DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meltrin and Adam19

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_033746.1	Gene:	Adam19 / 11492	MGIID:	105377	Length:	920	Species:	Mus musculus

Alignment Length:	1136	Identity:	329/1136 - (28%)
Similarity:	472/1136 - (41%)	Gaps:	281/1136 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLNTCLQQH----ILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRTKRSLLTTLDA 73
            ||...||.|    ..:|...|     .|.:..:.|:..|     :|.||   .||..|      .
Mouse    12 LLALALQLHWPLAACEPGWTT-----RGSQEGSPPLQHE-----LIIPQ---WRTSES------P 57

  Fly    74 TDGLHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTKTEVDLCHY 138
            ..|.|..:..|....||:.:::||::|:.|...::......||     |:..|:..|:| |.|.|
Mouse    58 GRGKHPLRAELRVMAEGRELILDLEKNEHLFAPAYTETCYTAS-----GNPQTSTLKSE-DHCFY 116

  Fly   139 QGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIH--PHIDGRGRLQDDHYLLKQADMHPTNATC 201
            .|.:|...||.|.||||.|....|::....:|.|.  |:.|.:.|:    |..:...:.|.|  |
Mouse   117 HGTVRDVDESSVTLSTCRGIRGLIIVRSNLSYIIEPVPNSDSQHRI----YRSEHLTLPPGN--C 175

  Fly   202 GYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLR--KRRQADDSSQLIRGPYNAN 264
            |:: |....|.|:..                     :|:....:  :|.:.:|...:
Mouse   176 GFE-HSGPTSKDWAL---------------------QFTHQTKKQPRRMKREDLHSM-------- 210

  Fly   265 KYSSYVELVIVVDNKVYKNFQEN------TKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNE 323
               .||||.:|.|   |..||:|      ||:   ....|||.::..|..|||.:||||:.:|..
Mouse   211 ---KYVELYLVAD---YAEFQKNRHDQDATKR---KLMEIANYVDKFYRSLNIRIALVGLEVWTH 266

  Fly   324 SNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVS 388
            .::.|.|.:...||.:||::| .||:....:|||||:|..:|.|..:|.|....:|:...|||||
Mouse   267 GDKCEVSENPYSTLWSFLSWR-RKLLAQKSHDNAQLITGRSFQGTTIGLAPLMAMCSVYQSGGVS 330

  Fly   389 MQHSPNPAMVATTMAHEMGHNFGMEHDTSDC---HCRDEKCVMAASSTSFIPVNWSSCSIDQLTI 450
            |.||.|...||:|:|||:||||||.||::.|   ...|..|:|||::....|..:|.|:..:|..
Mouse   331 MDHSENAIGVASTVAHEIGHNFGMSHDSAHCCSASAADGGCIMAAATGHPFPKVFSWCNRKELDR 395

  Fly   451 AFSRGMNYCLRNKPE--RLFESPTCGNGFVEPGEQCDCGLPEHCENACCNAQTCMLHSKNATCAT 513
            ....|...||.|.|:  .|:....||||::|.||:||||..|.|:|.||||..|.| .:.|.||.
Mouse   396 YLQTGGGMCLSNMPDTRTLYGGRRCGNGYLEDGEECDCGEEEECKNPCCNASNCTL-KEGAECAH 459

  Fly   514 GECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSH 578
            |.||.  .|:....|:.|||...:|||||:|||:|.:||.:.::.|..||:||||||::|.|.::
Mouse   460 GSCCH--QCKLVAPGTQCREQVRQCDLPEFCTGKSPHCPTNYYQMDGTPCEGGQAYCYNGMCLTY 522

  Fly   579 SNQCRTLWGPTGDNS-EHCYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERLE 641
            ..||:.||||....: :.|:.: |..|...|||| ..||..:.:|..:...||.:.|.....|
Mouse   523 QEQCQQLWGPGARPALDLCFERVNAAGDTYGNCG-KGLNGQYRKCSPRDAKCGKIQCQSTQAR-- 584

