DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meltrin and Adam7

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_064697.2	Gene:	Adam7 / 29641	RGDID:	62032	Length:	789	Species:	Rattus norvegicus

Alignment Length:	699	Identity:	208/699 - (29%)
Similarity:	308/699 - (44%)	Gaps:	107/699 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 KRSLLTTLDATDGLHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLR------------YQNAS 116
            |.|||...| .:.:|.......|..| ....:.|.|..|.|   |.|:            |.|..
  Rat    34 KLSLLQKRD-LERIHDSDTPEEYEEE-LLYEIKLGRKTLTL---HLLKAREFLALNYSETYYNIK 93

  Fly   117 RGATPGHVVTTFTKTEVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHP--HIDGR 179
            |     .:||...:. :|.|.|||.|..:.:|..::|||:| |.|......|.|.|.|  :.|
  Rat    94 R-----EMVTRHPQI-LDHCFYQGSIIHEFDSAASISTCNG-LRGFFRVNDQRYLIEPVKYSD-- 149

  Fly   180 GRLQDDHYLLKQADMHP--TNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSR- 241
               :.||.:.|.....|  ||.:|                                 :|..|::
  Rat   150 ---EGDHLVFKYNVKAPYATNYSC---------------------------------EGLNFTKK 178

  Fly   242 -TLLRKRRQADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINAL 305
             ||:..:...:...:    .|:..|   ::||.:|.|..||:...:...|:.:...|:.|.:|.:
  Rat   179 STLIDAKNIEEHKVE----DYHKEK---FIELFVVADEFVYRRNSKPQNKLRKRIWGMVNFVNMI 236

  Fly   306 YVPLNIFVALVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVV 370
            |..|||.|.|.|:.||:..:|||..|:.:.||.:|..::.|.|......|:..||:.:.....:.
  Rat   237 YKALNIRVTLTGMEIWSAGDEIEIVSNLESTLLHFSTWQETVLKKRKDFDHVILLSGKWLYTSMQ 301

  Fly   371 GKALKGPICTYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSDCHCRDEKCVMAASSTSF 435
            |.|..|.||....|..|.....|:..::...|||::||:.||.||...|.|...||||.|.|
  Rat   302 GIAYPGGICQTLRSCSVVKDLLPDVNIIGNRMAHQLGHSLGMRHDDFPCTCPLGKCVMGAGS--- 363

  Fly   436 IP-VNWSSCSIDQLTIAFSRGMNYCLRNK--PERLFESPTCGNGFVEPGEQCDCGLPEHCENACC 497
            || :.:|.||..|...........|:.|.  ||...:.|.|||..|:.||:||||..:.|.|.||
  Rat   364 IPAIKFSKCSQTQYQQFLKNQKPACILNNPLPEEFNDYPFCGNKKVDEGEECDCGPVQECTNPCC 428

  Fly   498 NAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEP 562
            :|..|:| ....||..||||:  :|:.|..|..||.|:||||:.|.|||.|..||.|..:.:..|
  Rat   429 DAHKCVL-KPGFTCVEGECCE--SCQMKKEGVICRPAKNECDISEVCTGYSPECPKDESQANGFP 490

  Fly   563 CDGGQAYCFHGTCRSHSNQCRTLW-GPTGDNSEHCYNKNTEGTRLGNCGYNRLNKTFLRCEEQHV 626
            |..|:.|||.|.|.:..:||..|: |...::...||..|.:|.|.|.|  ...:.||:.|||:.:
  Rat   491 CKNGEGYCFMGLCPTRDDQCAELFSGGAEESHSLCYRMNQKGNRFGYC--KNKDNTFVPCEEKDL 553

  Fly   627 NCGMLHC------IHLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPGLTPNGA 685
            .||.::|      .||.|...:.:::.    ...||     :.|:|..  |...:.|.||..:|.
  Rat   554 KCGKIYCTGGRRSAHLGEDKTYNLKNV----KQNIS-----IKCKTMF--LYHNSRDMGLVNSGT 607

  Fly   686 KCGVDKMCVDQRCLPVDAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVG 734
            |||...:|.:..|:.::......:   |...|:.|.:.::...|.|:.|
  Rat   608 KCGEGMVCSNGECIEMEKAYNSTI---CSSLCDENDVDDNEPDCQCEEG 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	35/121 (29%)
		Reprolysin	269..464	CDD:279729	64/197 (32%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	63/193 (33%)
		Disintegrin	479..555	CDD:278623	36/75 (48%)
		ACR	558..701	CDD:214743	44/149 (30%)
Adam7	NP_064697.2	Pep_M12B_propep	28..156	CDD:396235	39/138 (28%)
		Reprolysin	199..393	CDD:396140	65/199 (33%)
		DISIN	410..482	CDD:214490	36/74 (49%)
		ACR	486..623	CDD:214743	44/149 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..789
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I6987
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920