DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meltrin and Adam6

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_620261.1	Gene:	Adam6 / 192271	RGDID:	621472	Length:	751	Species:	Rattus norvegicus

Alignment Length:	835	Identity:	215/835 - (25%)
Similarity:	356/835 - (42%)	Gaps:	171/835 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LHLFLLPLLLLNTCLQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVI-RPQVEHGRTKRSL 67
            |.||.|.|||         |.|...     |||     ||.....|:..|| |.::.|.:
  Rat    21 LLLFALWLLL---------LVPVRC-----SEG-----HPTWRYISSEVVIPRKEIYHSK----- 61

  Fly    68 LTTLDATDGLHTP-QISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTKT 131
                    |:.|. ::|.|....|:|.::.|:|..|:.|. |.|......:||    :...:...
  Rat    62 --------GIQTQGRLSYSLRFRGQRHIIHLRRKTLIWPR-HLLLTTQDDQGA----LQMDYPFF 113

  Fly   132 EVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQADM-H 195
            .|| |:|.|::.|.|:|:|.::||.|.|:||::.....|.|.|..|.:|.......::.:.|: .
  Rat   114 PVD-CYYFGYLEGIPQSMVTVNTCYGGLEGIMMLDDLAYEIKPLNDSQGFEHIVSQIVSEPDVTG 177

  Fly   196 PTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDSSQLIRGP 260
            |||.              :::.:.:.|     |.|         |||     ..|:.:.::
  Rat   178 PTNT--------------WKRLNLNTG-----PPL---------SRT-----EYANGTPRM---- 205

  Fly   261 YNANKYSSYVELV---IVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVGVVIWN 322
             ::..|:|:...:   ....|.:||. ..|.....:|...:.:|.::..:.:::....:.:.::.
  Rat   206 -SSKNYASHPAAIKGQFQATNSIYKE-SNNIDTAARYLFELLSITDSFLITIHMRYYAILLTVFT 268

  Fly   323 ESN--EIEFSSDG----DLTLRNFLNY----RSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGP 377
            ||:  .:|::..|    :..:.||.|.    .||.|..|.|:||       :|      ..::..
  Rat   269 ESDPFALEYTVPGGSIYNYYVSNFFNRLRPDASTVLNKDGPSDN-------DF------HPVEQS 320

  Fly   378 ICTYEYSGGVSM--QHSPNPAMVATTMAHEMGHNFGMEHDTSD---CHCRDEKCVMAASSTSFIP 437
            :||   ..|:::  ||..:...::..:.:.:..:.|::.|...   || |...|:|..:..  |.
  Rat   321 LCT---PAGLTIVGQHRRSFLALSVMITNRIAMSLGIKADDETYCICH-RRTTCIMYKNPE--IT 379

  Fly   438 VNWSSCSIDQLT-IAFSRGMNYCLRNKPERLFESPT-----CGNGFVEPGEQCDCGLPEHC-ENA 495
            ..:|:||:.|:. |..:.|...|| .....::.:.|     |||..::.|||||||..:.| .:.
  Rat   380 DAFSNCSLVQINQILNTPGTMSCL-FYDHHVYHNITKTYRFCGNFKIDIGEQCDCGSHKACYADP 443

  Fly   496 CCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDT 560
            ||.: .|.| :..:.|....||...|..|  :|:.||..:|.|||||||:|.:.:||||.:.:|.
  Rat   444 CCGS-NCKL-TAGSICDKELCCANCTYSP--SGTLCRPIQNICDLPEYCSGNNIFCPADTYLQDG 504

  Fly   561 EPCDGGQAYCFHGTCRSHSNQCRTLWGPTGDNSE-HCYNKNTEGTRLGNCGYNRLNKTFLRCEEQ 624
            .|| ..:.||:.|.|...|.||:.::|.....:. .||:.|.:..|.|:|...:.:..|..|.:.
  Rat   505 TPC-SEEGYCYKGNCTDRSVQCKEIFGMNAKGANIKCYDINKQRFRFGHCTRAQESLMFNACSDH 568

  Fly   625 HVNCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKIVACRTAL-VD--LGLQTTDPGLTPNGAK 686
            ...||.|.|.::. .|.|..|        ::|..:.:::..|.. :|  .|.:|||.||..:|..
  Rat   569 DKLCGRLQCTNVT-NLPFLQE--------HVSFHQSVISGFTCFGLDEHRGTETTDAGLVKHGTP 624

  Fly   687 CGVDKMCVDQRC------LPVDAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGFGGESCSKAGS 745
            |.....|....|      |..|..         ||.||..|:||:..||||.:|:....|.:.|.
  Rat   625 CSQTNFCDRGACNGSLSRLDYDCT---------PEKCNFRGVCNNHRHCHCHLGWKPPLCREEGP 680

  Fly   746 GGSPDSGPATDPNGSVGFKR--FLYVLFFF---VLPVVALFWFLYHCYKNGMLTR 795
            .||.|||.......::...|  .||:...|   .|.:|:|.:        |:.||
  Rat   681 SGSTDSGSPPKERRTIKQSREPLLYLRMLFGRLYLFIVSLLF--------GVATR 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	31/110 (28%)
		Reprolysin	269..464	CDD:279729	42/213 (20%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	42/211 (20%)
		Disintegrin	479..555	CDD:278623	32/76 (42%)
		ACR	558..701	CDD:214743	40/152 (26%)
Adam6	NP_620261.1	Pep_M12B_propep	64..166	CDD:279848	33/107 (31%)
		ZnMc_adamalysin_II_like	217..405	CDD:239797	42/208 (20%)
		Disintegrin	428..499	CDD:278623	32/74 (43%)
		ACR	502..637	CDD:214743	38/144 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.010