Protein Alignment Meltrin and Adam24

DIOPT Version :10

• Sequence 1: NP_001027575.1
• Gene: Meltrin / 3772109
• FlyBaseID: FBgn0265140
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: NP_034216.3
• Gene: Adam24 / 13526
• MGIID: 105984
• Length: 761
• Species: Mus musculus
• Alignment Length: 789
• Identity: 224/789 - (28%)
• Similarity: 344/789 - (43%)
• Gaps: 136/789 - (17%)

  Fly    82 ISLSYTHEGKRVVVDLQRNDLL----LP----NSHFLRYQNASRGATPGHVVTTFTKTEVDLCHY 138
            :|.|....|:|.::.::..:.|    ||    |...:.:::           ..|.:.:   |:|
Mouse    62 MSYSLYFGGQRHIISMKSKNFLESRQLPVFTYNDQGVLFED-----------RPFVQND---CYY 112

  Fly   139 QGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTN---AT 200
            .|.:.|..||:.||:||.|...||:......|.|.|    :.......:||.:.|...|.   ..
Mouse   113 LGFVDGDLESMAALTTCFGGFQGILQINDTAYEIKP----KSPSSTFEHLLYKIDSEKTQLRPMR 173

  Fly   201 CGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDSSQLIRGPYNA-N 264
            ||..               |..:.|.:                   |.|.:..|..::..|.: .
Mouse   174 CGLT---------------DEEIAGQV-------------------RLQENGKSTRMQSIYGSWW 204

  Fly   265 KYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNESNEIEF 329
            .:..|::|.:|:|::.|...::||..|.:....|...||...:.::|.|.|:|:.||...|.|..
Mouse   205 SHGLYIKLALVIDHEQYLYRKKNTSLVIRDVLSIMQGINLFLLSVDINVVLLGLTIWTNGNPIPV 269

  Fly   330 SSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPN 394
             .|....|..|..::.|.|....|.|.|.|.....|: ...|.|..|.:|...:..|:......:
Mouse   270 -QDIYALLPAFCTWKGTNLDSQIPYDIAHLFVNYTFS-NYFGIAYVGTVCDKTFGCGIDSIAEDD 332

  Fly   395 PAMVATTMAHEMGHNFGMEHDTSDCHCRDEKCVMAASSTSFIPVNWSSCSIDQLTIAFSRGMN-Y 458
            ...:...:|||:|||.||.||...|.|.:|.|:|:|:..|  ....|:||.:   :.::..:| .
Mouse   333 FLTIGHIVAHEIGHNLGMSHDGILCTCGEESCLMSATMDS--SQKLSNCSYE---VLWAHMINKS 392

  Fly   459 CLRN--KPERLFESPTCGNGFVEPGEQCDCGLPEHC-ENACCNAQTCMLHSKNATCATGECCDLT 520
            |:..  :|..:|:...||||.||.|||||||..|:| .|.|| ..:|.|.|| |.|.||.||: .
Mouse   393 CIHREPRPSDIFQLKVCGNGIVEEGEQCDCGSSENCRRNRCC-MPSCTLRSK-AKCDTGLCCN-R 454

  Fly   521 TCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTL 585
            .|:.:.:|:.||..||||||||:|.|.|..||.|:|.:|...|. |..||:...|.||...|:.:
Mouse   455 KCQIQPSGTLCRARENECDLPEWCNGTSHECPEDLFVQDGTSCP-GDGYCYEKRCNSHDVHCQRV 518

  Fly   586 WGPTG-DNSEHCYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERLEFGMESAA 648
            :|... ..|:.||.: ||.|.|.||||:  :|..::|||...:.||.:.|..:.        :..
Mouse   519 FGQLAMKASDSCYKELNTRGDRFGNCGF--INNEYVRCEISDILCGRIQCDKVG--------TLP 573

  Fly   649 VLSHSYISH--DRKIVACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPVDAVRQKGMGK 711
            :|.:.|..|  ....|:|.:....||::..|.|...:|..||...:|:.::|     |.:.....
Mouse   574 ILQNHYTIHWTHFNSVSCWSTDYHLGMKIADLGDIKDGTNCGPQHVCIARKC-----VNKPSWVN 633

  Fly   712 PC-PEDCNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSG-PATD---------------PNG 759
            .| ||.||..|:||::.|||||||:...:|.:.|:|||.||| |..:               ||
Mouse   634 DCTPETCNMKGVCNNKQHCHCDVGWSPPNCQETGTGGSIDSGSPGNEVYEDEVVSKKDAPEKPN- 697

  Fly   760 SVGFKRFLYVLFFFVLPV--VALFWFLYHCYKNGMLTRGKLADNILKSSGGSKPITTRTNQNGTG 822
                      :..::||:  ||:...:..|...        |....:.:..|:|...|......|
Mouse   698 ----------VIIWLLPIICVAVVLSVLFCLSG--------ATKKSREAAASQPAEERVKPPYEG 744

  Fly   823 PPPSNGLLK 831
            ..||...:|
Mouse   745 AEPSYETVK 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	53..174	CDD:460254	24/99 (24%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	56/193 (29%)
		Disintegrin	479..554	CDD:459709	40/75 (53%)
		ACR	558..701	CDD:214743	42/146 (29%)
		PHA03247	<823..1261	CDD:223021	3/9 (33%)
		PHA03247	<1220..1392	CDD:223021
Adam24	NP_034216.3	Pep_M12B_propep	42..160	CDD:460254	26/115 (23%)
		Cysteine switch. /evidence=ECO:0000250	172..179		2/21 (10%)
		ZnMc_adamalysin_II_like	209..395	CDD:239797	56/192 (29%)
		Disintegrin	415..488	CDD:459709	40/75 (53%)
		ACR	492..628	CDD:214743	43/151 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	725..761		7/29 (24%)