1 Gene:Adam10 / 29650 RGDID:2032 Length:749 Species:Rattus norvegicus


Alignment Length:656 Identity:150/656 - (22%)
Similarity:243/656 - (37%) Gaps:158/656 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 TYTVIRPQVEHGRTKRSLLTTLDATDGLHTPQ-ISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQ 113
            :|.|.....:|.|.||::         .|..| :.|.:...|::..:.::|:..|..:...:...
  Rat    36 SYNVDSLHQKHQRAKRAV---------SHEDQFLLLDFHAHGRQFNLRMKRDTSLFSDEFKVETS 91

  Fly   114 NASRGATPGHVVTTFTKTEVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHP---H 175
            |........|:             |.|||.|:..|....|..||..:|.:.....|::|.|   :
  Rat    92 NKVLDYDTSHI-------------YTGHIYGEEGSFSHGSVVDGRFEGFIQTRGGTFYIEPAERY 143

  Fly   176 IDGRGRLQDDHYLLKQADMHPTNATCGYDNHRDD--HSHDYEKADGDNGLGGGIPSLPLRLDGGE 238
            |  :.|:...|.::               .|.||  :.|.|       |..||.      .|...
  Rat   144 I--KDRILPFHSVI---------------YHEDDINYPHKY-------GPQGGC------ADHSV 178

  Fly   239 FSRTLLRK----------RRQADDSS-----QLIRGPYNANKYSSYVELVIVVDNKVYKNFQENT 288
            |.|  :||          |..:::.:     :|:|.........:..:|.|..|:..:|.:....
  Rat   179 FER--MRKYQMTGVEEGTRAHSEEHAASMGPELLRKKRTTLAERNTCQLYIQTDHLFFKYYGTRE 241

  Fly   289 KKVHQYCKGIANIINALYVPLNIFVALVGVVIWNESNEIEFSSD----------GDLTLRNFLNY 343
            ..:.|....: ..|:.:|...: |..:..:....:...|..:||          .::.:..||..
  Rat   242 AVIAQISSHV-KAIDTIYQTTD-FSGIRNISFMVKRIRINTTSDEKDPTNPFRFPNIGVEKFLEL 304

  Fly   344 RSTKLVLDHPNDN---AQLLTKENFAGGVVGKA-------LKGPICTYE--YSGG---------V 387
            .|     :..:|:   |.:.|..:|..||:|.|       ..|.||...  ||.|         :
  Rat   305 NS-----EQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGII 364

  Fly   388 SMQ----HSPNPAMVATTMAHEMGHNFGMEHDT-SDCHCRDEK---------CVMAASSTSFIPV 438
            ::|    |.| |.:...|.|||:|||||..||: ::|...:.|         .:|.|.:||...:
  Rat   365 TVQNYGSHVP-PKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKL 428

  Fly   439 N---WSSCSIDQLTIAFSRGMNYCLRNKPERLFESPTCGNGFVEPGEQCDCGLPEHCENACC--- 497
            |   :|.|||..::....:..|.|.....:     |.||||.||.||:||||..:.|::.||   
  Rat   429 NNNKFSLCSIRNISQVLEKKRNNCFVESGQ-----PICGNGMVEQGEECDCGYSDQCKDECCFDA 488

  Fly   498 ---NAQTCMLH-SKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPAD---- 554
               ..:.|.|. .|..:.:.|.|| ...|..|.....||: :::|.....|.|.:..|||.    
  Rat   489 NQPEGKKCKLKPGKQCSPSQGPCC-TAQCAFKSKSEKCRD-DSDCAKEGICNGFTALCPASDPKP 551

  Fly   555 ---VFRRDTEPCDGGQAYCFHGTCRSHS-NQCRTLWGPTGDNSEHCY---NKNTEGTRLGNCGYN 612
               ...|.|:.|..||  |....|..:. .:|........|:.|.|:   .|....:...:.|..
  Rat   552 NFTDCNRHTQVCINGQ--CAGSICEKYDLEECTCASSDGKDDKELCHVCCMKKMAPSTCASTGSL 614

  Fly   613 RLNKTF 618
            :.||.|
  Rat   615 QWNKQF 620

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MeltrinNP_001027575.1 Pep_M12B_propep 64..174 CDD:279848 22/110 (20%)
Reprolysin 269..464 CDD:279729 56/242 (23%)
ZnMc_adamalysin_II_like 269..462 CDD:239797 56/240 (23%)
Disintegrin 479..555 CDD:278623 26/89 (29%)
ACR 558..701 CDD:214743 16/65 (25%)
Adam10NP_062127.1 Pep_M12B_propep 48..141 CDD:307618 24/114 (21%)
Cysteine switch 171..178 3/12 (25%)
ZnMc_TACE_like 221..460 CDD:239798 56/251 (22%)
DISIN 467..546 CDD:214490 24/80 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 705..749
SH3-binding. /evidence=ECO:0000255 709..716
SH3-binding. /evidence=ECO:0000255 723..729
Interaction with AP2A1, AP2A2 and AP2M1. /evidence=ECO:0000250|UniProtKB:O35598 735..749
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D162519at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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