Protein Alignment Meltrin and Adam6

DIOPT Version :10

• Sequence 1: NP_001027575.1
• Gene: Meltrin / 3772109
• FlyBaseID: FBgn0265140
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: NP_620261.1
• Gene: Adam6 / 192271
• RGDID: 621472
• Length: 751
• Species: Rattus norvegicus
• Alignment Length: 835
• Identity: 215/835 - (25%)
• Similarity: 356/835 - (42%)
• Gaps: 171/835 - (20%)

  Fly     4 LHLFLLPLLLLNTCLQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVI-RPQVEHGRTKRSL 67
            |.||.|.|||         |.|...     |||     ||.....|:..|| |.::.|.:
  Rat    21 LLLFALWLLL---------LVPVRC-----SEG-----HPTWRYISSEVVIPRKEIYHSK----- 61

  Fly    68 LTTLDATDGLHTP-QISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTKT 131
                    |:.|. ::|.|....|:|.::.|:|..|:.|. |.|......:||    :...:...
  Rat    62 --------GIQTQGRLSYSLRFRGQRHIIHLRRKTLIWPR-HLLLTTQDDQGA----LQMDYPFF 113

  Fly   132 EVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQADM-H 195
            .|| |:|.|::.|.|:|:|.::||.|.|:||::.....|.|.|..|.:|.......::.:.|: .
  Rat   114 PVD-CYYFGYLEGIPQSMVTVNTCYGGLEGIMMLDDLAYEIKPLNDSQGFEHIVSQIVSEPDVTG 177

  Fly   196 PTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDSSQLIRGP 260
            |||.              :::.:.:.|     |.|         |||     ..|:.:.::
  Rat   178 PTNT--------------WKRLNLNTG-----PPL---------SRT-----EYANGTPRM---- 205

  Fly   261 YNANKYSSYVELV---IVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVGVVIWN 322
             ::..|:|:...:   ....|.:||. ..|.....:|...:.:|.::..:.:::....:.:.::.
  Rat   206 -SSKNYASHPAAIKGQFQATNSIYKE-SNNIDTAARYLFELLSITDSFLITIHMRYYAILLTVFT 268

  Fly   323 ESN--EIEFSSDG----DLTLRNFLNY----RSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGP 377
            ||:  .:|::..|    :..:.||.|.    .||.|..|.|:||       :|      ..::..
  Rat   269 ESDPFALEYTVPGGSIYNYYVSNFFNRLRPDASTVLNKDGPSDN-------DF------HPVEQS 320

  Fly   378 ICTYEYSGGVSM--QHSPNPAMVATTMAHEMGHNFGMEHDTSD---CHCRDEKCVMAASSTSFIP 437
            :||   ..|:::  ||..:...::..:.:.:..:.|::.|...   || |...|:|..:..  |.
  Rat   321 LCT---PAGLTIVGQHRRSFLALSVMITNRIAMSLGIKADDETYCICH-RRTTCIMYKNPE--IT 379

  Fly   438 VNWSSCSIDQLT-IAFSRGMNYCLRNKPERLFESPT-----CGNGFVEPGEQCDCGLPEHC-ENA 495
            ..:|:||:.|:. |..:.|...|| .....::.:.|     |||..::.|||||||..:.| .:.
  Rat   380 DAFSNCSLVQINQILNTPGTMSCL-FYDHHVYHNITKTYRFCGNFKIDIGEQCDCGSHKACYADP 443

  Fly   496 CCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDT 560
            ||.: .|.| :..:.|....||...|..|  :|:.||..:|.|||||||:|.:.:||||.:.:|.
  Rat   444 CCGS-NCKL-TAGSICDKELCCANCTYSP--SGTLCRPIQNICDLPEYCSGNNIFCPADTYLQDG 504

  Fly   561 EPCDGGQAYCFHGTCRSHSNQCRTLWGPTGDNSE-HCYNKNTEGTRLGNCGYNRLNKTFLRCEEQ 624
            .|| ..:.||:.|.|...|.||:.::|.....:. .||:.|.:..|.|:|...:.:..|..|.:.
  Rat   505 TPC-SEEGYCYKGNCTDRSVQCKEIFGMNAKGANIKCYDINKQRFRFGHCTRAQESLMFNACSDH 568

  Fly   625 HVNCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKIVACRTAL-VD--LGLQTTDPGLTPNGAK 686
            ...||.|.|.::. .|.|..|        ::|..:.:::..|.. :|  .|.:|||.||..:|..
  Rat   569 DKLCGRLQCTNVT-NLPFLQE--------HVSFHQSVISGFTCFGLDEHRGTETTDAGLVKHGTP 624

  Fly   687 CGVDKMCVDQRC------LPVDAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGFGGESCSKAGS 745
            |.....|....|      |..|..         ||.||..|:||:..||||.:|:....|.:.|.
  Rat   625 CSQTNFCDRGACNGSLSRLDYDCT---------PEKCNFRGVCNNHRHCHCHLGWKPPLCREEGP 680

  Fly   746 GGSPDSGPATDPNGSVGFKR--FLYVLFFF---VLPVVALFWFLYHCYKNGMLTR 795
            .||.|||.......::...|  .||:...|   .|.:|:|.:        |:.||
  Rat   681 SGSTDSGSPPKERRTIKQSREPLLYLRMLFGRLYLFIVSLLF--------GVATR 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	53..174	CDD:460254	35/122 (29%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	42/211 (20%)
		Disintegrin	479..554	CDD:459709	31/75 (41%)
		ACR	558..701	CDD:214743	40/152 (26%)
		PHA03247	<823..1261	CDD:223021
		PHA03247	<1220..1392	CDD:223021
Adam6	NP_620261.1	Pep_M12B_propep	49..166	CDD:460254	38/135 (28%)
		ZnMc_adamalysin_II_like	217..405	CDD:239797	42/208 (20%)
		Disintegrin	428..498	CDD:459709	31/73 (42%)
		ACR	502..637	CDD:214743	38/144 (26%)