DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and Adam22

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_006503591.1	Gene:	Adam22 / 11496	MGIID:	1340046	Length:	980	Species:	Mus musculus

Alignment Length:	973	Identity:	264/973 - (27%)
Similarity:	403/973 - (41%)	Gaps:	170/973 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 HTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTKTEVDLCHYQGHI 142
            |..:.|......|...|:|:..|..||.:.:..|  ....|   |.||   .....:.|:|||.|
Mouse    83 HVDKASFRVDAFGTSFVLDVLLNHELLSSGYVER--QIEHG---GKVV---ENKGGEHCYYQGQI 139

  Fly   143 RGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTNATCGYDNHR 207
            ||.|.|.||||||.| |.|:..||..||.|.|        :::....:.:..|....:..::...
Mouse   140 RGNPVSFVALSTCHG-LHGMFYDGNHTYLIEP--------EENEKSQESSHCHSVYKSRQFEFPL 195

  Fly   208 DDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRT------------LLRKRRQADDSSQLIRGP 260
            ||                 :||        ||.|.            |.|::|      ||:|.|
Mouse   196 DD-----------------LPS--------EFQRVNITPPQFILKPRLKRRKR------QLLRFP 229

  Fly   261 YNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYV-PLNIFVALVGVVIWNES 324
            .|..:.:.|:||:||.|:.::|..:.:....:.|.|.:.|:.:.:|. .|...:.||.:..|...
Mouse   230 RNVEEETKYIELMIVNDHLMFKKHRLSVVYTNTYAKSVVNMADVIYKDQLKTRIVLVAMETWAAD 294

  Fly   325 NEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSM 389
            |:...|.:..:|||.|:.||  :..:....|...|.:...|.....|.|..|.||:....|||:
Mouse   295 NKFAISENPLITLREFMKYR--RDFIKEKADAVHLFSGSQFESSRSGAAYIGGICSLLRGGGVN- 356

  Fly   390 QHSPNPAMVATTMAHEMGHNFGMEHD-----TSDCHCRD--EKCVMAASSTSFIPVNWSSCSIDQ 447
             ......::|.|:|..:.||.|:..|     :.:|.|.|  ..|:| ..:..::|..::.|::::
Mouse   357 -EFGKTDLMAVTLAQSLAHNVGIISDKRKLASGECKCEDTWSGCIM-GDTGYYLPKKFTQCNVEE 419

  Fly   448 LTIAFSRGMNYCLRNKPERLFESPTCGNGFVEPGEQCDCGLPEHC--ENA-CCNAQTCMLHSKNA 509
            .....:.|...||.|||.:|.:.|.|||||:|.||:||||.|..|  |.| ||  :.|.| ::::
Mouse   420 YHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECALEGAECC--KKCTL-TQDS 481

  Fly   510 TCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGT 574
            .|:.|.||  ..|:.:..|:.||||.|:||:.|.|:|.|..|..:|.:.|...|||.|..||.|.
Mouse   482 QCSDGLCC--KKCKFQPLGTVCREAVNDCDIREICSGNSSQCAPNVHKMDGYSCDGTQGICFGGR 544

  Fly   575 CRSHSNQCRTLWGPTGDNSE-HCYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLN 637
            |::...||:.:||.....|: :||.| |.|||..||||.::  .|:.:|.::.|.||.|.|.::.
Mouse   545 CKTRDRQCKYIWGQKVTASDRYCYEKLNIEGTEKGNCGKDK--DTWTQCNKRDVLCGYLLCTNIG 607

  Fly   638 ERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPVD 702
            .....|.....:.|...:...|.: .|..|.|.|. :..|.|...:|..||...||::.|||||.
Mouse   608 NIPRLGELDGEITSTLVVQQGRTL-NCSGAHVKLE-EDVDLGYVEDGTPCGPQMMCLEHRCLPVA 670

  Fly   703 AVRQKGMGKPCPED-----CNGNGICNSRGHCHCDVGFGGESC-SKAGSGGSPDSGPATDPNGSV 761
            :..    ...|...     |:|||:|::...|.|:..:.|..| :.........:|.....||..
Mouse   671 SFN----FSTCSSSKAGTVCSGNGVCSNELKCVCNRHWTGADCGTHFPHNDDAKTGITLSGNGVA 731

  Fly   762 GFKRFLYVLFFFVLPVVALFWFLYHCYKN----GMLTRGKLADNILKSSGGSK-----PITTRTN 817
            |....:.::...:|.:..:.......|||    ..|.:|   |.:.|...|..     |....||
Mouse   732 GTNIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQG---DYVKKPGDGDSFYSDFPPGGSTN 793

  Fly   818 QNGTGPPPSNGL-------LKSTPSSTDDMDSALLKSPSDSTPSAGLFGKFDGFTLRPLNDASSP 875
            ...:....||||       :..|...:|..::...:|.|......|...|..|...||.::::..
Mouse   794 SASSSKKRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNMGGNKKKIRGKRFRPRSNSTER 858

  Fly   876 ASNYNGPNVAFVQPTVQQDGPQRMAPPPPVVKPGTAPIHPPSPKPE------------------- 921
            ......|..:..| |:...|          :.||      .|..|:
Mouse   859 EPQAPEPGHSLAQ-TIPSQG----------ISPG------GSDSPQTGSLDHRYLNPWFKRDYNV 906

  Fly   922 ATWVRPAPALPPPNPGSTARPIIS----PPKLDSSTLTMVPLK---DSTEDLSPSRSAP-PVP 976
            |.||.....       :|..|..|    |.:.|.   |:.|.|   .||..::.||..| |:|
Mouse   907 AKWVEDVNK-------NTEGPYFSSQDGPHQQDR---TLSPAKSPSSSTGSIASSRKYPYPMP 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	36/95 (38%)
		Reprolysin	269..464	CDD:279729	52/202 (26%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	51/200 (26%)
		Disintegrin	479..555	CDD:278623	33/78 (42%)
		ACR	558..701	CDD:214743	49/144 (34%)
Adam22	XP_006503591.1	Pep_M12B_propep	48..186	CDD:366707	38/119 (32%)
		Reprolysin	237..436	CDD:366632	52/203 (26%)
		Disintegrin	451..524	CDD:365943	33/77 (43%)
		ACR	528..669	CDD:214743	49/144 (34%)
		EGF_2	677..709	CDD:285248	9/31 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.950