DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meltrin and mde10

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_593472.1	Gene:	mde10 / 2542178	PomBaseID:	SPAC17A5.04c	Length:	512	Species:	Schizosaccharomyces pombe

Alignment Length:	244	Identity:	85/244 - (34%)
Similarity:	121/244 - (49%)	Gaps:	43/244 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 PNPAMVATTMAHEMGHNFGMEHDTSDCHCRDEK---CVMAAS--------------STSFIPVNW 440
            ||..:|   :|||:||..|:.||.:...|.|..   |.:::|              |.::..:.:
pombe   221 PNDRLV---VAHEIGHILGLIHDCNKKSCGDHSEACCPLSSSLCDAQELYIMNPSNSYTYANLRF 282

  Fly   441 SSCSIDQL-TIAFSRGMNYCLRNKP--ERLFESPTCGNGFVEPGEQCDCGLPEHCE-NACCNAQT 501
            |.|||.|| ::...:.::....:||  :.:....|||||.||.||:||||  |.|| |.||:.:|
pombe   283 SDCSILQLHSLVEKKYVSLSCLSKPSEKSVLRLGTCGNGIVEDGEECDCG--EDCENNPCCDGKT 345

  Fly   502 CMLHSKNATCATGE--CCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCD 564
            |.| :|.:.|...:  ||  ..|..|.||:.||::.|.||.||:|||.|..||.|....|...|.
pombe   346 CKL-TKGSLCDDQQDACC--YQCHFKNAGTLCRQSTNPCDKPEFCTGISSKCPVDENWDDGRICQ 407

  Fly   565 G--GQAYCFHGTCRSHSNQCRTLWGPTGDNSEHCYN-------KNTEGT 604
            .  |...|..|.|.|.|.||:.|   |..:|..|::       :|.:||
pombe   408 DSLGMGSCASGVCTSASRQCKKL---TNFSSLSCHSDSCKVSCQNEDGT 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848
		Reprolysin	269..464	CDD:279729	22/88 (25%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	22/86 (26%)
		Disintegrin	479..555	CDD:278623	37/78 (47%)
		ACR	558..701	CDD:214743	17/56 (30%)
mde10	NP_593472.1	ZnMc	65..305	CDD:294052	22/86 (26%)
mde10	NP_593472.1	Disintegrin	324..397	CDD:278623	37/77 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000154
OrthoInspector	1	1.000	-	-		otm47294
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11905
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X50
TreeFam	0	0.000	Not matched by this tool.
	7	7.030