DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and Adamdec1

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_017455116.1	Gene:	Adamdec1 / 290338	RGDID:	1309861	Length:	468	Species:	Rattus norvegicus

Alignment Length:	469	Identity:	123/469 - (26%)
Similarity:	206/469 - (43%)	Gaps:	59/469 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 EFSTYTVIRPQ---VEHGRTKRSLLTTLDATDGLHTPQISLSYTHEGKRVVVDLQRNDLLL-PNS 107
            |.....::.|:   :...|...:..|...|.:..:.|::.......|:.::..|:|...|| |:.
  Rat    38 ELKPQKIVHPKKLPISQRRGLENNQTESYAKEERYAPEVQYQIILNGEEIIFHLKRTKHLLGPDY 102

  Fly   108 HFLRYQNASRGATPGHVVTTFTKTEVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFI 172
            ..:.|       :|.....|.....|..|:|:|||:....|:.::||||| |.|        ||.
  Rat   103 TEISY-------SPRREEMTRRSQNVKPCYYEGHIQNAKGSLASISTCDG-LRG--------YFT 151

  Fly   173 HPHIDGRGRLQDDHYLLKQADMHPTNATCGYDNHRDDHS---HDYEKADGDNGLGGGIPSLPLRL 234
            |         :|..|     .:.|..:|     ...:|:   |::|:              |..:
  Rat   152 H---------RDQKY-----QIMPLQST-----DEGEHAVIPHNWEE--------------PGAV 183

  Fly   235 DGGEFSRTLLRKRRQADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIA 299
            :.....:.:.|||.....|..|.....::.:...|:.|.:|:||..||.::.|..::..:...:.
  Rat   184 NYKHSEKQIGRKRSHLRTSRSLKSPNEDSLQGQKYIGLFLVLDNSYYKMYKGNVTRMRSFVFEVL 248

  Fly   300 NIINALYVPLNIFVALVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKEN 364
            |::|.:|..::|.|:|||:.||::.::|:...:...|..||:.:..:.|. ...:::||||:...
  Rat   249 NLLNVIYKTIDIQVSLVGMEIWSDRDKIKVVPNLGATFTNFMRWHYSNLG-QRIHNHAQLLSGAG 312

  Fly   365 FAGGVVGKALKGPICTYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSDCHCRDEKCVMA 429
            |..|.||.|....:||......:..:...|.|:|| .|:||:||..||:.......|....|||.
  Rat   313 FLHGRVGMAAANSLCTTSSVSVIEAKRKNNVALVA-LMSHELGHALGMQDVPYYTKCPSGSCVMN 376

  Fly   430 ASSTSFIPVNWSSCSIDQLTIAFSRGMNYCLRNKPE-RLFESPTCGNGFVEPGEQCDCGLPEHCE 493
            ...:|..|.::|:.|..:.....|.....||...|: :....|||||..::.||.||||.||.|.
  Rat   377 QYLSSKFPKDFSTVSRSRFQGFLSSRNTRCLLLAPDPKNIIKPTCGNRLLDMGEGCDCGSPEECT 441

  Fly   494 NACCNAQTCMLHSK 507
            |.||...||.|.|:
  Rat   442 NLCCEPLTCRLKSQ 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	28/110 (25%)
		Reprolysin	269..464	CDD:279729	56/194 (29%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	56/192 (29%)
		Disintegrin	479..555	CDD:278623	16/29 (55%)
		ACR	558..701	CDD:214743
Adamdec1	XP_017455116.1	Pep_M12B_propep	54..175	CDD:279848	35/155 (23%)
		Reprolysin	217..411	CDD:279729	56/195 (29%)
		ZnMc_adamalysin_II_like	217..408	CDD:239797	55/192 (29%)
		Disintegrin	427..>454	CDD:299186	15/26 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920