DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meltrin and Adam9

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001257925.1	Gene:	Adam9 / 11502	MGIID:	105376	Length:	863	Species:	Mus musculus

Alignment Length:	951	Identity:	286/951 - (30%)
Similarity:	425/951 - (44%)	Gaps:	179/951 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PVLE----------EFSTYTVIRPQVEHGRTKRSLLTTLDATDGLHTPQISLSYTHEGKRVVVDL 97
            ||||          ..|:|.:|.|. ...|.:|..|       |..:.|||.....:||:.::.|
Mouse    25 PVLEAGRPDLEQTVHLSSYEIITPW-RLTRERREAL-------GPSSQQISYVIQAQGKQHIIHL 81

  Fly    98 QRNDLLLPNSHFLRYQNASRGA-------TPGHVVTTFTKTEVDLCHYQGHIRGKPESVVALSTC 155
            :||..||||. |:.|.....|:       ...|            |||:|::.|...|.||:|.|
Mouse    82 ERNTDLLPND-FVVYTYDKEGSLLSDHPNVQSH------------CHYRGYVEGVQNSAVAVSAC 133

  Fly   156 DGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTNATCGYDN-HRDDH-SHDYEKAD 218
            .| |.|:                               :|..||:.|.:. |...| .|.:...|
Mouse   134 FG-LRGL-------------------------------LHLENASFGIEPLHNSSHFEHIFYPMD 166

  Fly   219 GDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDS-----SQLIRGPYNANKYSSYVELVIVVDN 278
                   ||...|||.  |..:|...::..|.|:.     :||:|........:.||||.||||.
Mouse   167 -------GIHQEPLRC--GVSNRDTEKEGTQGDEEEHPSVTQLLRRRRAVLPQTRYVELFIVVDK 222

  Fly   279 KVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNESNEIEFSSDGDLTLRNFLNY 343
            :.|.....|...|.:....:||.::::|:.|||.:.|||:.||.:.|.|.........|.||:.:
Mouse   223 ERYDMMGRNQTAVREEMIRLANYLDSMYIMLNIRIVLVGLEIWTDRNPINIIGGAGDVLGNFVQW 287

  Fly   344 RSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPNPAMVATTMAHEMGH 408
            |...|:....:|:|||:.|:.| ||..|.|..|.:|:..::||:::.........|:.:|||:||
Mouse   288 REKFLITRWRHDSAQLVLKKGF-GGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGH 351

  Fly   409 NFGMEHDTS-DCHCRDEKCVMAASSTSFIPVNWSSCS---IDQLTIAFSRGMNYCLRN--KPERL 467
            |.||.||.. :|.|..:.|:|.:.::.  ..|:||||   .::||:  ::| ..||.|  ||:..
Mouse   352 NLGMNHDDGRECFCGAKSCIMNSGASG--SRNFSSCSAEDFEKLTL--NKG-GSCLLNIPKPDEA 411

  Fly   468 FESPTCGNGFVEPGEQCDCGLPEHCE-NACCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSAC 531
            :.:|:|||..|:|||:||||..:.|| :.||...||.|.| .|.||.|:||  ..|:....||.|
Mouse   412 YSAPSCGNKLVDPGEECDCGTAKECEVDPCCEGSTCKLKS-FAECAYGDCC--KDCQFLPGGSMC 473

  Fly   532 REAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWGPTGDNS-EH 595
            |...:|||:||||.|.|::||.|||.::..||...:|||::|.|:.:..||:.::|.....: ..
Mouse   474 RGKTSECDVPEYCNGSSQFCPPDVFIQNGYPCQNSKAYCYNGMCQYYDAQCQVIFGSKAKAAPRD 538

  Fly   596 CY-NKNTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERLEFGMESAAVLSHSYISHDR 659
            |: ..|::|.|.||||::  ...:.:|...:..||.|.|.::.:...||:..|.:.:.|
Mouse   539 CFIEVNSKGDRFGNCGFS--GSEYKKCATGNALCGKLQCENVQDMPVFGIVPAIIQTPS------ 595

  Fly   660 KIVACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPVDAVRQKG--MGKPCPEDCNGNGI 722
            :...|......||....|||:...|.||...|:|.:.:|:....:....  .||     |:|:|:
Mouse   596 RGTKCWGVDFQLGSDVPDPGMVNEGTKCDAGKICRNFQCVNASVLNYDCDIQGK-----CHGHGV 655

  Fly   723 CNSRGHCHCDVGFGGESCSKAGSGGSPDSGPATDPNGSVGFKRFLYVLFFFVLPVVALFWFLY-- 785
            |||..:|||:.|:....|...|.|||.||||..:.. |...:..|.|.||.::|:||...||:
Mouse   656 CNSNKNCHCEDGWAPPHCDTKGYGGSVDSGPTYNAK-STALRDGLLVFFFLIVPLVAAAIFLFIK 719

  Fly   786 -------HCYKNGMLTRGKLADNILKSSGGSKPITTRTNQNGTGPPPSNGLLKSTPSSTDDMDSA 843
                   ...|...::.|:...|:.:..|...........|.:.||...|:  |.|..
Mouse   720 RDELRKTFRKKRSQMSDGRNQANVSRQPGDPSISRPPGGPNVSRPPGGPGV--SRPPG------- 775

  Fly   844 LLKSPSDSTPSAGLFGKFDGFTLRPLNDASSPASNYNGPNVAFVQPTVQQDGPQRMAPPP----- 903
               .|..|.|..|     .|.:..|           .||.|:  :|   ..||....|||
Mouse   776 ---GPGVSRPPGG-----PGVSRPP-----------GGPGVS--RP---PGGPGVSRPPPGHGNR 816

  Fly   904 -PV-----VKPGTAPIHPPSPKPEATW------VRPAPALP 932
             ||     .:|...|..||.|:|:.:.      .|||||.|
Mouse   817 FPVPTYAAKQPAQFPSRPPPPQPKISSQGNLIPARPAPAPP 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	32/116 (28%)
		Reprolysin	269..464	CDD:279729	69/200 (35%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	68/196 (35%)
		Disintegrin	479..555	CDD:278623	37/76 (49%)
		ACR	558..701	CDD:214743	39/144 (27%)
Adam9	NP_001257925.1	Pep_M12B_propep	55..160	CDD:279848	38/156 (24%)
		Reprolysin	212..406	CDD:279729	69/199 (35%)
		ZnMc_adamalysin_II_like	212..404	CDD:239797	68/197 (35%)
		Disintegrin	423..497	CDD:278623	37/76 (49%)
		ACR	500..636	CDD:214743	39/143 (27%)
		Drf_FH1	<747..820	CDD:283903	23/105 (22%)
		Collagen	755..810	CDD:189968	18/87 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1692
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43605
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.100