Protein Alignment Meltrin and Adam5

DIOPT Version :10

• Sequence 1: NP_001027575.1
• Gene: Meltrin / 3772109
• FlyBaseID: FBgn0265140
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: NP_001258987.1
• Gene: Adam5 / 11499
• MGIID: 104730
• Length: 771
• Species: Mus musculus
• Alignment Length: 819
• Identity: 204/819 - (24%)
• Similarity: 339/819 - (41%)
• Gaps: 150/819 - (18%)

  Fly    69 TTLDAT--DGLHTPQISL-SYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTK 130
            |||..|  :.:.:|.:.. :..|....:.::        ...||:..:..| ..||..||.|:.:
Mouse    23 TTLQTTVPEKISSPDVETDAEDHMAYLITIN--------ETPHFIHLKKQS-FITPTAVVYTYDR 78

  Fly   131 TEV---------DLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDH 186
            .:|         :.|:|.|::.|.|.|:|.|:.|.| |.||:.....:|.|.|.....|.:   |
Mouse    79 NDVQHSQPLSALENCNYNGYVAGFPNSIVTLTVCTG-LRGIIQFENVSYAIEPVETLSGFV---H 139

  Fly   187 YLLKQADMHPTNATCGYDNHRD--DHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQ 249
            .:.:..:.|......|.:....  |.| ||:                .|.:..:...|:||:|
Mouse   140 VIYENTNKHAVIPDLGKNQSYSWFDES-DYQ----------------FRSNMKKSGFTVLRQR-- 185

  Fly   250 ADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVA 314
                               ::.:.|:||.|::.....:|:.|.|....|...:|.:...|.:.|.
Mouse   186 -------------------FIMMDIIVDKKLFDYMGSDTEVVLQKVIQIIGFVNTMLSKLKLTVL 231

  Fly   315 LVGVVIWNESNEIEFSSDGDLTLRNFL----NYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALK 375
            :..:.||::.|.|..|...|..|..|.    .|||..:        |.||..|..... .|....
Mouse   232 INSIEIWSKENRIRLSKAVDDLLVQFSIWKHEYRSQHV--------AYLLAFEEHPAS-TGALYP 287

  Fly   376 GPICTYEYSGGVSMQHSPNPAMV---ATTMAHEMGHNFGMEHDTSDCHCRDEKCVMAASSTSFIP 437
            |.:|..||:..|::.  |....:   :..:...:....|:.:||.:|||..|.|:|...:.....
Mouse   288 GNLCKLEYNAAVALY--PKGLSLESFSVIVLQLLSIGMGLTYDTENCHCTGEVCLMTPKAIYSGG 350

  Fly   438 V-NWSSCSIDQLTIAFSRGMNYCLRNKPERLFESPT------CGNGFVEPGEQCDCGLPEHC-EN 494
            | ::|:|::|......:|....||::.|  |...|.      ||||.:|..||||||..::| ..
Mouse   351 VKDFSTCTLDDFKYLSTRQDLRCLQDLP--LERKPARRPRRICGNGILEMNEQCDCGTLKNCTHR 413

  Fly   495 ACCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRD 559
            .||:..:|.|.:| |||.:||||. ..|..|:....||::.:|||..|||.|:..||..:.:.|:
Mouse   414 KCCDPMSCRLKNK-ATCGSGECCS-QDCTVKMNDVVCRKSVDECDFVEYCNGKDPYCVPNTYARN 476

  Fly   560 TEPCDGGQAYCFHGTCRSHSNQCRTLWGP-TGDNSEHCYNK-NTEGTRLGNCGYNRLNKTFLRCE 622
            .:.|:.|:|:||.|.|::...||.::.|. ....|..||.: |:.|.|.|||.:|       .|.
Mouse   477 GQYCESGEAFCFEGRCQTADKQCMSMLGKYVRGASFACYEEFNSRGDRFGNCIHN-------FCA 534

  Fly   623 EQHVNCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTT-------DPGL 680
            .::..||.|.|....::|.  :::...::::.|..|..:...:...:....:||       |...
Mouse   535 FRNSLCGKLICTWPFKKLV--LKANLSVAYAQIRDDLCVAMYKGGRIPKTTKTTYSNPADRDETF 597

  Fly   681 TPNGAKCGVDKMCVDQRCLPV---------DAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGFG 736
            ..:|..||.|..|:...|...         |:.|          |||.:|:||:..|||||:|:.
Mouse   598 VNDGTICGPDMFCLRASCTETRFHMDSSKCDSTR----------DCNDHGVCNNLQHCHCDIGYN 652

  Fly   737 GESCSK-AGSGGSPDSGPATDPNGSVGFKR---------FLYVLFFFVLPVVALFWFLYHCYKNG 791
            ...|.: .|..||.|.|..........:|:         .|.::.:..||::.:...:  ..|..
Mouse   653 PPFCEEHKGQFGSVDDGHKYHVEDGKSYKQQSHSNLKKNQLQLILYISLPLLVMISAV--VIKQS 715

  Fly   792 MLT------RGKLADNILKSSGGSKPITTRTNQNGTGPP 824
            .|:      |.:...:..:.||.:..:|:....:.|.||
Mouse   716 KLSRVCDRERSESDSSTTEDSGSNTNVTSSGGSSSTDPP 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	53..174	CDD:460254	30/116 (26%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	49/200 (25%)
		Disintegrin	479..554	CDD:459709	33/75 (44%)
		ACR	558..701	CDD:214743	38/151 (25%)
		PHA03247	<823..1261	CDD:223021	2/2 (100%)
		PHA03247	<1220..1392	CDD:223021
Adam5	NP_001258987.1	Pep_M12B_propep	26..142	CDD:460254	30/128 (23%)
		Reprolysin	185..378	CDD:426256	50/224 (22%)
		DISIN	397..473	CDD:214490	33/77 (43%)
		ACR	475..618	CDD:214743	38/151 (25%)