DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meltrin and ADAM2

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001455.3	Gene:	ADAM2 / 2515	HGNCID:	198	Length:	735	Species:	Homo sapiens

Alignment Length:	746	Identity:	205/746 - (27%)
Similarity:	326/746 - (43%)	Gaps:	124/746 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 DGLHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTKTEVDLCHYQ 139
            :|:.: |.|.....|||...|:|.:.:.|..|  |..|..:..|     ::....:...:.||||
Human    39 EGIES-QASYKIVIEGKPYTVNLMQKNFLPHN--FRVYSYSGTG-----IMKPLDQDFQNFCHYQ 95

  Fly   140 GHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLL----KQADMHPTNAT 200
            |:|.|.|:|||.:|||.| |.|::.....:|.|.|.....|   .:|.:.    |:||:
Human    96 GYIEGYPKSVVMVSTCTG-LRGVLQFENVSYGIEPLESSVG---FEHVIYQVKHKKADV------ 150

  Fly   201 CGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDSSQLIRGPYNANK 265
             ...|.:|..|.|                |..:|...|         .|.|
Human   151 -SLYNEKDIESRD----------------LSFKLQSVE---------PQQD-------------- 175

  Fly   266 YSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNESNEIEFS 330
            ::.|:|:.::|:.::|.:...:|..|.|....:..:.||::|..||.:.|..:.:|.:.|:|..:
Human   176 FAKYIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATT 240

  Fly   331 SDGDLTLRNFLNYRSTKLVLDHPNDNAQLLT---KENFAGGVVGKALKGPICTYEYSGGVSMQHS 392
            .:.:..|..||.::::.||| .|:|.|.||.   |.|:    ||...:|.:|...|:|||.: |.
Human   241 GEANELLHTFLRWKTSYLVL-RPHDVAFLLVYREKSNY----VGATFQGKMCDANYAGGVVL-HP 299

  Fly   393 PNPAM--VATTMAHEMGHNFGMEH-DTSDCHCRDEKCVMAASSTSFIPVN-WSSCSIDQLTIAFS 453
            ...::  :|..:|..:..:.|:.: |.:.|.|....|:|...:..|..|. :|:||.:......|
Human   300 RTISLESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFIS 364

  Fly   454 RGMNYCLRNKP--ERLF-ESPTCGNGFVEPGEQCDCGLPEHCE---NACCNAQTCMLHSKNATCA 512
            :..:.||.|:|  :..| :...|||..:|.||:||||..:.|.   ..||:..||...: .:.||
Human   365 KQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKA-GSNCA 428

  Fly   513 TGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRS 577
            .|.||:  .|........||.:..||||||||.|.|..||.:.:.:...||...|..|..|.|.|
Human   429 EGPCCE--NCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMS 491

  Fly   578 HSNQCRTLWGPTGD-NSEHCYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERL 640
            ...||...:|...: ....||:. |::....||||.:  :..:.:||..::.||.|.|.::.:.|
Human   492 GDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGIS--DSGYTQCEADNLQCGKLICKYVGKFL 554

  Fly   641 EFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPG--LTPNGAKCGVDKMCVDQRCLPVDA 703
             ..:..|.::..:...|     .|  ..|:......|..  ...:|..||.:|:|.:|||
Human   555 -LQIPRATIIYANISGH-----LC--IAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRC----- 606

  Fly   704 VRQKGMGKPCPED-CNGNGICNSRGHCHCDVGFGGESCSKAGS---GGSPDSG-------PATDP 757
            |....:|..|..| ||..|:||::.||||...:....||....   |||.|||       ||..|
Human   607 VSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLP 671

  Fly   758 ----------NGSVGFKRFLYVLFFFVLPVV 778
                      :..:.:..||::.||.:..|:
Human   672 ERRYIENIYHSKPMRWPFFLFIPFFIIFCVL 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	32/98 (33%)
		Reprolysin	269..464	CDD:279729	55/201 (27%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	54/199 (27%)
		Disintegrin	479..555	CDD:278623	32/78 (41%)
		ACR	558..701	CDD:214743	37/146 (25%)
ADAM2	NP_001455.3	Pep_M12B_propep	42..140	CDD:279848	34/109 (31%)
		Reprolysin	178..375	CDD:279729	55/202 (27%)
		ZnMc_adamalysin_II_like	178..373	CDD:239797	54/200 (27%)
		DISIN	393..470	CDD:214490	32/79 (41%)
		ACR	472..609	CDD:214743	38/151 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920