DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Meltrin and Adam18

DIOPT Version :9

Sequence 1:NP_001027575.1 Gene:Meltrin / 3772109 FlyBaseID:FBgn0265140 Length:1407 Species:Drosophila melanogaster
Sequence 2:NP_034214.2 Gene:Adam18 / 13524 MGIID:105986 Length:719 Species:Mus musculus


Alignment Length:828 Identity:218/828 - (26%)
Similarity:345/828 - (41%) Gaps:184/828 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LFLLPLLLL--------NTCLQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVI---RPQVE 59
            ||:|..|.:        ..||...:.|..|......:||:           .||.:.   :|...
Mouse     4 LFILAELAMLFARLDSEGICLHITVPQKIEPRKGGDAEGK-----------VTYVITIDGKPYSL 57

  Fly    60 HGRTKRSLLTTLDATDGLHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHV 124
            |.| ..|.|:           |..|.||:.        :...|...:||||.:            
Mouse    58 HLR-NHSFLS-----------QNFLVYTYN--------ETGSLYSDSSHFLAH------------ 90

  Fly   125 VTTFTKTEVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLL 189
                       |||:|::...|.|:|.||.|.| |.|.:.....:|.|.| ::...|.:...|.:
Mouse    91 -----------CHYRGYVDEVPNSIVTLSICSG-LRGFLQLENVSYGIEP-LESSARFEHIVYQV 142

  Fly   190 KQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDSS 254
            |.    .::...|.|:|       ..:.|              :||.|.|:       .|..:.|
Mouse   143 KS----DSSMLAGNDSH-------VWQID--------------QLDKGHFN-------EQDKNHS 175

  Fly   255 QLIRGPYNANKYSSYVELVIVVDNKVY----KNFQENTKKVHQYCKGIANIINALYVPLNIFVAL 315
            ||:  |.:       ::|.|:|...::    .:....|:|:.|    |..::||:...|.:.|.|
Mouse   176 QLL--PQS-------LKLHIIVGKFLFDYMGSDIMAITQKIFQ----IIGLVNAMLTQLKLSVVL 227

  Fly   316 VGVVIWNESNEIEFSSDGDLT--LRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPI 378
            ..:.:|::.|.|  |:||:.|  |:..|:::...|.| ..|:...||.... ....:|.|..|.|
Mouse   228 ASLELWSDKNHI--STDGNATDILQRLLDWKRDYLTL-QSNEITHLLIYRR-RPKYIGAASPGEI 288

  Fly   379 CTYEYSGGVSMQHSPNP------AMVATTMAHEMGHNFGMEHDTS--DCHCRDEKCVM---AASS 432
            |:..|..||.|.  |..      ::|.|.:   :|.:.|:.:|.:  :|.|....|:|   |.||
Mouse   289 CSKSYVAGVGMY--PEDIGLEGFSVVITQL---IGLHIGLTYDDNIRNCSCPSAPCIMQQGALSS 348

  Fly   433 TSFIPVNWSSCSIDQLTIAFSRGMNYCLRN-------KPERLFESPTCGNGFVEPGEQCDCGLPE 490
            :.  ...:|:||:.......|.....||.:       :|.:    ..||||.:|.||:||||...
Mouse   349 SG--KKTFSNCSLHDYMHYVSNFDTQCLGDLSNVHVLQPNQ----AVCGNGIMEAGEECDCGNET 407

  Fly   491 HCE-NACCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREA-ENECDLPEYCTGESEYCPA 553
            .|: ..||:.:||.|.. :|.|.:|.|| :.||....:|:.||:| :.|||..|||.|.|.:|..
Mouse   408 ECQFKECCDHETCRLKG-SAQCGSGACC-MPTCELSASGTPCRKAVDPECDFTEYCDGSSSHCVP 470

  Fly   554 DVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWGPTGDNSEH-CYNK-NTEGTRLGNCGYNRLNK 616
            |.|..:...|..|.|||::|.|::.::||.:|:|.....:.: |:.| |:....|.||  :..:.
Mouse   471 DTFALNGHLCRLGSAYCYNGRCQALNDQCVSLFGKGSQGASYACFEKVNSPRENLANC--DSKDS 533

  Fly   617 TFLRCEEQHVNCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQT--TDPG 679
            ..:.|.:|.|.||.|.|....:..:...:|..   :||: ||.   .|.:.|..|.:::  .|..
Mouse   534 YSVPCGQQDVLCGKLACFRPPKNYKSPSQSVV---YSYV-HDS---VCLSILPGLSMRSDGRDSA 591

  Fly   680 LTPNGAKCGVDKMCVDQRCLPVDAVRQKGMGKPC--PEDCNGNGICNSRGHCHCDVGFGGESCS- 741
            ...:|..||....|::..|..|:..     |..|  .:.|.||||||:.|:|.|...:....|: 
Mouse   592 YVADGTVCGPQMYCINGTCKEVNFT-----GNDCNATKKCKGNGICNNFGNCQCFPDYRPPDCNL 651

  Fly   742 KAGS-GGSPDSGPATDPNGSVGFKR-------FLYVLFFFVLPVVALF 781
            :.|| |||.|.|.......:...||       ::.:.||..||.:..|
Mouse   652 QIGSPGGSIDDGNTLRTESAFATKRLSKNEDSWVILGFFIFLPFIVTF 699

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MeltrinNP_001027575.1 Pep_M12B_propep 64..174 CDD:279848 26/109 (24%)
Reprolysin 269..464 CDD:279729 54/218 (25%)
ZnMc_adamalysin_II_like 269..462 CDD:239797 54/209 (26%)
Disintegrin 479..555 CDD:278623 33/77 (43%)
ACR 558..701 CDD:214743 38/146 (26%)
Adam18NP_034214.2 Pep_M12B_propep 30..139 CDD:279848 37/164 (23%)
Reprolysin 182..374 CDD:279729 52/206 (25%)
ZnMc_adamalysin_II_like 182..374 CDD:239797 52/206 (25%)
Disintegrin 396..472 CDD:278623 33/77 (43%)
ACR 475..613 CDD:214743 38/146 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3607
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D162519at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11905
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.920

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