DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meltrin and Adam5

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001258987.1	Gene:	Adam5 / 11499	MGIID:	104730	Length:	771	Species:	Mus musculus

Alignment Length:	822	Identity:	203/822 - (24%)
Similarity:	340/822 - (41%)	Gaps:	156/822 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 TTLDAT--DGLHTPQISL-SYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTK 130
            |||..|  :.:.:|.:.. :..|....:.::        ...||:..:..| ..||..||.|:.:
Mouse    23 TTLQTTVPEKISSPDVETDAEDHMAYLITIN--------ETPHFIHLKKQS-FITPTAVVYTYDR 78

  Fly   131 TEV---------DLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDH 186
            .:|         :.|:|.|::.|.|.|:|.|:.|.| |.||:.....:|.|.|.....|.:   |
Mouse    79 NDVQHSQPLSALENCNYNGYVAGFPNSIVTLTVCTG-LRGIIQFENVSYAIEPVETLSGFV---H 139

  Fly   187 YLLKQADMHPTNATCGYDNHRD--DHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQ 249
            .:.:..:.|......|.:....  |.| ||:                .|.:..:...|:||:|
Mouse   140 VIYENTNKHAVIPDLGKNQSYSWFDES-DYQ----------------FRSNMKKSGFTVLRQR-- 185

  Fly   250 ADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVA 314
                               ::.:.|:||.|::.....:|:.|.|....|...:|.:...|.:.|.
Mouse   186 -------------------FIMMDIIVDKKLFDYMGSDTEVVLQKVIQIIGFVNTMLSKLKLTVL 231

  Fly   315 LVGVVIWNESNEIEFSSDGDLTLRNFL----NYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALK 375
            :..:.||::.|.|..|...|..|..|.    .|||..:        |.||..|..... .|....
Mouse   232 INSIEIWSKENRIRLSKAVDDLLVQFSIWKHEYRSQHV--------AYLLAFEEHPAS-TGALYP 287

  Fly   376 GPICTYEYSGGVSMQHSPNPAMV---ATTMAHEMGHNFGMEHDTSDCHCRDEKCVMAASSTSFIP 437
            |.:|..||:..|::.  |....:   :..:...:....|:.:||.:|||..|.|:|...:.....
Mouse   288 GNLCKLEYNAAVALY--PKGLSLESFSVIVLQLLSIGMGLTYDTENCHCTGEVCLMTPKAIYSGG 350

  Fly   438 V-NWSSCSIDQLTIAFSRGMNYCLRN---------KPERLFESPTCGNGFVEPGEQCDCGLPEHC 492
            | ::|:|::|......:|....||::         :|.|:     ||||.:|..||||||..::|
Mouse   351 VKDFSTCTLDDFKYLSTRQDLRCLQDLPLERKPARRPRRI-----CGNGILEMNEQCDCGTLKNC 410

  Fly   493 -ENACCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVF 556
             ...||:..:|.|.:| |||.:||||. ..|..|:....||::.:|||..|||.|:..||..:.:
Mouse   411 THRKCCDPMSCRLKNK-ATCGSGECCS-QDCTVKMNDVVCRKSVDECDFVEYCNGKDPYCVPNTY 473

  Fly   557 RRDTEPCDGGQAYCFHGTCRSHSNQCRTLWGP-TGDNSEHCYNK-NTEGTRLGNCGYNRLNKTFL 619
            .|:.:.|:.|:|:||.|.|::...||.::.|. ....|..||.: |:.|.|.|||.:|
Mouse   474 ARNGQYCESGEAFCFEGRCQTADKQCMSMLGKYVRGASFACYEEFNSRGDRFGNCIHN------- 531

  Fly   620 RCEEQHVNCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTT-------D 677
            .|..::..||.|.|....::|.  :::...::::.|..|..:...:...:....:||       |
Mouse   532 FCAFRNSLCGKLICTWPFKKLV--LKANLSVAYAQIRDDLCVAMYKGGRIPKTTKTTYSNPADRD 594

  Fly   678 PGLTPNGAKCGVDKMCVDQRCLPV---------DAVRQKGMGKPCPEDCNGNGICNSRGHCHCDV 733
            .....:|..||.|..|:...|...         |:.|          |||.:|:||:..|||||:
Mouse   595 ETFVNDGTICGPDMFCLRASCTETRFHMDSSKCDSTR----------DCNDHGVCNNLQHCHCDI 649

  Fly   734 GFGGESCSK-AGSGGSPDSGPATDPNGSVGFKR---------FLYVLFFFVLPVVALFWFLYHCY 788
            |:....|.: .|..||.|.|..........:|:         .|.::.:..||::.:...:  ..
Mouse   650 GYNPPFCEEHKGQFGSVDDGHKYHVEDGKSYKQQSHSNLKKNQLQLILYISLPLLVMISAV--VI 712

  Fly   789 KNGMLT------RGKLADNILKSSGGSKPITTRTNQNGTGPP 824
            |...|:      |.:...:..:.||.:..:|:....:.|.||
Mouse   713 KQSKLSRVCDRERSESDSSTTEDSGSNTNVTSSGGSSSTDPP 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	30/116 (26%)
		Reprolysin	269..464	CDD:279729	49/211 (23%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	49/200 (25%)
		Disintegrin	479..555	CDD:278623	33/76 (43%)
		ACR	558..701	CDD:214743	38/151 (25%)
Adam5	NP_001258987.1	Pep_M12B_propep	35..141	CDD:279848	29/118 (25%)
		Reprolysin	185..378	CDD:279729	50/224 (22%)
		ZnMc_adamalysin_II_like	185..376	CDD:239797	50/222 (23%)
		DISIN	397..473	CDD:214490	33/77 (43%)
		ACR	475..618	CDD:214743	38/151 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920