Protein Alignment Meltrin and ADAMDEC1

DIOPT Version :9

• Sequence 1: NP_001027575.1
• Gene: Meltrin / 3772109
• FlyBaseID: FBgn0265140
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: NP_055294.1
• Gene: ADAMDEC1 / 27299
• HGNCID: 16299
• Length: 470
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 150/534 - (28%)
• Similarity: 238/534 - (44%)
• Gaps: 102/534 - (19%)

  Fly     8 LLPLLLLNTCLQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQ---VEHGRTKRSLLT 69
            |||:|.|       |:| .:|.|..|:           .|.:.:.::.|:   :.|.|..::..|
Human    18 LLPVLWL-------IVQ-TQAIAIKQT-----------PELTLHEIVCPKKLHILHKREIKNNQT 63

  Fly    70 TLDATDGLHTPQISLSYTHEGKRVVVDLQRNDLLL-PNSHFLRYQNASRGATPGHVVTTFTKTE- 132
            .....:..:.|::.......|:.:::.||:...|| |:.....|      :..|..:|  ||.|
Human    64 EKHGKEERYEPEVQYQMILNGEEIILSLQKTKHLLGPDYTETLY------SPRGEEIT--TKPEN 120

  Fly   133 VDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDH--YLLKQADMH 195
            ::.|:|:|:|..:..||.::||||| |.|......|.|.|.|.   :...:.:|  :...|.:..
Human   121 MEHCYYKGNILNEKNSVASISTCDG-LRGYFTHHHQRYQIKPL---KSTDEKEHAVFTSNQEEQD 181

  Fly   196 PTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDSSQLIRGP 260
            |.|.|||           .:..||..|        |:|:     ||:|     ::.:....:|.
Human   182 PANHTCG-----------VKSTDGKQG--------PIRI-----SRSL-----KSPEKEDFLRA- 216

  Fly   261 YNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNESN 325
                  ..|::|.:|:||..|||:.||...:..:...:.|::|.:|..:::.|||||:.||::.:
Human   217 ------QKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTIDVQVALVGMEIWSDGD 275

  Fly   326 EIEFSSDGDLTLRNFLNYRSTKL---VLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGV 387
            :|:.......|..|||.:.|:.|   :.||    ||||:..:|....||.|....:|:......:
Human   276 KIKVVPSASTTFDNFLRWHSSNLGKKIHDH----AQLLSGISFNNRRVGLAASNSLCSPSSVAVI 336

  Fly   388 SMQHSPNPAMVATTMAHEMGHNFGMEHDTSDCHCRDEKCVMAASSTSFIPVNWS-SCSIDQLTIA 451
            ..:...|.|:|. .|:||:||..||.....:..|....|||....:|..|.::| ||...
Human   337 EAKKKNNVALVG-VMSHELGHVLGMPDVPFNTKCPSGSCVMNQYLSSKFPKDFSTSCRAH----- 395

  Fly   452 FSRGMNYCLRNKPERLFE---------SPTCGNGFVEPGEQCDCGLPEHCENACCNAQTCMLHSK 507
            |.|   |.|..||:.|.:         :|.|||..:|.||.||||.|:.|.|.||.|.||.|  |
Human   396 FER---YLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSPKECTNLCCEALTCKL--K 455

  Fly   508 NATCATGECCDLTT 521
            ..|...|:..:.||
Human   456 PGTDCGGDAPNHTT 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	30/111 (27%)
		Reprolysin	269..464	CDD:279729	61/198 (31%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	61/196 (31%)
		Disintegrin	479..555	CDD:278623	21/43 (49%)
		ACR	558..701	CDD:214743
ADAMDEC1	NP_055294.1	Pep_M12B_propep	54..172	CDD:279848	34/129 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	173..200		10/45 (22%)
		Reprolysin	218..412	CDD:279729	64/206 (31%)
		ZnMc_adamalysin_II_like	218..409	CDD:239797	63/203 (31%)
		Disintegrin	429..>461	CDD:299186	18/33 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920