DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and ADAM32

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_659441.4	Gene:	ADAM32 / 203102	HGNCID:	15479	Length:	787	Species:	Homo sapiens

Alignment Length:	924	Identity:	228/924 - (24%)
Similarity:	376/924 - (40%)	Gaps:	186/924 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LFLLPLLLLNTC--------LQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGR 62
            :|.|.|||...|        .|..:||..                 :.|:..|.|....::|:
Human     1 MFRLWLLLAGLCGLLASRPGFQNSLLQIV-----------------IPEKIQTNTNDSSEIEY-- 46

  Fly    63 TKRSLLTTLDATDGLHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTT 127
                             .|||.....:.|...|.|::...|..|.....|...|        :.|
Human    47 -----------------EQISYIIPIDEKLYTVHLKQRYFLADNFMIYLYNQGS--------MNT 86

  Fly   128 FTKTEVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQA 192
            ::......|:|||:|.|.|:|:|.||||.| |.||:.....:|.|.| ::.....|...|.||..
Human    87 YSSDIQTQCYYQGNIEGYPDSMVTLSTCSG-LRGILQFENVSYGIEP-LESAVEFQHVLYKLKNE 149

  Fly   193 DMHPTNATCGY------DNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQAD 251
            |    |....:      :...||:....||::         |::|
Human   150 D----NDIAIFIDRSLKEQPMDDNIFISEKSE---------PAVP-------------------- 181

  Fly   252 DSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALV 316
                        :.:..|:|:.||||..:|..:..::..|......|..:.|:::....:.:.|.
Human   182 ------------DLFPLYLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLS 234

  Fly   317 GVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTY 381
            .:.:|::.|:|....:.|..|:.||.::.:.|.| .|:|.|.||...::. ..:|....|.:|..
Human   235 SLELWSDENKISTVGEADELLQKFLEWKQSYLNL-RPHDIAYLLIYMDYP-RYLGAVFPGTMCIT 297

  Fly   382 EYSGGVSMQHSPNP------AMVATTM-AHEMGHNFGMEHDTSDCHCRDEKCVMAASSTSFIPVN 439
            .||.||::.  |..      |::.|.| |..:|.::   .|...|.|.:..|:|   :...:..|
Human   298 RYSAGVALY--PKEITLEAFAVIVTQMLALSLGISY---DDPKKCQCSESTCIM---NPEVVQSN 354

  Fly   440 ----WSSCSIDQLTIAFSRGMNYCLRNKPERLFES--PTCGNGFVEPGEQCDCGLPEHCENA-CC 497
                :||||:.......|.....||:|||:...:|  |.||||.:|..|.||||....|..| ||
Human   355 GVKTFSSCSLRSFQNFISNVGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCC 419

  Fly   498 NAQTCMLHSKNATCATGECCDLTTCRPKLAGSACR-EAENECDLPEYCTGESEYCPADVFRRDTE 561
            :.:||:| ...|.|..|.||  ..|:...:|..|| :|..|||:.|.|.|.|..|..|:...:..
Human   420 DFRTCVL-KDGAKCYKGLCC--KDCQILQSGVECRPKAHPECDIAENCNGTSPECGPDITLINGL 481

  Fly   562 PCDGGQAYCFHGTCRSHSNQCRTLWGPTGDNSEH-CYNK-NTEGTRLGNCGYNRLNKTFLRCEEQ 624
            .|...:..|:.|.|.....:|.:::|....|:.. ||.: .::..|.||||.:|.|| ::.|..:
Human   482 SCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNK-YVFCGWR 545

  Fly   625 HVNCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTT--DPGLTPNGAKC 687
            ::.||.|.|.: ..|..|..|:..|: ::::...    .|.|  ||..|..|  ||....||::|
Human   546 NLICGRLVCTY-PTRKPFHQENGDVI-YAFVRDS----VCIT--VDYKLPRTVPDPLAVKNGSQC 602

  Fly   688 GVDKMCVDQRCLPVDAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGFGGESCSKAGSGGS--PD 750
            .:.::||::.|  |::...|.....|.:.|:|:|:|:||..|||..|:...:|.....|.|  |:
Human   603 DIGRVCVNREC--VESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPE 665

  Fly   751 SGPATDPNGSVGFKRFLYVL-FFFVLPVVALF------------WFLYHCYKNGMLTRGKLADNI 802
            ....:....:.|.....::| |...||::.:.            ||         ....:...:.
Human   666 EDMGSIMERASGKTENTWLLGFLIALPILIVTTAIVLARKQLKKWF---------AKEEEFPSSE 721

  Fly   803 LKSSGGSKPITTRTNQNGTGPPPSNGLLKSTPSSTDDMDSALLKSPSDSTPSAGLFGKFDGFTLR 867
            .||.|.::...::::..|:....::.....:.|..|       .|.|.|..||      :.:|.|
Human   722 SKSEGSTQTYASQSSSEGSTQTYASQTRSESSSQAD-------TSKSKSEDSA------EAYTSR 773

  Fly   868 PLN-DASSPASNYN 880
            ..: |::...|:.|
Human   774 SKSQDSTQTQSSSN 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	30/109 (28%)
		Reprolysin	269..464	CDD:279729	52/205 (25%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	51/203 (25%)
		Disintegrin	479..555	CDD:278623	31/77 (40%)
		ACR	558..701	CDD:214743	40/146 (27%)
ADAM32	NP_659441.4	Pep_M12B_propep	27..144	CDD:307618	37/162 (23%)
		Reprolysin	187..383	CDD:307535	52/205 (25%)
		Disintegrin	400..474	CDD:306668	31/76 (41%)
		ADAM_CR	479..593	CDD:312126	32/122 (26%)
		SEEEED	<714..>786	CDD:317234	15/84 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..787		15/84 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920