Protein Alignment Meltrin and Adam9

DIOPT Version :10

• Sequence 1: NP_001027575.1
• Gene: Meltrin / 3772109
• FlyBaseID: FBgn0265140
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: NP_001257925.1
• Gene: Adam9 / 11502
• MGIID: 105376
• Length: 863
• Species: Mus musculus
• Alignment Length: 954
• Identity: 288/954 - (30%)
• Similarity: 426/954 - (44%)
• Gaps: 185/954 - (19%)

  Fly    43 PVLE----------EFSTYTVIRPQVEHGRTKRSLLTTLDATDGLHTPQISLSYTHEGKRVVVDL 97
            ||||          ..|:|.:|.|. ...|.:|..|       |..:.|||.....:||:.::.|
Mouse    25 PVLEAGRPDLEQTVHLSSYEIITPW-RLTRERREAL-------GPSSQQISYVIQAQGKQHIIHL 81

  Fly    98 QRNDLLLPNSHFLRYQNASRGATPGHVVTTFTKTEVDL----------CHYQGHIRGKPESVVAL 152
            :||..||||.               .||.|:.| |..|          |||:|::.|...|.||:
Mouse    82 ERNTDLLPND---------------FVVYTYDK-EGSLLSDHPNVQSHCHYRGYVEGVQNSAVAV 130

  Fly   153 STCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTNATCGYDN-HRDDH-SHDYE 215
            |.|.| |.|:                               :|..||:.|.:. |...| .|.:.
Mouse   131 SACFG-LRGL-------------------------------LHLENASFGIEPLHNSSHFEHIFY 163

  Fly   216 KADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDS-----SQLIRGPYNANKYSSYVELVIV 275
            ..|       ||...|||.  |..:|...::..|.|:.     :||:|........:.||||.||
Mouse   164 PMD-------GIHQEPLRC--GVSNRDTEKEGTQGDEEEHPSVTQLLRRRRAVLPQTRYVELFIV 219

  Fly   276 VDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNESNEIEFSSDGDLTLRNF 340
            ||.:.|.....|...|.:....:||.::::|:.|||.:.|||:.||.:.|.|.........|.||
Mouse   220 VDKERYDMMGRNQTAVREEMIRLANYLDSMYIMLNIRIVLVGLEIWTDRNPINIIGGAGDVLGNF 284

  Fly   341 LNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPNPAMVATTMAHE 405
            :.:|...|:....:|:|||:.|:.| ||..|.|..|.:|:..::||:::.........|:.:|||
Mouse   285 VQWREKFLITRWRHDSAQLVLKKGF-GGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHE 348

  Fly   406 MGHNFGMEHDTS-DCHCRDEKCVMAASSTSFIPVNWSSCS---IDQLTIAFSRGMNYCLRN--KP 464
            :|||.||.||.. :|.|..:.|:|.:.::.  ..|:||||   .::||:  ::| ..||.|  ||
Mouse   349 LGHNLGMNHDDGRECFCGAKSCIMNSGASG--SRNFSSCSAEDFEKLTL--NKG-GSCLLNIPKP 408

  Fly   465 ERLFESPTCGNGFVEPGEQCDCGLPEHCE-NACCNAQTCMLHSKNATCATGECCDLTTCRPKLAG 528
            :..:.:|:|||..|:|||:||||..:.|| :.||...||.|.| .|.||.|:||  ..|:....|
Mouse   409 DEAYSAPSCGNKLVDPGEECDCGTAKECEVDPCCEGSTCKLKS-FAECAYGDCC--KDCQFLPGG 470

  Fly   529 SACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWGPTGDNS 593
            |.||...:|||:||||.|.|::||.|||.::..||...:|||::|.|:.:..||:.::|.....:
Mouse   471 SMCRGKTSECDVPEYCNGSSQFCPPDVFIQNGYPCQNSKAYCYNGMCQYYDAQCQVIFGSKAKAA 535

  Fly   594 -EHCY-NKNTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERLEFGMESAAVLSHSYIS 656
             ..|: ..|::|.|.||||::  ...:.:|...:..||.|.|.::.:...||:..|.:.:.|
Mouse   536 PRDCFIEVNSKGDRFGNCGFS--GSEYKKCATGNALCGKLQCENVQDMPVFGIVPAIIQTPS--- 595

  Fly   657 HDRKIVACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPVDAVRQKG--MGKPCPEDCNG 719
               :...|......||....|||:...|.||...|:|.:.:|:....:....  .||     |:|
Mouse   596 ---RGTKCWGVDFQLGSDVPDPGMVNEGTKCDAGKICRNFQCVNASVLNYDCDIQGK-----CHG 652

  Fly   720 NGICNSRGHCHCDVGFGGESCSKAGSGGSPDSGPATDPNGSVGFKRFLYVLFFFVLPVVALFWFL 784
            :|:|||..:|||:.|:....|...|.|||.||||..:.. |...:..|.|.||.::|:||...||
Mouse   653 HGVCNSNKNCHCEDGWAPPHCDTKGYGGSVDSGPTYNAK-STALRDGLLVFFFLIVPLVAAAIFL 716

  Fly   785 Y---------HCYKNGMLTRGKLADNILKSSGGSKPITTRTNQNGTGPPPSNGLLKSTPSSTDDM 840
            :         ...|...::.|:...|:.:..|...........|.:.||...|:  |.|..
Mouse   717 FIKRDELRKTFRKKRSQMSDGRNQANVSRQPGDPSISRPPGGPNVSRPPGGPGV--SRPPG---- 775

  Fly   841 DSALLKSPSDSTPSAGLFGKFDGFTLRPLNDASSPASNYNGPNVAFVQPTVQQDGPQRMAPPP-- 903
                  .|..|.|..|     .|.:..|           .||.|:  :|   ..||....|||
Mouse   776 ------GPGVSRPPGG-----PGVSRPP-----------GGPGVS--RP---PGGPGVSRPPPGH 813

  Fly   904 ----PV-----VKPGTAPIHPPSPKPEATW------VRPAPALP 932
                ||     .:|...|..||.|:|:.:.      .|||||.|
Mouse   814 GNRFPVPTYAAKQPAQFPSRPPPPQPKISSQGNLIPARPAPAPP 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	53..174	CDD:460254	37/130 (28%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	68/196 (35%)
		Disintegrin	479..554	CDD:459709	37/75 (49%)
		ACR	558..701	CDD:214743	39/144 (27%)
		PHA03247	<823..1261	CDD:223021	34/127 (27%)
		PHA03247	<1220..1392	CDD:223021
Adam9	NP_001257925.1	Pep_M12B_propep	44..163	CDD:460254	44/174 (25%)
		Reprolysin	212..406	CDD:426256	69/199 (35%)
		Disintegrin	423..496	CDD:459709	37/75 (49%)
		ACR	500..636	CDD:214743	39/143 (27%)
		EGF_2	650..673	CDD:400365	10/22 (45%)
		Drf_FH1	<747..820	CDD:461881	23/105 (22%)