Protein Alignment Meltrin and Adam23

DIOPT Version :9

• Sequence 1: NP_001027575.1
• Gene: Meltrin / 3772109
• FlyBaseID: FBgn0265140
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: NP_035910.1
• Gene: Adam23 / 23792
• MGIID: 1345162
• Length: 829
• Species: Mus musculus
• Alignment Length: 777
• Identity: 223/777 - (28%)
• Similarity: 351/777 - (45%)
• Gaps: 133/777 - (17%)

  Fly    15 NTCLQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRTKRSLLTTLDATDGLHT 79
            ::.:|:.|..|:. ..::.::..:|..| ||:     |..|.|.:|.:             .:|.
Mouse   101 SSAVQKEITLPSR-LVYYINQDSESPYH-VLD-----TKARHQQKHNK-------------AVHL 145

  Fly    80 PQISLSYTHEGKRVVVDLQRNDLLLPNSHF-LRYQNASRGATPGHVVTTFTKTEVDLCHYQGHIR 143
            .|.|......|.:.::||..|:.||.:.:. :.|::..:..:.|.          :.|:|.|.||
Mouse   146 AQASFQIEAFGSKFILDLTLNNGLLSSDYVEIHYEDGKQMYSKGG----------EHCYYHGSIR 200

  Fly   144 GKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTNATCGYDNHRD 208
            |..:|.||||||:| |.|:..|....|.|.|.     .|.||
Mouse   201 GVKDSRVALSTCNG-LHGMFEDDTFVYMIEPL-----ELTDD----------------------- 236

  Fly   209 DHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTL-------------------LRKRRQADDSS 254
                  ||:.|.       |.:..:...|::|:.:                   ||:|::|.:.|
Mouse   237 ------EKSTGR-------PHIIQKTLAGQYSKQMKNLSTDGSDQWPLLPELQWLRRRKRAVNPS 288

  Fly   255 QLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALY-VPLNIFVALVGV 318
               ||.:...|   |:||:||.|:|.||..:.:....:.:.|.:.|:::::| ..||..|.||.|
Mouse   289 ---RGVFEEMK---YLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAV 347

  Fly   319 VIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEY 383
            ..|.|.:.|:.:.:....|.:|..||  :.:..|. |...|:::..|.......:..|.:|:  .
Mouse   348 ETWTEKDHIDITINPVQMLHDFSKYR--QRIKQHA-DAVHLISRVTFHYKRSSLSYFGGVCS--R 407

  Fly   384 SGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSD----CHCRDE--KCVMAASSTSFIPVNWSS 442
            ..||.:.....|..||..::..:..|.|::.:.|.    |.|.:.  .|:|..:..|. ...:|.
Mouse   408 IRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPSSRKPKCECIESWGGCIMEETGVSH-SRKFSK 471

  Fly   443 CSIDQLTIAFSRGMNYCLRNKPERLFESPTCGNGFVEPGEQCDCGLPEHCENACCNAQTCMLHSK 507
            |||.:......||...||.|:|.:|||...||||:||.||:||||....|...||  :.|.| |.
Mouse   472 CSILEYRDFLQRGGGACLFNRPTKLFEPTECGNGYVEAGEECDCGFHVECYGVCC--KKCSL-SN 533

  Fly   508 NATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFH 572
            .|.|:.|.||:.|:|..:..|..||:|.|.||:.|||||:|..||.::.::|...|:..|..|::
Mouse   534 GAHCSDGPCCNNTSCLFQSRGYECRDAVNSCDITEYCTGDSGQCPPNLHKQDGYSCNQNQGRCYN 598

  Fly   573 GTCRSHSNQCRTLWGPTGDNSE-HCYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIH 635
            |.|::..|||:.:||.....|: .||.| |||||..||||.:  ...::.|.:..|.||.|.|.:
Mouse   599 GECKTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKD--GDRWIPCSKHDVFCGFLLCTN 661

  Fly   636 LNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLP 700
            |......|.....::..|:. |..:::.|..|.|.|. ..||.|...:|..||...||:|::||.
Mouse   662 LTRAPRIGQLQGEIIPTSFY-HQGRVIDCSGAHVVLD-DDTDVGYVEDGTPCGPSMMCLDRKCLQ 724

  Fly   701 VDAVRQKGMGKPCPED-----CNGNGICNSRGHCHCDVGFGGESCSKAGSGGSP----DSGP 753
            :.|:....    ||.|     |:|:|:|::...|.||..:.|..||......:|    |.||
Mouse   725 IQALNMSS----CPLDSRGKVCSGHGVCSNEATCICDFTWAGTDCSIRDPVRNPNPPKDEGP 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	30/110 (27%)
		Reprolysin	269..464	CDD:279729	53/201 (26%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	52/199 (26%)
		Disintegrin	479..555	CDD:278623	35/75 (47%)
		ACR	558..701	CDD:214743	49/144 (34%)
Adam23	NP_035910.1	Pep_M12B_propep	144..246	CDD:279848	38/153 (25%)
		Reprolysin	296..493	CDD:279729	54/205 (26%)
		ZnMc_adamalysin_II_like	296..491	CDD:239797	53/203 (26%)
		Disintegrin	508..581	CDD:278623	35/75 (47%)
		ACR	584..723	CDD:214743	47/142 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020