  Fly   642 FGMESAAVLSHSYISHDRKIVACRTALVDLGLQ-------TTDPGLTPNGAKCGVDKMCVDQRCL 699
             .:||.||...:.|:.:.:.:.||...|..|.:       ..||||...|.|||.:.:|.:.:|.
Mouse   585 -PLESNAVSIDTTITLNGRRIHCRGTHVYRGPEEEEGEGDMLDPGLVMTGTKCGHNHICFEGQCR 648

  Fly   700 PVDAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSGPATDPNGSVGFK 764
            .......:|.||    .|||:|:||:..:|||..|:....|:..|.|||.||||.  |..|||
Mouse   649 NTSFFETEGCGK----KCNGHGVCNNNKNCHCFPGWSPPFCNTPGDGGSVDSGPL--PPKSVG-- 705

  Fly   765 RFLYVLFFFVLPVVALFWFLYHCYKNGMLTRGKLADNILKSSGGSKPITTRTNQNGTGPPPSNGL 829
             .:....|..|.|:|:...|.|||:                           ..:..|.|
Mouse   706 -PVIAGVFSALFVLAVLVLLCHCYR---------------------------QSHKLGKP----- 737

  Fly   830 LKSTPSSTDDMDSALLKSPSDSTPSAGLFGKFDGFTLR-----PLNDASSPASNYNGPNVAFVQP 889
                        |||                  .|.||     |...:.|..:.:..|......|
Mouse   738 ------------SAL------------------PFKLRHQFSCPFRVSQSGGTGHANPTFKLQTP 772

  Fly   890 TVQQDGPQRMAPPPPVVKPGTAPIHPPSPKPEATWVRPAPALPPPNPGSTARPIISPPKLDSSTL 954
                .|.:::...|..::   .|.||| |:|...::| ..:.|.|.|....|...|.|:..:
Mouse   773 ----QGKRKVTNTPESLR---KPSHPP-PRPPPDYLR-VESPPAPLPAHLNRAAGSSPEAGA--- 825

  Fly   955 TMVPLKDSTEDLSPSRSAPPVPLHADPKLNVKRDGTIRRFASFLKKEEKPPLKEKTYIDRERLRT 1019
             .:..|:|.....|||..||.|                                      ..|.:
Mouse   826 -RIERKESARRPPPSRPMPPAP--------------------------------------NCLLS 851

  Fly  1020 LEISAPMP----VPAAPQAESSNSDSETTPREEETQNLVKRAQSMRSPTKKAPLQSFGSMRSPPG 1080
            .:.|.|.|    :||.|.     ....|.||...|                       |:..||
Mouse   852 QDFSRPRPPQKALPANPV-----PGQRTGPRSGGT-----------------------SLLQPP- 887

  Fly  1081 LPRPKSGQVNSNGASRPKSPPPRPPPVVVKK 1111
                         .|.|:  |||||.|.|.|
Mouse   888 -------------TSGPQ--PPRPPAVPVPK 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	32/111 (29%)
		Reprolysin	269..464	CDD:279729	81/203 (40%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	80/201 (40%)
		Disintegrin	479..555	CDD:278623	38/75 (51%)
		ACR	558..701	CDD:214743	50/151 (33%)
Adam19	NP_033746.1	Pep_M12B_propep	55..162	CDD:279848	34/118 (29%)
		Cysteine switch. /evidence=ECO:0000250	131..138		4/6 (67%)
		Reprolysin	211..409	CDD:279729	81/204 (40%)
		ZnMc_adamalysin_II_like	211..407	CDD:239797	80/202 (40%)
		DISIN	440..500	CDD:214490	29/62 (47%)
		ACR	502..650	CDD:214743	50/151 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	755..920		50/244 (20%)
		SH3-binding. /evidence=ECO:0000255	835..846		5/10 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4215
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74925
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1692
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0000154
OrthoInspector	1	1.000	-	-		otm43605
orthoMCL	1	0.900	-	-		OOG6_101958
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.870