Protein Alignment Meltrin and Adam17

DIOPT Version :9

• Sequence 1: NP_001027575.1
• Gene: Meltrin / 3772109
• FlyBaseID: FBgn0265140
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: NP_001264195.1
• Gene: Adam17 / 11491
• MGIID: 1096335
• Length: 846
• Species: Mus musculus
• Alignment Length: 1157
• Identity: 236/1157 - (20%)
• Similarity: 358/1157 - (30%)
• Gaps: 433/1157 - (37%)

  Fly    12 LLLNTCLQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRTKRSLLTTLDATDG 76
            ||:.|.|...:|.|      ...|...|.:||.||:..                |||:..|....
Mouse     5 LLILTTLVPFVLAP------RPPEEAGSGSHPRLEKLD----------------SLLSDYDILSL 47

  Fly    77 LHTPQISLSYTHEGKRVVVDLQRNDLLLPNS----HFLRYQNAS--RGATPGHVVTTFTKTEVDL 135
            .:..|.|:.     ||.:......:.||..|    ||..|..:|  |.:....||....|.|.:.
Mouse    48 ANIQQHSIR-----KRDLQSATHLETLLTFSALKRHFKLYLTSSTERFSQNLRVVVVDGKEESEY 107

  Fly   136 C-----HYQGHIRGKPESVVALSTCDGALDGIVI----DGRQTYFIHPHIDGRGRLQDDHYLL-K 190
            .     .:.||:.|:|:|.|.....|   |.:.:    ||.: |.:.|........:|...|: |
Mouse   108 SVKWQNFFSGHVVGEPDSRVLAHIGD---DDVTVRINTDGAE-YNVEPLWRFVNDTKDKRMLVYK 168

  Fly   191 QADMH-----PTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQA 250
            ..|:.     .:...|||.|           ||.:..|..|:..   |....||.|   |.:|:|
Mouse   169 SEDIKDFSRLQSPKVCGYLN-----------ADSEELLPKGLID---REPSEEFVR---RVKRRA 216

  Fly   251 DDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNF----QENTKKVHQYCKGIANIINALYVPLNI 311
            :           .|...:..:|::|.|::.||..    :..|.....|..|..:.:..... |..
Mouse   217 E-----------PNPLKNTCKLLVVADHRFYKYMGRGEESTTTNYLGYISGTRDRVTTDCF-LEF 269

  Fly   312 FVALVGVV-------IWNES-----------------------------------NEIEFSSDGD 334
            .:.|:..|       .|:.:                                   ||.:.:.|..
Mouse   270 LIELIDRVDDIYRNTSWDNAGFKGYGVQIEQIRILKSPQEVKPGERHFNMAKSFPNEEKDAWDVK 334

  Fly   335 LTLRNF---LNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPNP- 395
            :.|..|   :...::|:.|.|      |.|.::|..|.:|.|..|......: |||..:...||
Mouse   335 MLLEQFSFDIAEEASKVCLAH------LFTYQDFDMGTLGLAYVGSPRANSH-GGVCPKAYYNPT 392

  Fly   396 -------------------------AMVATTMAHEMGHNFGMEHD---TSDCHCRDE---KCVMA 429
                                     |.:.||  ||:|||||.|||   .::|...::   |.||.
Mouse   393 VKKNIYLNSGLTSTKNYGKTILTKEADLVTT--HELGHNFGAEHDPDGLAECAPNEDQGGKYVMY 455

  Fly   430 ASSTSFIPVN---WSSCSIDQLTIAFSRGMNYCLRNKPERLFESPTCGNGFVEPGEQCDCGLPEH 491
            ..:.|....|   :|:||...:..........|.:.:..::     |||..|:.||:||.|:...
Mouse   456 PIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKV-----CGNSRVDEGEECDPGIMYL 515

  Fly   492 CENACCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAEN-ECDLPEYCTGESEYCPADV 555
            ..:.|||:...:......:.....||  ..|:.:.|...|:||.| .|....||||.|..||
Mouse   516 NNDTCCNSDCTLKPGVQCSDRNSPCC--KNCQFETAQKKCQEAINATCKGVSYCTGNSSECP--- 575

  Fly   556 FRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWGPTGDNSEHCYNKNTEGTRLGNCGYNRLNKTFLR 620
                                            |.||..:     :|....||.|...:
Mouse   576 --------------------------------PPGDAED-----DTVCLDLGKCKAGK------- 596

  Fly   621 CEEQHVNCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPGLTPNGA 685
                        ||                  .:...::::.:|  |.||          |.|..
Mouse   597 ------------CI------------------PFCKREQELESC--ACVD----------TDNSC 619

  Fly   686 KCGVDKMC---VDQRCLPVDAVRQKGM----GKPCPEDCNGNGICNSRGHCHCDVGFGGESCSKA 743
                 |:|   :...|:|.....||.:    ||||..     |.|:..|.|.
Mouse   620 -----KVCCRNLSGPCVPYVDAEQKNLFLRKGKPCTV-----GFCDMNGKCE------------- 661

  Fly   744 GSGGSPDSGPATDPNGSVGFKRFLYVLFFFVLPVVALFW-FLYHCYKNGMLTRGK-LADNILKSS 806
                                ||        |..|:..|| |:.....|   |.|| |||||:
Mouse   662 --------------------KR--------VQDVIERFWDFIDQLSIN---TFGKFLADNIV--- 692

  Fly   807 GGSKPITTRTNQNGTGPPPSNGLLKSTPSS--TDDMDSALLKSPSDSTPSAGLFGKFDGFTLRPL 869
             ||..:.:              |:...|.|  ...:|..|.|    ...|..||...:...|..:
Mouse   693 -GSVLVFS--------------LIFWIPFSILVHCVDKKLDK----QYESLSLFHHSNIEMLSSM 738

  Fly   870 NDASSPASNYNGPNVAFVQPTVQQDGPQRMAPPPPVVKPGTAPIHPPSPKPEATWVRPAPALPPP 934
            :.||                             ..::||..||..|...:.    ::||..:|
Mouse   739 DSAS-----------------------------VRIIKPFPAPQTPGRLQA----LQPAAMMP-- 768

  Fly   935 NPGSTARPIISPPKLDSSTLTMVPLKDSTEDLSPSRSAPPVPLHADPKLNVKRDGTIRRFASFLK 999
                   |:.:.||||...:..:....||:.            |||.      ||.
Mouse   769 -------PVPAAPKLDHQRMDTIQEDPSTDS------------HADD------DGF--------- 799

  Fly  1000 KEEKPPLKEKTYIDRERLRTLEISAPMPVPAAPQAESSNSDSETTPREEETQ 1051
              ||.|....:    ...::.|.....||..:.:|.|.....::....:||:
Mouse   800 --EKDPFPNSS----TAAKSFEDLTDHPVTRSEKAASFKLQRQSRVDSKETE 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	31/124 (25%)
		Reprolysin	269..464	CDD:279729	55/278 (20%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	55/276 (20%)
		Disintegrin	479..555	CDD:278623	24/76 (32%)
		ACR	558..701	CDD:214743	18/145 (12%)
Adam17	NP_001264195.1	Pep_M12B_propep	49..167	CDD:366707	30/126 (24%)
		ZnMc_TACE_like	223..496	CDD:239798	55/282 (20%)
		DISIN	503..578	CDD:214490	25/111 (23%)
		ADAM17_MPD	600..660	CDD:374734	19/81 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950