DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meltrin and Adam2

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_033748.2	Gene:	Adam2 / 11495	MGIID:	1340894	Length:	735	Species:	Mus musculus

Alignment Length:	798	Identity:	219/798 - (27%)
Similarity:	351/798 - (43%)	Gaps:	136/798 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 QSEGEKSKAHPVLEEFSTYTVIRPQVEHGRTKRSLLTTLDATDGLHTPQISLSYTHEGKRVVVDL 97
            |:||.:.|.|             .||......||:     .::|..| |::.:...|||...:||
Mouse    21 QTEGTREKLH-------------VQVTVPEKIRSV-----TSNGYET-QVTYNLKIEGKTYTLDL 66

  Fly    98 QRNDLLLPNSHFLRYQNASRGATPGHVVTTFTKTEVDLCHYQGHIRGKPESVVALSTCDGALDGI 162
            .:...|.||.....|.||.       ::.:..:...::|::||:|.|.|.|:|.:|||.| |.|.
Mouse    67 MQKPFLPPNFRVYSYDNAG-------IMRSLEQKFQNICYFQGYIEGYPNSMVIVSTCTG-LRGF 123

  Fly   163 VIDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGI 227
            :..|..:|.|                      .|..::.|::       |...:.:.:.|
Mouse   124 LQFGNVSYGI----------------------EPLESSSGFE-------HVIYQVEPEKG----- 154

  Fly   228 PSLPLRLDGGEFSRTLLRKRRQAD--DSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKK 290
                         ..||...:..|  ||...||........|.|:|:.|||:.:::::...:|..
Mouse   155 -------------GALLYAEKDIDLRDSQYKIRSIKPQRIVSHYLEIHIVVEKQMFEHIGADTAI 206

  Fly   291 VHQYCKGIANIINALYVPLNIFVALVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPND 355
            |.|....:..:.||::.|.|:.|.|..:..|.:.|:|..:.|.:..|..||.::.:.||| .|:|
Mouse   207 VTQKIFQLIGLANAIFAPFNLTVILSSLEFWMDENKILTTGDANKLLYRFLKWKQSYLVL-RPHD 270

  Fly   356 NAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPNPAMV-----ATTMAHEMGHNFGMEH- 414
            .|.||...| ....||...:|.:|...|:|||::    :|..|     |..:...:..:.|:.:
Mouse   271 MAFLLVYRN-TTDYVGATYQGKMCDKNYAGGVAL----HPKAVTLESLAIILVQLLSLSMGLAYD 330

  Fly   415 DTSDCHCRDEKCVMAASSTSFIPVN-WSSCSIDQLTIAFSRGMNYCLRNKPERL---FESPTCGN 475
            |.:.|.|....|||...:.....|. :|:||::..:...:...::||:|:| ||   ::...|||
Mouse   331 DVNKCQCGVPVCVMNPEAPHSSGVRAFSNCSMEDFSKFITSQSSHCLQNQP-RLQPSYKMAVCGN 394

  Fly   476 GFVEPGEQCDCGLPEHCEN---ACCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENE 537
            |.||..|.|||| .:.|..   .|||..||.| |..:.|::|.||:  :|:.|..|..||.|::|
Mouse   395 GEVEEDEICDCG-KKGCAEMPPPCCNPDTCKL-SDGSECSSGICCN--SCKLKRKGEVCRLAQDE 455

  Fly   538 CDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWG-PTGDNSEHCY-NKN 600
            ||:.|||.|.||.| .|.|.::..|||..:..|.:|||:|...||:.|:| ..|..|..|: ..|
Mouse   456 CDVTEYCNGTSEVC-EDFFVQNGHPCDNRKWICINGTCQSGEQQCQDLFGIDAGFGSSECFWELN 519

  Fly   601 TEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKIVACR 665
            ::....|:||.:.  ..:..|......||.:.|.:.:|.: ..:.||.|:..:...|     .|.
Mouse   520 SKSDISGSCGISA--GGYKECPPNDRMCGKIICKYQSENI-LKLRSATVIYANISGH-----VCV 576

  Fly   666 TALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPVDAVRQKGMGKPCP-EDCNGNGICNSRGHC 729
            :.....|...:......:|..||.:|:|.:|:|     |....:|..|. |.||.:|:||::.:|
Mouse   577 SLEYPQGHNESQKMWVRDGTVCGSNKVCQNQKC-----VADTFLGYDCNLEKCNHHGVCNNKKNC 636

  Fly   730 HCDVGFGGESCSK---AGSGGSPDSG--PATDP------------NGSVGFKRFLYVLFFFVLPV 777
            |||..:....|.:   :..|||.|||  ...:|            :.|..:..||.:.|:.|  :
Mouse   637 HCDPTYLPPDCKRMKDSYPGGSIDSGNKERAEPIPVRPYIASAYRSKSPRWPFFLIIPFYVV--I 699

  Fly   778 VALFWFLYHCYKNGMLTR 795
            :.|...|...|...|..|
Mouse   700 LVLIGMLVKVYSQRMKWR 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	33/109 (30%)
		Reprolysin	269..464	CDD:279729	55/201 (27%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	54/199 (27%)
		Disintegrin	479..555	CDD:278623	34/78 (44%)
		ACR	558..701	CDD:214743	37/144 (26%)
Adam2	NP_033748.2	Pep_M12B_propep	40..146	CDD:279848	36/148 (24%)
		Reprolysin	184..381	CDD:279729	55/202 (27%)
		ZnMc_adamalysin_II_like	185..379	CDD:239797	54/199 (27%)
		Disintegrin	398..469	CDD:278623	33/74 (45%)
		ACR	475..610	CDD:214743	37/147 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920