Protein Alignment Meltrin and adm-4

DIOPT Version :9

• Sequence 1: NP_001027575.1
• Gene: Meltrin / 3772109
• FlyBaseID: FBgn0265140
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: NP_509318.1
• Gene: adm-4 / 181041
• WormBaseID: WBGene00000075
• Length: 686
• Species: Caenorhabditis elegans
• Alignment Length: 775
• Identity: 156/775 - (20%)
• Similarity: 253/775 - (32%)
• Gaps: 284/775 - (36%)

  Fly    48 FSTYTVIRPQVEHGRTKRSLLTTLDATDGLHTP--------QISLSYTHEGKRVVVDLQRNDLLL 104
            |....:::....:.|.||            |.|        |..:.:....:..||||:.|
 Worm    11 FLVLGILKSDAFNTRVKR------------HAPIRFQRSTRQSVVHFEFLDQEYVVDLEPN---- 59

  Fly   105 PNSHFLRYQNASRGATPGHVVTTFTKTEVDLC---HYQGHIRGKPESVVALSTCDGALDGIVIDG 166
               |...::|          ...||:....:.   .|.|.:| :|.:..|:.|   .|:..|..|
 Worm    60 ---HSTFHEN----------FKVFTQDGPQIVPRDEYIGTVR-EPRAGRAVLT---QLEENVYIG 107

  Fly   167 RQTYFI---------HPHIDGRGRLQDDHYLLKQADMHPTNATCGYDNHRDDHSHDYEKADGDNG 222
             ..||:         :||     :|.||           .....||             .:.|..
 Worm   108 -SLYFVDDTLHLEPSYPH-----QLSDD-----------LGPVVGY-------------FESDLD 142

  Fly   223 LGGGIPSLPLRLDGGEFSRT--LLRKRRQADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNF- 284
            |...:.::|:| :...|.|.  .|:.||.....|...:...|..:  :...|.:|.|...|..|
 Worm   143 LNLDLSAMPVR-NQVSFRRANPFLKHRRAIAIPSDRRKDVLNVKR--NRCTLKLVADYSFYSIFG 204

  Fly   285 QENTKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLV 349
            :.||..|.::...:...:|.:|.|:|          |:...|.:.|..|......| :.:..| |
 Worm   205 KNNTGIVTKFLVNMIARVNEIYTPIN----------WDVGKEDDISGRGRFQNMGF-SIKEIK-V 257

  Fly   350 LDHPN-------------DNAQLLTKENFAGG---------VVGKALK----------------- 375
            ||.||             :..:||.:..||.|         |..:..:
 Worm   258 LDRPNASDSHYNSYSRIWEVERLLREFAFAEGSKDFCLVHLVTARTFREVATLGLAYVSYKKWDE 322

  Fly   376 --GPICTYE--YSGGV------------SMQHSPNPAM---VATTMAHEMGHNFGMEH------- 414
              |.||:.:  ::|.|            :.:.|..|.:   :...::||.||.:|..|
 Worm   323 TAGGICSKQETFNGRVAYINVLLSTSFANSEQSTYPLITKEIDIVVSHEYGHAWGATHDPTIDSD 387

  Fly   415 --DTSDCHCRDE---KCVMA--------ASSTSFIPVN-----------WSSCSIDQLTIAFSRG 455
              |..:|...|:   |.:|:        |::..|.|.:           |.||..:::| :|
 Worm   388 DPDVEECSPNDQNGGKYLMSQYAQKGYDANNVLFSPCSRKLIRDVLIGKWESCFQEEMT-SF--- 448

  Fly   456 MNYCLRNKPERLFESPTCGNGFVEPGEQCDCGLPEHCENACCNAQTCMLHSKNATCA-TGECCDL 519
                             ||||.||.||:||.|:....|..||: :.|.| :..|.|: ....|..
 Worm   449 -----------------CGNGIVEDGEECDNGVDTDNEFNCCD-KFCRL-AVGAKCSPLNHICCT 494

  Fly   520 TTCRPKLAGSACREAEN-ECDLPEYCTGESEYCPADVFRRDTEPC-DGGQAYCFHGTCRSHSNQC 582
            .||:...:...|...:: .|.....|.|.|..||:....||.:.| :||:  |.:|.|
 Worm   495 PTCQFHNSTHVCLPGDSLLCKADAVCNGFSGECPSAPPVRDGQECLEGGE--CLNGVC------- 550

  Fly   583 RTLWGPTGDNSEHCYNKNTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERLEFGMESA 647
                                   |..|....:.|....||:..::|.:  |..     ::....|
 Worm   551 -----------------------LPFCEKMSIGKKSCICEDLELSCRL--CCR-----DYNGTCA 585

  Fly   648 AVLSHSYISHDRKIVACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCL--PVDAVR 705
            .|..|.|:.                          :|.:|.... |.|::|:  .||.||
 Worm   586 PVPGHVYLR--------------------------DGVRCSKGS-CRDRKCVNEVVDNVR 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	25/129 (19%)
		Reprolysin	269..464	CDD:279729	55/284 (19%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	55/282 (20%)
		Disintegrin	479..555	CDD:278623	23/77 (30%)
		ACR	558..701	CDD:214743	24/145 (17%)
adm-4	NP_509318.1	ZnMc_TACE_like	187..448	CDD:239798	54/273 (20%)
		Disintegrin	455..528	CDD:306668	21/74 (28%)
		ADAM17_MPD	552..610	CDD:271205	14/91 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.950