DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meltrin and Adam4

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_033750.1	Gene:	Adam4 / 11498	MGIID:	104731	Length:	763	Species:	Mus musculus

Alignment Length:	764	Identity:	204/764 - (26%)
Similarity:	304/764 - (39%)	Gaps:	167/764 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 FSTYTVIRPQVEHGRTKRSLLTTLDATDGLHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLRY 112
            |||..::.|:....|..:|.:          :..|:.|....|:|.||.::....::| .:|..|
Mouse    42 FSTSEIVIPRKVPQRMGKSDM----------SGHITYSMRFRGQRHVVHMKLKKNMIP-QNFPVY 95

  Fly   113 QNASRGATPGHVVTTFTKTEVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHP--- 174
            .:..:||.....  .|...:   |::...:.|.|.|...|.||.|.|.|::.....||.|.|
Mouse    96 TSNDQGAQQKDY--PFVPRD---CYFYSFLEGVPGSQAILDTCTGGLKGMIQVDDFTYEIKPLAS 155

  Fly   175 -----H------IDGRGR----LQDDHYLLKQADMHPTNATCG---------YDNHRDD---H-- 210
                 |      :|.|.|    .::|..:.|..|:.......|         :..|...   |
Mouse   156 SSKFEHVISLLVVDERSRESKKCRNDEIMAKAGDLSEETKLAGSPRAAPVYLWRYHLKSVGIHYT 220

  Fly   211 -SHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDSSQLIRGPYNANKYSSYVELVI 274
             :||..|..|.|.                                            |:.|||::
Mouse   221 VTHDLFKQTGSNS--------------------------------------------STSVELIL 241

  Fly   275 V---VDNKVYKNFQENTKKVHQYCKG--IANIINALYVP-----LNIFVALVGVVIWNESNEIEF 329
            :   :.:.:||     ...:..|.:|  |.|..|...||     |:.:..:.|..:| :|.|:.
Mouse   242 IMNSISDSIYK-----ISGLIVYARGVWIWNTKNLHTVPGENPHLDPWSVMAGFGVW-KSKELH- 299

  Fly   330 SSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPN 394
                ||       |.:|.::|.....|...   .:|..|:..... |.:.||     |...|.
Mouse   300 ----DL-------YATTAILLASRPKNTDY---GSFQNGLCNPNW-GVLFTY-----VGKNHL-- 342

  Fly   395 PAMVATTMAHEMGHNFGMEHDTSDCHC-RDEKCVMAASSTSFIPVNWSSCSIDQLTIAFSRGMNY 458
             .:..:.:||.:||...:.|||..|.| |...|:|....|....:  |:||.::|.... ...:.
Mouse   343 -FLAGSFLAHAVGHLLDVSHDTPGCVCFRRSSCLMDEFPTLHDMI--SNCSHNELHRRI-HDWDP 403

  Fly   459 CL-----RNKPERLFESPTCGNGFVEPGEQCDCGLPEHCENACCNAQTCMLHSKNATCATGECCD 518
            ||     ..|...::|.|.|||..||..|:||||..:.|....|....|.. ::.::||.|.||
Mouse   404 CLSLELKTAKEVNMYEVPRCGNKRVEASEKCDCGSVKDCTTDKCCEVNCEF-TQGSSCAAGGCC- 466

  Fly   519 LTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQCR 583
             .:|:....|:.||:....|||||||:|.||:||.:.:..|..|| ...|.|..|.|.....||:
Mouse   467 -LSCKFAPTGTICRDKNGICDLPEYCSGASEHCPGNFYIMDGTPC-SPLAVCIAGNCSDRHLQCQ 529

  Fly   584 TLWG-PTGDNSEHCYNK-NTEGTRLGNCGYN--RLNKTFLRCEEQHVNCGMLHCIHLNERLEFGM 644
            .|:| ...|.|..|||: |.:|.|.||||..  |.....:.|:::.|.|||:||..:: .:..|.
Mouse   530 ALFGYQVKDGSPACYNELNVKGDRFGNCGIRIIRGGSQPVPCQKEDVFCGMIHCDGVS-HIPGGG 593

  Fly   645 ESAAVLSHSYISH----DRKIVACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPVDAVR 705
            |      |:...|    |.|...|.......|.:..:.||..:||.||..|.|..|||     |.
Mouse   594 E------HTTFYHLKVQDVKEEQCFGYDAHHGTELPEMGLVVDGATCGPGKYCKAQRC-----VA 647

  Fly   706 QKGMGKPCP-EDCNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSGP 753
            ...:...|. ..||..|:||::|:|||..|:....|.:.|.|||.:|||
Mouse   648 HPTLNFNCNISSCNFRGVCNNKGNCHCVRGWQPPHCLQIGKGGSTNSGP 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	26/109 (24%)
		Reprolysin	269..464	CDD:279729	49/210 (23%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	49/208 (24%)
		Disintegrin	479..555	CDD:278623	30/75 (40%)
		ACR	558..701	CDD:214743	50/150 (33%)
Adam4	NP_033750.1	Pep_M12B_propep	60..163	CDD:279848	28/118 (24%)
		ZnMc_adamalysin_II_like	213..406	CDD:239797	55/269 (20%)
		Reprolysin	213..405	CDD:279729	54/268 (20%)
		DISIN	429..503	CDD:214490	30/76 (39%)
		ACR	505..648	CDD:214743	51/155 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920