DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and Adam28

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_034212.1	Gene:	Adam28 / 13522	MGIID:	105988	Length:	793	Species:	Mus musculus

Alignment Length:	944	Identity:	266/944 - (28%)
Similarity:	394/944 - (41%)	Gaps:	198/944 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRTKRSLLTTLDATDGLHTPQISLSY 86
            :|.|...:|.  .|..|:|.:.|:.....:.:.:.:.:....|.:..|           ::....
Mouse    12 LLSPVPVSAI--KELPKAKKYEVVYPIRLHPLRKRETQEPEPKETFET-----------ELRYKM 63

  Fly    87 THEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTKTEVDLCHYQGHIRGKPESVVA 151
            |..||..|:.|::|:.||...:...|.|:|     |:.|||..:. :|.|:|||||..:..|..:
Mouse    64 TVNGKVAVLYLKKNNKLLAPDYSETYYNSS-----GNKVTTSPQI-MDSCYYQGHIVNEKVSAAS 122

  Fly   152 LSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTNATCGYDNHRDDHSHDYEK 216
            :|||.| |.|.:..|.:.|||.| :......:..|.|.|                 ||.:.|.||
Mouse   123 ISTCQG-LRGYISQGDEKYFIEP-LSSENLDEQAHALFK-----------------DDSNEDQEK 168

  Fly   217 ADGD-------NGLGGGIPSLP----LRLDGGEFSRTLLRKRRQADDSSQLIRGPYNANKYSSYV 270
            ::..       .||...: :||    ::|:.|                  :::.|      ..|:
Mouse   169 SNCGVDDALWLQGLHQDV-ALPATRLIKLNDG------------------MVQEP------KKYI 208

  Fly   271 ELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNESNEIEFSSDGDL 335
            |..:|:||..:|.:.:|..::.:....:||.||.||..|:..||||||.||.:.::|:.:.|.:.
Mouse   209 EYYVVLDNGEFKKYNKNLAEIRKIVLEMANYINMLYNKLDAHVALVGVEIWTDGDKIKITPDANT 273

  Fly   336 TLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPNPAMVAT 400
            ||.||..:|...|:....:|.|||::..:|:|..||.|....:|:..:|.|:...||.....||.
Mouse   274 TLENFSKWRGNDLLKRKHHDIAQLISSTDFSGSTVGLAFMSSMCSPYHSVGIVQDHSNYHLRVAG 338

  Fly   401 TMAHEMGHNFGMEHDTSDCHCRDEKCVMAASSTSFIPVNWSSCSIDQLTIAFSRGMNYCLRNK-- 463
            |||||||||.||.||...|.|..|.|||..|....:|.::||||...........:::||.|.
Mouse   339 TMAHEMGHNLGMIHDYLSCKCPSEVCVMEQSLRFHMPTDFSSCSRVNYKQFLEEKLSHCLFNSPL 403

  Fly   464 PERLFESPTCGNGFVEPGEQCDCGLPEHCENACCNAQTCMLHSKNATCATGECCDLTTCRPKLAG 528
            |..:..:|.|||..:|..|.||||.|:.|.|.||:|:||.:.: ...||.||||:  .|:.|..|
Mouse   404 PSDIISTPVCGNQLLEMNEDCDCGTPKECTNKCCDARTCKIKA-GFQCALGECCE--KCQLKKPG 465

  Fly   529 SACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWGP-TGDN 592
            ..||.|::||||||.|.|:|.:||.|.||.:..||..|..||..|.|.:...||..:||| |...
Mouse   466 VVCRAAKDECDLPEVCDGKSSHCPGDRFRVNGSPCQNGHGYCLKGKCPTLQQQCMDMWGPGTKVA 530

  Fly   593 SEHCYNKNTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERLEFGMESA--AVLSHSYI 655
            :..||.:|..||:.|.|...  |.|.:.|:.:...||.|.|       |.|....  ..|:.|::
Mouse   531 NTSCYKQNEGGTKYGYCHVE--NGTHMPCKAKDAMCGKLFC-------EGGSGDLPWKGLTISFL 586

  Fly   656 SHDRKIVACRTALVDLGLQTTDPG--LTPNGAKCGVDKMCVDQRCLPVDAVRQKGMGKPCPEDCN 718
            :       |:  |.|  .:.|..|  :..||.|||.:|:|::..|:.::...:..   .|...|.
Mouse   587 T-------CK--LFD--PEDTSQGVDMVANGTKCGTNKVCINAECVDMEKTYKSA---NCSSKCK 637

  Fly   719 GNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSGPATDPNGSVGFKRFLYVLFFFVLPVVALFWF 783
            |:.:|:....|.|..|:....|.                |.:..|...:.|...|.|.|:.:.
Mouse   638 GHAVCDHELQCQCKEGWAPPDCE----------------NSATVFHFSIVVGVLFPLAVIFVV-- 684

  Fly   784 LYHCYKNGMLTRGKLADNILKSSGGSKPITTRTNQNGTGPPPSNGLLKSTPSSTDDMDSALLKSP 848
                          :|..|.:.|...|                ...::..||:.|
Mouse   685 --------------VAIVIQRQSARRK----------------QRRVQRLPSTKD---------- 709

  Fly   849 SDSTPSAGLFGKFDGFTLRPLNDASSPASNYNGPNVAFVQPTVQ--------QDGPQRMAPPPPV 905
                      .|......||             ..|..|||...        .|.|.....|||.
Mouse   710 ----------AKLHNQKCRP-------------QKVKDVQPQEMSQMKKLHVSDLPSEEPEPPPD 751

  Fly   906 VKPGTAPIHPPSPKP-EATWVRPAPALPPPNPGS 938
            |.. |.|..||.|.| ..|.....|.:..|:|.|
Mouse   752 VLI-TKPNFPPPPIPVSLTGRAKVPFVKTPHPFS 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	35/109 (32%)
		Reprolysin	269..464	CDD:279729	74/196 (38%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	73/192 (38%)
		Disintegrin	479..555	CDD:278623	37/75 (49%)
		ACR	558..701	CDD:214743	44/147 (30%)
Adam28	NP_034212.1	Pep_M12B_propep	42..156	CDD:279848	36/132 (27%)
		Cysteine switch. /evidence=ECO:0000250	169..176		0/6 (0%)
		Reprolysin	206..402	CDD:279729	74/195 (38%)
		ZnMc_adamalysin_II_like	206..400	CDD:239797	73/193 (38%)
		Disintegrin	419..491	CDD:278623	37/74 (50%)
		ACR	496..623	CDD:214743	44/146 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	699..759		18/93 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4215
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0000154
OrthoInspector	1	1.000	-	-		otm43605
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.950