DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meltrin and Adam29

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_787953.2	Gene:	Adam29 / 244486	MGIID:	2676326	Length:	763	Species:	Mus musculus

Alignment Length:	849	Identity:	231/849 - (27%)
Similarity:	355/849 - (41%)	Gaps:	172/849 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 DATDGLHTPQ-ISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTKTEVDL 135
            :.|.|::.|. ||.|....|:|.::.::..:|.|...                 :..||.::.|.
Mouse    50 EKTRGMNLPNWISYSLKLGGQRYIIHMKIKNLFLTRH-----------------LPVFTYSDQDS 97

  Fly   136 -----------CHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLL 189
                       |:|||::.|..||:|:||:|.|...|::......|.|.|....|   :.:| |:
Mouse    98 LLEDYPFVQDDCYYQGYVEGDSESLVSLSSCFGGFHGLLEINNIVYEIMPKKFSR---KFEH-LV 158

  Fly   190 KQADMHPT----------NATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLL 244
            .:.|.:.|          |.||..:..:                 .|.|.|
Mouse   159 YKVDSNKTESRGSSLMQDNITCQVELQK-----------------SGNPIL-------------- 192

  Fly   245 RKRRQADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPL 309
             |:...:|..          .::..||||:|||..:|.::...|..:.. ...:.||::.:|..:
Mouse   193 -KQSSFEDWW----------THTKIVELVVVVDKTLYDHYGNYTVMLSD-LYSVINIVDTIYEVI 245

  Fly   310 NIFVALVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKAL 374
            .|.:.||||.:||:.|.|.. .|...:||.:..::::..:....:|.:.|....:.. |:.|...
Mouse   246 GIKILLVGVEVWNKKNLIVI-DDVSKSLRLYCRWKASNFLHRLKHDVSHLFIYRHLR-GLSGIGS 308

  Fly   375 KGPICTYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSDCHCRDEKCVMAASSTSFIPVN 439
            .|.||..:.|..|.........:.|..:||.:|||.||:||...|.|...||:|...|.. || .
Mouse   309 TGGICDPKRSCAVVTFIDRTLNLRAIGVAHHLGHNLGMKHDEDICKCSYSKCIMHMDSPP-IP-K 371

  Fly   440 WSSCSID---QLTIAFSRGMNYCLRNK--PERLFESPTCGNGFVEPGEQCDCGLPEHCENACCNA 499
            :|:||.:   ..|:..:|    ||...  .:.:|:...||||.||..||||||...:|.|..|..
Mouse   372 FSNCSYNYFWSYTVKNTR----CLMENMYTKDIFDRTRCGNGVVEDKEQCDCGSLRNCTNDLCCM 432

  Fly   500 QTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCD 564
            ..|.| |..::||.|.||  ..|:...:|:.||:.:|.|||||:|.|.|..||.|.:..|..||
Mouse   433 SNCTL-STGSSCAFGLCC--KNCQFLPSGTLCRKRDNICDLPEWCNGTSHECPDDAYVEDGIPC- 493

  Fly   565 GGQAYCFHGTCRSHSNQCRTLWGPTGDN-SEHCYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVN 627
            |..|||:...|...:..||.::|..... |.|||.: ||:|.|.|:||..  ..|:::|:.....
Mouse   494 GVSAYCYEKQCNDRNEHCRQIFGQNAKTASVHCYREINTKGDRFGHCGLQ--GPTYIKCKSNDAL 556

  Fly   628 CGMLHCIHLNERLEFGMESAAVLSHSYISHDR-KIVACRTALVDLGLQTTDPGLTPNGAKCGVDK 691
            ||.:.|.::       ::...:..||.|.... |.|:|.......|...||.|...:|.:|..:.
Mouse   557 CGRIQCDNV-------VQIPNMKDHSTIHFALVKNVSCWGTDYHTGTSLTDIGDVKDGTECEQNH 614

  Fly   692 MCVDQRCLPVDAVRQKGMGKPC-PEDCNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSG--P 753
            :|:::.|:.:..     :...| |..||..||||::.||||:..:...:|...|.|||.|||  |
Mouse   615 ICINRHCVHIST-----LDSNCTPAFCNYRGICNNKHHCHCNFHWDPPNCMIRGHGGSVDSGLPP 674

  Fly   754 ATDPNGSVGFKRFLYVLFFFVLPVV----ALFWFLYHCYKNGMLTRGKLADNILKSSGGSKPITT 814
            .|:..     |.|.|:|...::.:.    .|.|.|:               ||    .|||
Mouse   675 KTNKK-----KHFFYLLLLQLIILACLLSCLLWLLF---------------NI----KGSK---- 711

  Fly   815 RTNQNGTGPPPSNGLLKSTPSSTDDMDSALLKSPSDSTPSAGLFGKFDGFTLRPLNDASSPASNY 879
            |..|....|..:..:.|..||....      ..||.|.|.           ||..:.::||.|:.
Mouse   712 RKPQVQPTPVKTKKVSKKVPSQKPS------PVPSPSLPQ-----------LRMPSRSASPTSSI 759

  Fly   880 NGPN 883
            ...|
Mouse   760 KSTN 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	28/113 (25%)
		Reprolysin	269..464	CDD:279729	58/199 (29%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	58/195 (30%)
		Disintegrin	479..555	CDD:278623	33/75 (44%)
		ACR	558..701	CDD:214743	41/145 (28%)
Adam29	NP_787953.2	Pep_M12B_propep	58..158	CDD:279848	29/120 (24%)
		Reprolysin	205..391	CDD:279729	56/194 (29%)
		ZnMc_adamalysin_II_like	205..391	CDD:239797	56/194 (29%)
		Disintegrin	412..484	CDD:278623	33/74 (45%)
		ACR	489..624	CDD:214743	41/144 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	712..763		15/67 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0000154
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920