DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and Gm4787

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001034084.2	Gene:	Gm4787 / 214321	MGIID:	3646380	Length:	748	Species:	Mus musculus

Alignment Length:	812	Identity:	215/812 - (26%)
Similarity:	335/812 - (41%)	Gaps:	157/812 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 FSTYTVIRPQVEHGRTKRSLLTTLDATDGLHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLRY 112
            |||..::.|:....|..:|.:          :..|:.|....|:|.||.::....::| .:|..|
Mouse    42 FSTSEIVIPRKVPQRMGKSDM----------SGHITYSMRFRGQRHVVHMKLKKNMIP-QNFPVY 95

  Fly   113 QNASRGATPGHVVTTFTKTEVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHID 177
            .:..:||.....  .|...:   |::..::.|.|.|...|.||.|.|.|::.....||.|.| :.
Mouse    96 TSNDQGAQQKDY--PFVPRD---CYFYSYLEGVPGSQATLDTCTGGLKGMIQVDDFTYEIKP-LA 154

  Fly   178 GRGRLQDDHYLLKQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLG--GGIPSLPLRLDGGEFS 240
            ...:.:....||..                |:.|.:.:|...|..:.  |.:|
Mouse   155 SSSKFEHVISLLVV----------------DERSRESKKCRNDEIMAKVGNLP------------ 191

  Fly   241 RTLLRKRRQADDSSQLIRGPYNANKY-----SSYVELVIVVDNKVYKNFQENTKKVHQYCKGIAN 300
                       :.::|...|..|..|     |..|.:...|.:::|.....|:....:....:.:
Mouse   192 -----------EETKLAGSPRAAPVYLWRYHSKNVGIQYTVTHELYTQIGSNSTASIELILIMTS 245

  Fly   301 IINALYVPLNIFVALVGVVIWNESNEIEFSSDGDLTLRNFLN--YRSTKLV----------LDHP 353
            |.:::|....:||......|||:.:....||        |.|  :|..:|.          ::|.
Mouse   246 ISHSIYKTSGMFVFARAACIWNDKDHYSISS--------FYNNVWRLMELFGYWKAGYFWHMEHA 302

  Fly   354 NDNAQLLTKE----NFAGGVVGKALKGPICT------YEYSGGVSMQHSPNPAMVATTMAHEMGH 408
            . .|.||.::    ::||      .:..||.      |.|.|      :.:..:..:.:||.:||
Mouse   303 T-TALLLGRKLGNTDYAG------FQDGICNPNWGVLYTYVG------TNHFFLAGSFLAHAVGH 354

  Fly   409 NFGMEHDTSDCHC-RDEKCVMAASSTSFIPVNWSSCSIDQLTIAFSRGMNYCLR--NKPERLFES 470
            ...:.|||..|.| |...|:|....|  :....|:||.|.|.:.. .|.:.|:.  .:...:...
Mouse   355 LLNVRHDTPGCVCFRRSSCLMDEFPT--LQDMISNCSHDVLHMRI-HGWDPCMSEVRRTHNIQNV 416

  Fly   471 PTCGNGFVEPGEQCDCGLPEHC-ENACCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREA 534
            |.|||..||..|.||||..:.| .:.||... |.. ::.::|..|.||  .:|:....|:.||:.
Mouse   417 PRCGNKIVEGSESCDCGSVKDCTTDKCCEVD-CEF-TQGSSCNKGGCC--LSCKFAPTGTICRDK 477

  Fly   535 ENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWG-PTGDNSEHCYN 598
            ...|||||||:|.||:||.:.:..|..|| ...|.|..|.|.....||:.|:| ...|:|..||:
Mouse   478 NGICDLPEYCSGASEHCPGNFYIMDGTPC-SPLAVCIAGNCTDRHLQCQALFGYQVKDSSPACYH 541

  Fly   599 K-NTEGTRLGNCG--YNRLNKTFLRCEEQHVNCGMLHCIHLNERLEFGMESAAVLSHSYISH--- 657
            : |.:|.|.||||  ..|.....:.|:::.|.||||||..: :|:..|.|      |:...|
Mouse   542 ELNVKGDRFGNCGVRIKRGGSQTVPCQKEDVFCGMLHCDGV-KRIVGGGE------HTTFYHLKV 599

  Fly   658 -DRKIVACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPVDAVRQKGMGKPCP-EDCNGN 720
             |.|.|.|....:..||...:.||..:||.||..|.|.:|||     |..:.:...|. ..||..
Mouse   600 QDVKEVQCFGYDIHHGLDLPEIGLVMDGATCGPGKYCKNQRC-----VFHQTLKFNCNISSCNFR 659

  Fly   721 GICNSRGHCHCDVGFGGESCSKAGSGGSPDSGPATDP------NGSVGFKRFLYVLFFFVLPVVA 779
            |:||::|:|||..|:....|.:.|.|||.:|||.|:|      ...|...:.|.:|...:..:||
Mouse   660 GVCNNQGNCHCVQGWQPPKCLQRGKGGSVNSGPITNPLKRYRAKIHVSINKLLIILGARIFLIVA 724

  Fly   780 LFWFLYHCYKNGMLTRGKLADNILKSSGGSKP 811
            |..|            |.||..:|:.....:|
Mouse   725 LIIF------------GALAKAVLRPEVPQRP 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	26/109 (24%)
		Reprolysin	269..464	CDD:279729	48/219 (22%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	48/217 (22%)
		Disintegrin	479..555	CDD:278623	30/76 (39%)
		ACR	558..701	CDD:214743	53/150 (35%)
Gm4787	NP_001034084.2	Pep_M12B_propep	60..163	CDD:279848	27/119 (23%)
		ZnMc_adamalysin_II_like	213..405	CDD:239797	48/215 (22%)
		Disintegrin	425..498	CDD:278623	30/76 (39%)
		ACR	501..642	CDD:214743	53/153 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920