DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and Adam24

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_017455860.1	Gene:	Adam24 / 290774	RGDID:	1309066	Length:	740	Species:	Rattus norvegicus

Alignment Length:	700	Identity:	219/700 - (31%)
Similarity:	324/700 - (46%)	Gaps:	85/700 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 FTKTEVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLK-- 190
            |.:|:   |:|.|.:...|||:.||:||.|...||:.....||.|.|....   ...:|.|.|
  Rat   105 FVQTD---CYYLGFVDEDPESMAALTTCFGGFQGILQINDTTYKIKPKTPS---FTFEHLLYKID 163

  Fly   191 --QADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDS 253
              :..:||..  ||..               |..:.|.:                   |.|.:|.
  Rat   164 SEETQLHPMR--CGLT---------------DEEIAGQV-------------------RLQENDK 192

  Fly   254 SQLIRGPYNA-NKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVG 317
            |.|::..|.: ..:..|::|.:|:|::.:...:.||..|.:....|.|.||...:.::|.|||:|
  Rat   193 STLMQSIYGSWWSHGLYIKLALVIDHEQFLYRKSNTSLVLKDVFNIMNGINLSLLSVDINVALLG 257

  Fly   318 VVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYE 382
            :.||.:.|.|.. .|....|..|..:::.........|.|.|.....| |...|.|..|.:|...
  Rat   258 LTIWTQRNPIPV-QDIYTLLPAFCLWKTMNFNSQMAYDIAHLFVNYTF-GDYFGIAFVGTVCNKT 320

  Fly   383 YSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSDCHCRDEKCVMAASSTSFIPVNWSSCSIDQ 447
            :..||......|...:...:|||:|||.||.||...|.|.:..|:|:|:..|  ....|:||.:.
  Rat   321 FGCGVDRLFGDNFLTIGHIVAHEIGHNLGMPHDGILCSCGEGPCLMSATMES--SKKLSNCSYEF 383

  Fly   448 LTIAFSRGMNYCLRNKPER--LFESPTCGNGFVEPGEQCDCGLPEHCENACCNAQTCMLHSKNAT 510
            |....::  ..||:.:|..  :|....||||.|:.||:||||......|:.|...||:|.| .|.
  Rat   384 LWANIAK--KSCLQREPSSSDIFPMKICGNGVVDDGEECDCGSQSCGRNSRCCLPTCILKS-GAK 445

  Fly   511 CATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTC 575
            ||:|.||:. .|:.:.:|:.||..||||||||:|.|.|:.||.|.|.:....| .|..||:...|
  Rat   446 CASGLCCNF-KCQIQPSGTLCRTKENECDLPEWCNGTSKECPEDTFVQAGTSC-LGNGYCYEKRC 508

  Fly   576 RSHSNQCRTLWGPTG-DNSEHCYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNE 638
            .||.:.|:.::|... ..|:.||.: ||.|.|.||||..  ||.::|||...:.||.:.|..
  Rat   509 NSHDDHCKRVFGEHAMKASDRCYKELNTRGDRFGNCGLK--NKGYVRCETSDILCGRIQCAK--- 568

  Fly   639 RLEFGMESAAVLSHSYISHDRKI--VACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPV 701
                 :::..:|...|..|..:.  .:|.:....||::..|.|...:|..||...:|:.::|
  Rat   569 -----VKTFPILESHYTVHWTRFNDASCWSTDYHLGMKIADLGDIKDGTNCGPQHVCISRKC--- 625

  Fly   702 DAVRQKGMGKPC-PEDCNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSG-PA-TDPNGS--V 761
              |.:......| ||.||..||||::.|||||.|:....|...|:|||.||| || .|||.:  .
  Rat   626 --VNKPSWKSDCSPETCNMRGICNNKQHCHCDFGWSPPLCVDNGTGGSIDSGSPAPEDPNANKRK 688

  Fly   762 GFKRFLYVLFFFVLPVVALFWFLYHCYKNGMLTRGKLADNILKSSGGSKP 811
            |..:|:.:|...:..||.|| .|::.::...|:.|  .|...|....:||
  Rat   689 GIGKFIILLLPIIFVVVVLF-LLFYLFRTNRLSLG--GDKQAKKGEEAKP 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	18/45 (40%)
		Reprolysin	269..464	CDD:279729	57/194 (29%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	57/192 (30%)
		Disintegrin	479..555	CDD:278623	35/75 (47%)
		ACR	558..701	CDD:214743	41/146 (28%)
Adam24	XP_017455860.1	Pep_M12B_propep	42..160	CDD:396235	20/60 (33%)
		ZnMc_adamalysin_II_like	209..395	CDD:239797	56/191 (29%)
		DISIN	415..490	CDD:214490	36/76 (47%)
		ACR	492..628	CDD:214743	42/151 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0000154
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920